Development and validation of RP-HPLC method for the estimation of granisetron hydrochloride in bulk and tablets

S. Lakshmana Prabu, C. Dinesh Kumar, N. Sivagurunathan, S.G. Vasantharaju, A. Jacob

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A simple, precise and rapid RP-HPLC method was developed for the determination of Granisetron hydrochloride in pharmaceutical formulation. The method was carried out on a phenomenex RP-C18 column using a mixture of methanol and water (75:25). Detection was done at 301nm. The linearity range was 5 - 100.0mcg/mL. The proposed method was statistically validated and successfully applied for analysis of tablet dosage forms. The percentage recovery was found to be between the ranges of 98.81% to 99.30%.
Original languageEnglish
Pages (from-to)66-69
Number of pages4
JournalIndian Drugs
Volume47
Issue number1
Publication statusPublished - 2010

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