Diabetes mellitus and metformin

Fatal vitamin B12 deficiency associated with anemia and sepsis in a young adult

Anuvarsha Katroth, Anusha Narayanam, Sheetal Chauan, Ajit Singh

Research output: Contribution to journalArticle

Abstract

Metformin is recommended as the first-line therapy to treat type 2 diabetes mellitus with better efficacy. We present a young adult with severe fatigue and dyspnea along with difficulty during the walk and tingling sensation in both the lower limbs. He had T2DM for 9 years and continuing metformin 1 g daily for five years. He presented to the hospital with untreated wounds over lower limbs. His haematological reports showed the megaloblastic anemia and transfused with several pints of packed red blood cells (PRBCs). The patient developed sepsis during hospitalization and started on antibiotics. After several PRBC transfusions and aggressive treatment also patient did not improve and succumbed on 5th day of hospitalization.

Original languageEnglish
Pages (from-to)165-167
Number of pages3
JournalJournal of Applied Pharmaceutical Science
Volume8
Issue number3
DOIs
Publication statusPublished - 01-03-2018
Externally publishedYes

Fingerprint

Vitamin B 12 Deficiency
Metformin
Anemia
Young Adult
Lower Extremity
Sepsis
Diabetes Mellitus
Hospitalization
Megaloblastic Anemia
Erythrocyte Transfusion
Dyspnea
Type 2 Diabetes Mellitus
Fatigue
Erythrocytes
Anti-Bacterial Agents
Wounds and Injuries
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Katroth, Anuvarsha ; Narayanam, Anusha ; Chauan, Sheetal ; Singh, Ajit. / Diabetes mellitus and metformin : Fatal vitamin B12 deficiency associated with anemia and sepsis in a young adult. In: Journal of Applied Pharmaceutical Science. 2018 ; Vol. 8, No. 3. pp. 165-167.
@article{2d98fe6965e043a3ac0d8dc266530eea,
title = "Diabetes mellitus and metformin: Fatal vitamin B12 deficiency associated with anemia and sepsis in a young adult",
abstract = "Metformin is recommended as the first-line therapy to treat type 2 diabetes mellitus with better efficacy. We present a young adult with severe fatigue and dyspnea along with difficulty during the walk and tingling sensation in both the lower limbs. He had T2DM for 9 years and continuing metformin 1 g daily for five years. He presented to the hospital with untreated wounds over lower limbs. His haematological reports showed the megaloblastic anemia and transfused with several pints of packed red blood cells (PRBCs). The patient developed sepsis during hospitalization and started on antibiotics. After several PRBC transfusions and aggressive treatment also patient did not improve and succumbed on 5th day of hospitalization.",
author = "Anuvarsha Katroth and Anusha Narayanam and Sheetal Chauan and Ajit Singh",
year = "2018",
month = "3",
day = "1",
doi = "10.7324/JAPS.2018.8322",
language = "English",
volume = "8",
pages = "165--167",
journal = "Journal of Applied Pharmaceutical Science",
issn = "2231-3354",
publisher = "MediPoeia",
number = "3",

}

Diabetes mellitus and metformin : Fatal vitamin B12 deficiency associated with anemia and sepsis in a young adult. / Katroth, Anuvarsha; Narayanam, Anusha; Chauan, Sheetal; Singh, Ajit.

In: Journal of Applied Pharmaceutical Science, Vol. 8, No. 3, 01.03.2018, p. 165-167.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Diabetes mellitus and metformin

T2 - Fatal vitamin B12 deficiency associated with anemia and sepsis in a young adult

AU - Katroth, Anuvarsha

AU - Narayanam, Anusha

AU - Chauan, Sheetal

AU - Singh, Ajit

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Metformin is recommended as the first-line therapy to treat type 2 diabetes mellitus with better efficacy. We present a young adult with severe fatigue and dyspnea along with difficulty during the walk and tingling sensation in both the lower limbs. He had T2DM for 9 years and continuing metformin 1 g daily for five years. He presented to the hospital with untreated wounds over lower limbs. His haematological reports showed the megaloblastic anemia and transfused with several pints of packed red blood cells (PRBCs). The patient developed sepsis during hospitalization and started on antibiotics. After several PRBC transfusions and aggressive treatment also patient did not improve and succumbed on 5th day of hospitalization.

AB - Metformin is recommended as the first-line therapy to treat type 2 diabetes mellitus with better efficacy. We present a young adult with severe fatigue and dyspnea along with difficulty during the walk and tingling sensation in both the lower limbs. He had T2DM for 9 years and continuing metformin 1 g daily for five years. He presented to the hospital with untreated wounds over lower limbs. His haematological reports showed the megaloblastic anemia and transfused with several pints of packed red blood cells (PRBCs). The patient developed sepsis during hospitalization and started on antibiotics. After several PRBC transfusions and aggressive treatment also patient did not improve and succumbed on 5th day of hospitalization.

UR - http://www.scopus.com/inward/record.url?scp=85044746575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044746575&partnerID=8YFLogxK

U2 - 10.7324/JAPS.2018.8322

DO - 10.7324/JAPS.2018.8322

M3 - Article

VL - 8

SP - 165

EP - 167

JO - Journal of Applied Pharmaceutical Science

JF - Journal of Applied Pharmaceutical Science

SN - 2231-3354

IS - 3

ER -