A simple, precise and rapid RP-HPLC method was developed for the determination of Granisetron hydrochloride in pharmaceutical formulation. The method was carried out on a phenomenex RP-C18 column using a mixture of methanol and water (75:25). Detection was done at 301nm. The linearity range was 5 - 100.0mcg/mL. The proposed method was statistically validated and successfully applied for analysis of tablet dosage forms. The percentage recovery was found to be between the ranges of 98.81% to 99.30%.
|Number of pages||4|
|Publication status||Published - 2010|
Lakshmana Prabu, S., Dinesh Kumar, C., Sivagurunathan, N., Vasantharaju, S. G., & Jacob, A. (2010). Development and validation of RP-HPLC method for the estimation of granisetron hydrochloride in bulk and tablets. Indian Drugs, 47(1), 66-69.