Design, Synthesis, DNA Binding, and Docking Studies of Thiazoles and Thiazole-Containing Triazoles as Antibacterials

Rangappa Santosh, KS Mukunthan, Saptami U. Kanekar, Gundibasappa K. Nagaraja, Madan Kumar

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A series of thiazoles 4 a-g and thiazole clubbed triazoles 5 a-f were synthesized and showed good antibacterial activity against, Pseudomonas aeruginosa, Escherchia coli, Staphylococcus aureus and Bacillus subtilis. Particularly, 4 a (methyl), 5 b (nitro) and 5 d (fluoro) derivatives demonstrated a broad range of activity over other derivatized compounds. In addition, Computational interaction, ADMET (absorption, distribution, metabolism, and excretion - toxicity in pharmacokinetics), Lipinski's rule and DNA binding studies of all the results stacked together indicated that 5 b can be further developed as lead molecule against bacterial pathogens.

Original languageEnglish
Pages (from-to)3892-3898
Number of pages7
JournalChemistrySelect
Volume3
Issue number14
DOIs
Publication statusPublished - 17-04-2018

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Thiazoles
Triazoles
Pharmacokinetics
DNA
Pathogens
Bacilli
Metabolism
Toxicity
Derivatives
Molecules

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Santosh, Rangappa ; Mukunthan, KS ; Kanekar, Saptami U. ; Nagaraja, Gundibasappa K. ; Kumar, Madan. / Design, Synthesis, DNA Binding, and Docking Studies of Thiazoles and Thiazole-Containing Triazoles as Antibacterials. In: ChemistrySelect. 2018 ; Vol. 3, No. 14. pp. 3892-3898.
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Design, Synthesis, DNA Binding, and Docking Studies of Thiazoles and Thiazole-Containing Triazoles as Antibacterials. / Santosh, Rangappa; Mukunthan, KS; Kanekar, Saptami U.; Nagaraja, Gundibasappa K.; Kumar, Madan.

In: ChemistrySelect, Vol. 3, No. 14, 17.04.2018, p. 3892-3898.

Research output: Contribution to journalArticle

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