TY - JOUR
T1 - Development of cream to enhance the antifungal activity and reduce the side effects of fluconazole for the treatment of Candida albicans
AU - Bhaskaran, Navya Ajitkumar
AU - Salwa,
AU - Fernandes, Amanda Velinna
AU - Volfová, Gabriela
AU - Pydi, Chinna Raja
AU - Kumar, Lalit
AU - Verma, Ruchi
AU - Marques, Shirleen Miriam
AU - Shirodkar, Rupesh Kalidas
N1 - Funding Information:
Authors are thankful to Ipca Laboratories, Mumbai, India for providing drug as a gift sample. Authors also acknowledge the support of Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India for providing infrastructural facilities.
Publisher Copyright:
© 2022 Walter de Gruyter GmbH, Berlin/Boston.
PY - 2022/5
Y1 - 2022/5
N2 - The aim of the present study was to formulate a fluconazole cream for the treatment of Candida albicans. The optimized cream formulation was prepared using stearic acid, oleic acid, beeswax and borax. The uniform distribution of the active ingredient fluconazole could be confirmed in all formulated creams. The FC-C-C formulation showed satisfactory spreadability and extrudability. FC-C-C delivered (95.07 ± 15.85)% in only 36 h, and the formulation released the drug by an anomalous diffusion mechanism. The viscosity of FC-C-C was found to be (63.20 ± 0.83) cP. The antifungal study and animal studies confirmed that the prepared formulation is non-irritant and has an enhanced antifungal activity that reduces the side effects of fluconazole. The studies confirm that the prepared formulation may be useful for the treatment of Candida albicans.
AB - The aim of the present study was to formulate a fluconazole cream for the treatment of Candida albicans. The optimized cream formulation was prepared using stearic acid, oleic acid, beeswax and borax. The uniform distribution of the active ingredient fluconazole could be confirmed in all formulated creams. The FC-C-C formulation showed satisfactory spreadability and extrudability. FC-C-C delivered (95.07 ± 15.85)% in only 36 h, and the formulation released the drug by an anomalous diffusion mechanism. The viscosity of FC-C-C was found to be (63.20 ± 0.83) cP. The antifungal study and animal studies confirmed that the prepared formulation is non-irritant and has an enhanced antifungal activity that reduces the side effects of fluconazole. The studies confirm that the prepared formulation may be useful for the treatment of Candida albicans.
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U2 - 10.1515/tsd-2022-2422
DO - 10.1515/tsd-2022-2422
M3 - Article
AN - SCOPUS:85128991363
SN - 0932-3414
VL - 59
SP - 231
EP - 239
JO - Tenside, Surfactants, Detergents
JF - Tenside, Surfactants, Detergents
IS - 3
ER -