Development and validation of diclofenac sodium in tablets using simple UV spectrophotometric method

Ragini V. Mane, Kritika Patel, Gude Sai Sushmitha, S. G. Vasantharaju

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

An effective and simple UV-Spectrophotometric method was developed and validated for the quantification of Diclofenac sodium in tablets. The maximum absorption was found to be 282nm by using methanol as the solvent. The linearity range was 6-21 µg/ml and the correlation coefficient (r2) was found to be 0.9985. The method was accurate, precise, and robust with %RSD below 2%. The LOD and LOQ was found to be 0.0885µg/Ml and 0.250µg/mL respectively. Sandel’s sensitivity was found to be 0.000002 µg/mL. Assay and accuracy of the tablets were about of the acceptance criteria range as per the ICH guidelines.

Original languageEnglish
Pages (from-to)611-614
Number of pages4
JournalResearch Journal of Pharmacy and Technology
Volume12
Issue number2
DOIs
Publication statusPublished - 01-02-2019

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)

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