Dexmedetomidine as an adjunct in laparoscopic surgery along with entropy as a tool to measure the anaesthetic depth

Shivani Bakshi, Madhusudan Upadya, Julie C.R. Misquith

Research output: Contribution to journalArticle

Abstract

Introduction: Dexmedetomidine is a drug that can be used for various anaesthetic indications such as an adjuvant for general anaesthesia and regional blocks, in premedication, as a hypnotic and analgesic postoperatively. Aim: To study the effect of dexmedetomidine as an adjuvant in anaesthesia for laparoscopic surgery using entropy as an instrument to monitor the anaesthetic depth. Methods and materials: Sixty patients were enrolled for the study, thirty receiving dexmedetomidine infusion (group 1) and thirty receiving saline infusion (group 2). Prior to induction, an entropy sensor was positioned as per manufacturer’s recommendation. Patients received a loading dose of given drug, either dexmedetomidine or saline, followed by an infusion for maintenance. All patients were given general anaesthesia with propofol and fentanyl. The given drug infusion was continued until extubation. Results: Mean systolic and diastolic blood pressure during extubation showed 5% and 8.5% increase respectively from baseline in the dexmedetomidine group (p>0.050) as compared to 19% and 15% increase respectively in the saline group which was significant (p<0.05). The dose of propofol used was reduced significantly; mean dose requirement for induction was 59±22.07 in group 1 as compared to 97.74±27.044 in group 2. There was marked reduction in the opioid requirement intraoperatively in group1 (21.66±27.64) as compared to group 2 (41.613±28.384) with adequate depth of anaesthesia (DOA) maintained. Conclusion: Dexmedetomidine is an effectual anaesthetic adjunct that can be used in laparoscopic surgeries with an excellent recovery profile and provides adequate depth of anaesthesia.

Original languageEnglish
Pages (from-to)120-126
Number of pages7
JournalSri Lankan Journal of Anaesthesiology
Volume27
Issue number2
DOIs
Publication statusPublished - 01-01-2019

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Dexmedetomidine
Entropy
Laparoscopy
Anesthetics
Propofol
General Anesthesia
Anesthesia Adjuvants
Anesthesia
Pharmaceutical Preparations
Blood Pressure
Premedication
Fentanyl
Hypnotics and Sedatives
Opioid Analgesics
Analgesics
Maintenance

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

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title = "Dexmedetomidine as an adjunct in laparoscopic surgery along with entropy as a tool to measure the anaesthetic depth",
abstract = "Introduction: Dexmedetomidine is a drug that can be used for various anaesthetic indications such as an adjuvant for general anaesthesia and regional blocks, in premedication, as a hypnotic and analgesic postoperatively. Aim: To study the effect of dexmedetomidine as an adjuvant in anaesthesia for laparoscopic surgery using entropy as an instrument to monitor the anaesthetic depth. Methods and materials: Sixty patients were enrolled for the study, thirty receiving dexmedetomidine infusion (group 1) and thirty receiving saline infusion (group 2). Prior to induction, an entropy sensor was positioned as per manufacturer’s recommendation. Patients received a loading dose of given drug, either dexmedetomidine or saline, followed by an infusion for maintenance. All patients were given general anaesthesia with propofol and fentanyl. The given drug infusion was continued until extubation. Results: Mean systolic and diastolic blood pressure during extubation showed 5{\%} and 8.5{\%} increase respectively from baseline in the dexmedetomidine group (p>0.050) as compared to 19{\%} and 15{\%} increase respectively in the saline group which was significant (p<0.05). The dose of propofol used was reduced significantly; mean dose requirement for induction was 59±22.07 in group 1 as compared to 97.74±27.044 in group 2. There was marked reduction in the opioid requirement intraoperatively in group1 (21.66±27.64) as compared to group 2 (41.613±28.384) with adequate depth of anaesthesia (DOA) maintained. Conclusion: Dexmedetomidine is an effectual anaesthetic adjunct that can be used in laparoscopic surgeries with an excellent recovery profile and provides adequate depth of anaesthesia.",
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Dexmedetomidine as an adjunct in laparoscopic surgery along with entropy as a tool to measure the anaesthetic depth. / Bakshi, Shivani; Upadya, Madhusudan; Misquith, Julie C.R.

In: Sri Lankan Journal of Anaesthesiology, Vol. 27, No. 2, 01.01.2019, p. 120-126.

Research output: Contribution to journalArticle

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AU - Upadya, Madhusudan

AU - Misquith, Julie C.R.

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