@article{ebeaa3b5a6e84c21a2a47cb6d2e4898e,
title = "Determination of ebastine in pharmaceutical formulations by HPLC",
abstract = "A simple, precise and rapid RP-HPLC method was developed for the determination of ebastine in pharmaceutical formulations. The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (90:10) and detection was done at 262 nm. The linearity range was 5-100 μg/ml. The intra-day and inter-day precision were in the range of 0.22% to 0.49% and 0.24% to 0.73%, respectively.",
author = "S. Prabu and C. Kumar and A. Shirwaikar",
note = "Cited By :13 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India; email: arunshirwaikar@yahoo.co.in Chemicals/CAS: ebastine, 90729-43-4; methanol, 67-56-1; water, 7732-18-5 Manufacturers: Eros, India References: Llupia, J., Gras, J., Llenas, J., Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical models (2003) Arzneimittel Forschung, 53, pp. 93-97; Weiner, M., Sedation and antihistaminics (1982) Arzneimittel Forschung, 32, pp. 1193-1195; Simons, F.E., Simons, K.J., Clinical pharmacology of new histamine H1 receptor antagonists (1999) Clin Pharmacokinet, 36 (5), pp. 329-352; Kang, W., Liu, K.H., Ryu, J.Y., Simultaneous determination of ebastine and its three metabolites in plasma using liquid chromatography-tandem mass spectrometry (2004) J Chromatogr B, 813 (1-2), pp. 75-80; Rohatagi, S., Gillen, M., Aubeneau, M., Jan, C., Pandit, B., Jensen, B.K., Effect of age and gender on the pharmacokinetics of ebastine after single and repeated dosing in healthy subjects (2001) Int J Clin Pharmacol Theor, 39 (3), pp. 126-134",
year = "2008",
doi = "10.4103/0250-474X.43022",
language = "English",
volume = "70",
pages = "406--407",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "3",
}