Development and characterization of irbesartan co-crystals

Akhil Nair, R. Harini, P. Melissa, Krupali Shah, Usha Y. Nayak, R. Mahalaxmi, T. Vamshi Krishna

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the work was to prepare co-crystals of irbesartan (IBS), a BCS Class II drug to enhance its aqueous solubility and bioavailability. The solvent evaporation method was used to prepare co-crystals by using different co-formers and varying the drug to co-former molar ratios. Succinic acid and benzoic acid co-crystals were formed with good physicochemical properties. The solid-state characterization of co-crystals was studied by FTIR, DSC, and XRD. The co-crystals were evaluated for the saturation solubility and dissolution studies. There was a 2-fold increase in the aqueous solubility and 4-8 fold increase in dissolution rate of co-crystals. Solid state characterizations indicated there was no change in the chemical nature of the co-crystals compared to pure drug. Presence of crystalline co-former induced crystallinity to the developed co-crystals. Thus, developed co-crystals were found to be a suitable alternative to increase the solubility and dissolution rate of IBS.

Original languageEnglish
Pages (from-to)3932-3936
Number of pages5
JournalResearch Journal of Pharmacy and Technology
Volume11
Issue number9
DOIs
Publication statusPublished - 09-2018

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)

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