Development of the fetal ureter

A fetal metric and histological study

Priya J. Martis, Anne D. Souza, Vidya Monappa, Nandini Prashanth Bhat, Sneha Guruprasad Kalthur

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: This study provides a description of development of various components of the human ureter at different gestational ages. Methods: Measurements of the length of the ureter from pelvi-ureteric junction to vesico-ureteric junction, length of its intravesicular portion and angle made by the ureter at the entry into the bladder with respect to the internal ureteric orifice were taken. Transverse sections of the ureter were taken at the upper end, close to the pelvi-ureteric junction, and at the midpoint between the pelvis of the kidney and the vesico-ureteric junction. These were subjected for processing and stained with Haematoxylin Eosin and Masson's Trichrome. They were then studied under the light microscope. Results: The length of the ureter from the pelvi-ureteric junction to the vesico-ureteric junction showed a highly positive correlation with the gestational age (GA). The angle of entry of the ureter to the bladder decreased as the GA increased. The microstructure of the ureter in both the sections showed development of transitional epithelium with an increase in layers by 33 weeks. At 18 weeks, the smooth muscle layer was in a single layer with an abundance of interspersed collagen fibers. By 33 weeks, the thickness of the wall increased significantly with a decrease in collagen. There was no trace of longitudinal muscle fibers even upto 33 weeks. Conclusion: Epithelial, muscular and connective tissue components displayed significant changes during intra uterine development.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalMalaysian Journal of Medicine and Health Sciences
Volume14
Issue number1
Publication statusPublished - 01-01-2018

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Ureter
Fetal Development
Gestational Age
Urinary Bladder
Collagen
Epithelium
Kidney Pelvis
Hematoxylin
Eosine Yellowish-(YS)
Connective Tissue
Smooth Muscle
Light
Muscles

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Development of the fetal ureter: A fetal metric and histological study",
abstract = "Introduction: This study provides a description of development of various components of the human ureter at different gestational ages. Methods: Measurements of the length of the ureter from pelvi-ureteric junction to vesico-ureteric junction, length of its intravesicular portion and angle made by the ureter at the entry into the bladder with respect to the internal ureteric orifice were taken. Transverse sections of the ureter were taken at the upper end, close to the pelvi-ureteric junction, and at the midpoint between the pelvis of the kidney and the vesico-ureteric junction. These were subjected for processing and stained with Haematoxylin Eosin and Masson's Trichrome. They were then studied under the light microscope. Results: The length of the ureter from the pelvi-ureteric junction to the vesico-ureteric junction showed a highly positive correlation with the gestational age (GA). The angle of entry of the ureter to the bladder decreased as the GA increased. The microstructure of the ureter in both the sections showed development of transitional epithelium with an increase in layers by 33 weeks. At 18 weeks, the smooth muscle layer was in a single layer with an abundance of interspersed collagen fibers. By 33 weeks, the thickness of the wall increased significantly with a decrease in collagen. There was no trace of longitudinal muscle fibers even upto 33 weeks. Conclusion: Epithelial, muscular and connective tissue components displayed significant changes during intra uterine development.",
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Development of the fetal ureter : A fetal metric and histological study. / Martis, Priya J.; Souza, Anne D.; Monappa, Vidya; Bhat, Nandini Prashanth; Kalthur, Sneha Guruprasad.

In: Malaysian Journal of Medicine and Health Sciences, Vol. 14, No. 1, 01.01.2018, p. 15-20.

Research output: Contribution to journalArticle

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