Development and validation of RP-HPLC method for the estimation of etoricoxib in bulk and tablets

S. Lakshmana Prabu, S. Annie, C. Dinesh Kumar, A. Shirwaikar, A. Kumar

Research output: Contribution to journalArticle

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Abstract

A simple, precise and rapid RP-HPLC method was developed for the determination of etoricoxib in pharmaceutical dosage forms. The quantification was carried out using a Phenomenex RP-C18 column in isocratic mode, with mobile phase consisting of methanol and water (70:30). The mobile phase was pumped at a flow rate 1.0 mL/min and the detection was carried out at 238nm and the linearity was found to be 10-50 mcg/mL. The LOD and LOQ were found to be 200 ng/ml and 600 ng/ml respectively. The proposed method was found to be simple, precise, accurate, rapid and reproducible for the estimation of etoricoxib in bulk drug and tablets. The intra-day and inter-day precision were in the range of 0.50 to 0.71 and 0.42 to 0.93 respectively.
Original languageEnglish
Pages (from-to)56-58
Number of pages3
JournalIndian Drugs
Volume46
Issue number9
DOIs
Publication statusPublished - 2009

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etoricoxib
Tablets
High Pressure Liquid Chromatography
Dosage Forms
Pharmaceutical Preparations
Methanol
Water

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Lakshmana Prabu, S., Annie, S., Dinesh Kumar, C., Shirwaikar, A., & Kumar, A. (2009). Development and validation of RP-HPLC method for the estimation of etoricoxib in bulk and tablets. Indian Drugs, 46(9), 56-58. https://doi.org/10.1016/S0731-7085(03)00293-0
Lakshmana Prabu, S. ; Annie, S. ; Dinesh Kumar, C. ; Shirwaikar, A. ; Kumar, A. / Development and validation of RP-HPLC method for the estimation of etoricoxib in bulk and tablets. In: Indian Drugs. 2009 ; Vol. 46, No. 9. pp. 56-58.
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abstract = "A simple, precise and rapid RP-HPLC method was developed for the determination of etoricoxib in pharmaceutical dosage forms. The quantification was carried out using a Phenomenex RP-C18 column in isocratic mode, with mobile phase consisting of methanol and water (70:30). The mobile phase was pumped at a flow rate 1.0 mL/min and the detection was carried out at 238nm and the linearity was found to be 10-50 mcg/mL. The LOD and LOQ were found to be 200 ng/ml and 600 ng/ml respectively. The proposed method was found to be simple, precise, accurate, rapid and reproducible for the estimation of etoricoxib in bulk drug and tablets. The intra-day and inter-day precision were in the range of 0.50 to 0.71 and 0.42 to 0.93 respectively.",
author = "{Lakshmana Prabu}, S. and S. Annie and {Dinesh Kumar}, C. and A. Shirwaikar and A. Kumar",
note = "Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Shirwaikar, A.; Dept. of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, Karnataka, India; email: arunshirwaikar@yahoo.co.in Chemicals/CAS: etoricoxib, 202409-33-4, 202409-40-3 Manufacturers: nimish pharmaceuticals, India References: Cochrane, D.J., Jarvis, B., Keating, G.M., Etoricoxib (2002) Drugs, 62 (18), p. 2637; D Martina, S., Vesta, K.S., Ripley, T.L., Etoricoxib: A highly selective COX-2 inhibitor (2005) Annals of Pharmacotherapy, 39 (5), pp. 854-862. , DOI 10.1345/aph.1E543; Chang, D.J., Desjardins, P.J., King, T.R., Erb, T., Geba, G.P., The analgesic efficacy of etoricoxib compared with oxycodone/ acetaminophen in an acute postoperative pain model: A randomized, double-blind clinical trial (2004) Anesthesia and Analgesia, 99 (3), pp. 807-815. , DOI 10.1213/01.ANE.0000133141.75831.57; Agrawal, N.G., Matthews, C.Z., Mazenko, R.S., Cline, W.F., Woolf, W.J., Porras, A.G., Pharmacokinetics of etoricoxib in patients with renal impairment (2004) J. Clin. Pharmacol., 44 (1), p. 48; Werner, U., Wemer, D., Hinz, B., Lambrecht, C., Brune, K., A liquid chromatography-mass spectrometry method for the quantification of both etoricoxib and valdecoxib in human plasma (2005) Biomed. Chromatogr., 19 (2), p. 113; Brautigam, L., Nefflen, Geisshinger, G., Determination of etoricoxib in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionistion (2003) J. Chromatography B, 788 (2), p. 309; Brum Jr., L., Fronza, M., Ceni, D.C., Barth, T., Dalmora, S.L., Validation of liquid chromatography and liquid chromatography/tandem mass spectrometry methods for the determination of etoricoxib in pharmaceutical formulations (2006) Journal of AOAC International, 89 (5), pp. 1268-1275; Matthews, C.Z., Subramanian, R., Woolf, E.J., Foster, N., Matuszewski, B.K., Isolation and structural characterization of the photolysis products of etoricoxib (2004) Pharmazie, 59 (12), pp. 913-919; Ramakrishna, N.V.S., Viswottam, K.N., Wishu, S., Koteshwara, M., Validated liquid chromatographic ultraviolet method for the quantitation of etoricoxib in human plasma using liquid-liquid extraction (2005) J. Chromatography B Analyt Technol Biomed Life Sci., 816 (1-2), p. 215; Suhagia, B.N., Patel, H.M., Shah, S.A., Rathod, I.S., Marolia, B.P., (2005) Ind. J. Pharm. Sci., 5, p. 634; Nageswara Rao, R., Nagaraju, V., An overview of the recent trends in development of HPLC methods for determination of impurities in drugs (2003) Journal of Pharmaceutical and Biomedical Analysis, 33 (3), pp. 335-377. , DOI 10.1016/S0731-7085(03)00293-0",
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Lakshmana Prabu, S, Annie, S, Dinesh Kumar, C, Shirwaikar, A & Kumar, A 2009, 'Development and validation of RP-HPLC method for the estimation of etoricoxib in bulk and tablets', Indian Drugs, vol. 46, no. 9, pp. 56-58. https://doi.org/10.1016/S0731-7085(03)00293-0

Development and validation of RP-HPLC method for the estimation of etoricoxib in bulk and tablets. / Lakshmana Prabu, S.; Annie, S.; Dinesh Kumar, C.; Shirwaikar, A.; Kumar, A.

In: Indian Drugs, Vol. 46, No. 9, 2009, p. 56-58.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Development and validation of RP-HPLC method for the estimation of etoricoxib in bulk and tablets

AU - Lakshmana Prabu, S.

AU - Annie, S.

AU - Dinesh Kumar, C.

AU - Shirwaikar, A.

AU - Kumar, A.

N1 - Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Shirwaikar, A.; Dept. of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, Karnataka, India; email: arunshirwaikar@yahoo.co.in Chemicals/CAS: etoricoxib, 202409-33-4, 202409-40-3 Manufacturers: nimish pharmaceuticals, India References: Cochrane, D.J., Jarvis, B., Keating, G.M., Etoricoxib (2002) Drugs, 62 (18), p. 2637; D Martina, S., Vesta, K.S., Ripley, T.L., Etoricoxib: A highly selective COX-2 inhibitor (2005) Annals of Pharmacotherapy, 39 (5), pp. 854-862. , DOI 10.1345/aph.1E543; Chang, D.J., Desjardins, P.J., King, T.R., Erb, T., Geba, G.P., The analgesic efficacy of etoricoxib compared with oxycodone/ acetaminophen in an acute postoperative pain model: A randomized, double-blind clinical trial (2004) Anesthesia and Analgesia, 99 (3), pp. 807-815. , DOI 10.1213/01.ANE.0000133141.75831.57; Agrawal, N.G., Matthews, C.Z., Mazenko, R.S., Cline, W.F., Woolf, W.J., Porras, A.G., Pharmacokinetics of etoricoxib in patients with renal impairment (2004) J. Clin. Pharmacol., 44 (1), p. 48; Werner, U., Wemer, D., Hinz, B., Lambrecht, C., Brune, K., A liquid chromatography-mass spectrometry method for the quantification of both etoricoxib and valdecoxib in human plasma (2005) Biomed. Chromatogr., 19 (2), p. 113; Brautigam, L., Nefflen, Geisshinger, G., Determination of etoricoxib in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionistion (2003) J. Chromatography B, 788 (2), p. 309; Brum Jr., L., Fronza, M., Ceni, D.C., Barth, T., Dalmora, S.L., Validation of liquid chromatography and liquid chromatography/tandem mass spectrometry methods for the determination of etoricoxib in pharmaceutical formulations (2006) Journal of AOAC International, 89 (5), pp. 1268-1275; Matthews, C.Z., Subramanian, R., Woolf, E.J., Foster, N., Matuszewski, B.K., Isolation and structural characterization of the photolysis products of etoricoxib (2004) Pharmazie, 59 (12), pp. 913-919; Ramakrishna, N.V.S., Viswottam, K.N., Wishu, S., Koteshwara, M., Validated liquid chromatographic ultraviolet method for the quantitation of etoricoxib in human plasma using liquid-liquid extraction (2005) J. Chromatography B Analyt Technol Biomed Life Sci., 816 (1-2), p. 215; Suhagia, B.N., Patel, H.M., Shah, S.A., Rathod, I.S., Marolia, B.P., (2005) Ind. J. Pharm. Sci., 5, p. 634; Nageswara Rao, R., Nagaraju, V., An overview of the recent trends in development of HPLC methods for determination of impurities in drugs (2003) Journal of Pharmaceutical and Biomedical Analysis, 33 (3), pp. 335-377. , DOI 10.1016/S0731-7085(03)00293-0

PY - 2009

Y1 - 2009

N2 - A simple, precise and rapid RP-HPLC method was developed for the determination of etoricoxib in pharmaceutical dosage forms. The quantification was carried out using a Phenomenex RP-C18 column in isocratic mode, with mobile phase consisting of methanol and water (70:30). The mobile phase was pumped at a flow rate 1.0 mL/min and the detection was carried out at 238nm and the linearity was found to be 10-50 mcg/mL. The LOD and LOQ were found to be 200 ng/ml and 600 ng/ml respectively. The proposed method was found to be simple, precise, accurate, rapid and reproducible for the estimation of etoricoxib in bulk drug and tablets. The intra-day and inter-day precision were in the range of 0.50 to 0.71 and 0.42 to 0.93 respectively.

AB - A simple, precise and rapid RP-HPLC method was developed for the determination of etoricoxib in pharmaceutical dosage forms. The quantification was carried out using a Phenomenex RP-C18 column in isocratic mode, with mobile phase consisting of methanol and water (70:30). The mobile phase was pumped at a flow rate 1.0 mL/min and the detection was carried out at 238nm and the linearity was found to be 10-50 mcg/mL. The LOD and LOQ were found to be 200 ng/ml and 600 ng/ml respectively. The proposed method was found to be simple, precise, accurate, rapid and reproducible for the estimation of etoricoxib in bulk drug and tablets. The intra-day and inter-day precision were in the range of 0.50 to 0.71 and 0.42 to 0.93 respectively.

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DO - 10.1016/S0731-7085(03)00293-0

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VL - 46

SP - 56

EP - 58

JO - Indian Drugs

JF - Indian Drugs

SN - 0019-462X

IS - 9

ER -