Development of solid self-emulsifying formulation for improving the solubility of albendazole

Solid self-emulsifying drug delivery system (S-SEDDS) was developed for solubility improve-ment of poorly water-soluble drug albendazole, which has very less bioavailability of < 5%. The Liquid SEDDS formulation was prepared using peppermint oil, TWEEN 80, and PEG 600. The liquid formulation was subjected to various in vitro evaluation tests. The optimized liquid SEDDS formulation was used for the preparation of S-SEDDS, following physical adsorbent technique, using a mixture of Avicel PH 101 and Aerosil 200 in the ratio of 1:0.5 as an inert solid adsorbent in 1:4 ratio of liquid SEDDS:adsorbent. The prepared S-SEDDS converted to free-flowing granules by wet granulation methods, using 1% PVP solution in IPA. Optimized S-SEDDS were evaluated. In vitro dissolution studies showed a significant in-crease in dissolution rate of the drug when formulated as solid SEDDS %: at 60 min was found to be 99.02 ± 0.7 % while the pure drug was 27.39 ± 1.6 %.