Development and evaluation of transdermal formulations containing metronidazole and norfloxacin for the treatment of bum wound

S. Pandey, M. Basheer, S. Roy, N. Udupa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In an attempt for better treatment of partial thickness bum wounds topical ointments containing metronidazole and norfloxacin in different bases were prepared and in vitro release was conducted in phosphate buffer pH 6. It was found that, diffusion of the metronidazole and norfloxacin from the lanolin petrolatum base with 0.25% w/w dimethyl sulfoxide was maximum through hairless rat abdominal skin. Antimicrobial activity of different prepared formulations was found to be more effective both against aerobic and anaerobic bacteria than marketed formulation (1% silver sulfadiazine cream USP). Formulations were significantly effective as compared to that of marketed formulation in wound contraction of the partial thickness bum wound. Histopathological reports supported effectiveness of formulations. It was found that 1% metronidazole and 1% norfloxacin ointments are suitable for treating the partial thickness bum wound.

Original languageEnglish
Pages (from-to)450-454
Number of pages5
JournalIndian Journal of Experimental Biology
Volume37
Issue number5
Publication statusPublished - 1999

Fingerprint

Norfloxacin
Metronidazole
Wounds and Injuries
Ointments
Lanolin
Hairless Rats
Silver Sulfadiazine
Petrolatum
Aerobic Bacteria
Anaerobic Bacteria
Dimethyl Sulfoxide
Buffers
Phosphates
Skin

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine(all)
  • Molecular Biology
  • Cell Biology

Cite this

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abstract = "In an attempt for better treatment of partial thickness bum wounds topical ointments containing metronidazole and norfloxacin in different bases were prepared and in vitro release was conducted in phosphate buffer pH 6. It was found that, diffusion of the metronidazole and norfloxacin from the lanolin petrolatum base with 0.25{\%} w/w dimethyl sulfoxide was maximum through hairless rat abdominal skin. Antimicrobial activity of different prepared formulations was found to be more effective both against aerobic and anaerobic bacteria than marketed formulation (1{\%} silver sulfadiazine cream USP). Formulations were significantly effective as compared to that of marketed formulation in wound contraction of the partial thickness bum wound. Histopathological reports supported effectiveness of formulations. It was found that 1{\%} metronidazole and 1{\%} norfloxacin ointments are suitable for treating the partial thickness bum wound.",
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Development and evaluation of transdermal formulations containing metronidazole and norfloxacin for the treatment of bum wound. / Pandey, S.; Basheer, M.; Roy, S.; Udupa, N.

In: Indian Journal of Experimental Biology, Vol. 37, No. 5, 1999, p. 450-454.

Research output: Contribution to journalArticle

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