Development and validation of a UV spectroscopic method to estimate etoricoxib in bulk and tablet formulation

Garlapati Manideep, Nazare Lobo John Shane, Girish Pai, Muddukrishna Badamane Sathyanarayana

Research output: Contribution to journalArticle

Abstract

This present UV Spectrophotometric method developed using methanol as a solvent is simple, rapid, specific, precise and sensitive to estimation Etoricoxib in bulk in day to day analysis. The method was validated as per ICH Q2R1 guideline. Etoricoxib is the newest addition to the group of Non-Steroidal Anti-Inflammatory Drugs-highly selective COX-2 inhibitor. The solvent used in the entire method development and validation was methanol. The maximum wavelength of absorption was found to be 234nm. Beer’s law was obeyed in the concentration range of 1 to 11µg/mL with correlation coefficient of 0.9986. The method was precise with an RSD of0.42%the LOD and LOQ were found to be 0.09µg/ml and 0.2µg/ml respectively. The method was validated for precision, linearity, accuracy and robustness and all parameters were found to be satisfactory which proves that this method can be used for routine analysis of Etoricoxib.

Original languageEnglish
Pages (from-to)758-760
Number of pages3
JournalResearch Journal of Pharmacy and Technology
Volume11
Issue number2
DOIs
Publication statusPublished - 01-02-2018

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)

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