Development of polyvinlyl alcohol-chitosan-hydroxypropylmethylcellulose based composite films for controlled drug delivery

Saran Gopalakrishnan, Eshwari Dathathri, Goutam Thakur, K. B. Koteshwara

Research output: Contribution to journalArticle

Abstract

The study aims at developing composite films of polyvinyl alcohol (PVA), chitosan (Cs) and Hydroxypropyl-methyl-cellulose (HPMC) using the solvent casting method. The films are developed with enhanced mechanical stability to help in reducing inflammation and providing the initial dressing to aid in wound healing. Films of different polymer ratios were developed and optimized for further characterization studies, the optimal blends were then selected for drug diffusion studies with curcumin. Films of HPMC:chitosan:PVA ratios of 1:1:1 and 1:1:2 have showed improved tensile strength (56.77 MPa and 113.76 MPa respectively), showed more sustained swelling for 25 minutes in comparison to other samples. FTIR analysis and SEM analysis indicated interaction among the polymers while its surface morphology being continuous and uniform. Film HPMC:chitosan:PVA ratio of 1:1:1 (HCP1) exhibited substantially efficient release of 16.38±0.126% over 3 hours and found best fit in zero order following non Fickian diffusion. The film characteristics and diffusion studies indicated that the drug-loaded film could hold good for its application in wound healing.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalTrends in Biomaterials and Artificial Organs
Volume31
Issue number3
Publication statusPublished - 01-01-2017

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine (miscellaneous)

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