@article{e666f639191046419ae7c716ee03877f,
title = "Development and validation of RP-HPLC method for the estimation of granisetron hydrochloride in bulk and tablets",
abstract = "A simple, precise and rapid RP-HPLC method was developed for the determination of Granisetron hydrochloride in pharmaceutical formulation. The method was carried out on a phenomenex RP-C18 column using a mixture of methanol and water (75:25). Detection was done at 301nm. The linearity range was 5 - 100.0mcg/mL. The proposed method was statistically validated and successfully applied for analysis of tablet dosage forms. The percentage recovery was found to be between the ranges of 98.81% to 99.30%.",
author = "{Lakshmana Prabu}, S. and {Dinesh Kumar}, C. and N. Sivagurunathan and S.G. Vasantharaju and A. Jacob",
note = "Cited By :2 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Dinesh Kumar, C.; Manipal College of Pharmaceutical Sciences, Manipal - 576 104, Karnataka, India; email: c_dinesh78@yahoo.co.in Chemicals/CAS: granisetron, 107007-99-8, 109889-09-0; methanol, 67-56-1; water, 7732-18-5 References: Jiang, Y., Lin, M., Fan, G., Chen, Y., Li, Z., Zhao, W., Wu, Y., Hu, J., Rapid determination of granisetron in human plasma by liquid chromatography coupled to tandem mass spectrometry and its application to bioequivalence study (2006) Journal of Pharmaceutical and Biomedical Analysis, 42 (4), pp. 464-473. , DOI 10.1016/j.jpba.2006.05.001, PII S0731708506003608; Boppana, V.K., Simultaneous determination of granisetron and its 7-hydroxy metabolite in human plasma by reverse phase high performance liquid chromatography utilizing fluorescence and electrochemical detection (1995) J Chromatogr. A, 692, pp. 195-202; Huang, C.T., Chen, C.F., Chen, K.C., Tsai, T.H., Simultaneous measurement of blood and brain microdialysates of granisetron in rat by high performance liquid chromatography with fluorescence detection (1998) J Chromatogr. B, 716, pp. 251-255; Wada, I., Satoh, M., Takeda, T., Nakabayashi, T., Honma, T., Saitoh, H., Takada, M., Hirano, K., A rapid assay of granisetron in biological fluids from cancer patients (1998) Biological and Pharmaceutical Bulletin, 21 (5), pp. 535-537; McElvain, J.S., Vandiver, V.J., Eichemeir, L.S., Validation of a reverse phase HPLC method for directly quantifying the enantiomers of MDL 74,156, the primary metabolite of dolasetron mesylate in human plasma (1997) J Pharm. Biomed. Anal., 15, pp. 513-521; Pinguet, F., Bressolle, F., Martel, P., Salabert, D., Astre, C., High-performance liquid chromatographic determination of granisetron in human plasma (1996) Journal of Chromatography B: Biomedical Applications, 675 (1), pp. 99-105. , DOI 10.1016/0378-4347(95)00335-5; Cupissol, D., Bressolle, F., Adenis, L., Carmichael, J., Bessell, E., Allen, A., Wargenau, M., Romain, D., Evaluation of the bioequivalence of tablet and capsule formulations of granisetron in patients undergoing cytotoxic chemotherapy for malignant disease (1993) Journal of Pharmaceutical Sciences, 82 (12), pp. 1281-1284. , DOI 10.1002/jps.2600821221; Capacio, B.R., Byers, C.E., Jackson, T.K., Matthews, R.L., An HPLC method for the determination of granisetron in guinea pig plasma (1993) Journal of Analytical Toxicology, 17 (3), pp. 151-155; Nirogi, R.V.S., Kandikere, V.N., Shukla, M., Mudigonda, K., Maurya, S., Boosi, R., Quantification of granisetron in human plasma by liquid chromatography coupled to electrospray tanden mass spectrometry (2006) Biomed. Chromatogr., 21, pp. 241-248",
year = "2010",
language = "English",
volume = "47",
pages = "66--69",
journal = "Indian Drugs",
issn = "0019-462X",
publisher = "Indian Drug Manufacturers' Association",
number = "1",
}