Developmental and behavioral consequences of prenatal fluoxetine

K. L. Bairy, S. Madhyastha, K. P. Ashok, Indira Bairy, S. Malini

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Background: Fluoxetine, a selective serotonin reuptake inhibitor, is the most commonly prescribed antidepressant drug for pregnant women. Studies regarding the teratogenic effect of fluoxetine on human and animal models are mainly concerned with structural malformation (congenital anomalies). Aim: Hence, the present study was planned to evaluate the postnatal behavioral effects of fluoxetine on albino rats. Methods: Three groups of female rats received either distilled water or doses of fluoxetine 8 and 12 mg/kg orally from the 6th to the 20th day of pregnancy. Weaning of the pups was done on the 21st day followed by a battery of behavioral tests to assess for any behavioral effect. The tests included negative geotaxis, open field exploration, rota-rod test, elevated plus maze and passive avoidance test. Results: In the present study there was no change in the gestational length of pregnancy, no premature birth or miscarriage during pregnancy. A high dose of in utero fluoxetine resulted in a decrease in birth weight of the offspring and also reduced weight gain during the preweaning period. No major congenital abnormalities were observed in the offspring exposed to fluoxetine. Prenatal fluoxetine exposure at high dose caused an initial transient delay in motor development and this poor motor activity was transient and not permanent. However, prenatal exposure to fluoxetine at a higher dose showed a favorable effect on learning and memory in water maze and passive avoidance tests. Conclusions: From the present study, it may be concluded that prenatal fluoxetine causes a transient delay in motor development but does not adversely affect the postnatal behavioral consequences.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalPharmacology
Volume79
Issue number1
DOIs
Publication statusPublished - 01-01-2007

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Fluoxetine
Pregnancy
Water
Premature Birth
Serotonin Uptake Inhibitors
Spontaneous Abortion
Weaning
Birth Weight
Antidepressive Agents
Weight Gain
Pregnant Women
Motor Activity
Animal Models
Learning

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Bairy, K. L., Madhyastha, S., Ashok, K. P., Bairy, I., & Malini, S. (2007). Developmental and behavioral consequences of prenatal fluoxetine. Pharmacology, 79(1), 1-11. https://doi.org/10.1159/000096645
Bairy, K. L. ; Madhyastha, S. ; Ashok, K. P. ; Bairy, Indira ; Malini, S. / Developmental and behavioral consequences of prenatal fluoxetine. In: Pharmacology. 2007 ; Vol. 79, No. 1. pp. 1-11.
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Bairy, KL, Madhyastha, S, Ashok, KP, Bairy, I & Malini, S 2007, 'Developmental and behavioral consequences of prenatal fluoxetine', Pharmacology, vol. 79, no. 1, pp. 1-11. https://doi.org/10.1159/000096645

Developmental and behavioral consequences of prenatal fluoxetine. / Bairy, K. L.; Madhyastha, S.; Ashok, K. P.; Bairy, Indira; Malini, S.

In: Pharmacology, Vol. 79, No. 1, 01.01.2007, p. 1-11.

Research output: Contribution to journalArticle

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