Diabetes mellitus and metformin: Fatal vitamin B12 deficiency associated with anemia and sepsis in a young adult

Anuvarsha Katroth, Anusha Narayanam, Sheetal Chauan, Ajit Singh

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1 Citation (Scopus)


Metformin is recommended as the first-line therapy to treat type 2 diabetes mellitus with better efficacy. We present a young adult with severe fatigue and dyspnea along with difficulty during the walk and tingling sensation in both the lower limbs. He had T2DM for 9 years and continuing metformin 1 g daily for five years. He presented to the hospital with untreated wounds over lower limbs. His haematological reports showed the megaloblastic anemia and transfused with several pints of packed red blood cells (PRBCs). The patient developed sepsis during hospitalization and started on antibiotics. After several PRBC transfusions and aggressive treatment also patient did not improve and succumbed on 5th day of hospitalization.

Original languageEnglish
Pages (from-to)165-167
Number of pages3
JournalJournal of Applied Pharmaceutical Science
Issue number3
Publication statusPublished - 01-03-2018
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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