Abstract

Patients with diabetes mellitus (DM) are prone to develop heart failure even in the absence of evident hypertension and coronary artery disease. This entity is difficult to detect in early stages by conventional echocardiographic techniques. 32 asymptomatic TMT (tread mill stress test) negative DM patients compared with control subjects were screened and performed LV (left ventricle) strain, strain rate and tissue Doppler imaging. Tissue Doppler imaging revealed increased E/E' of IVS (Inter ventricular septum) (p value<0.001) among DM suggestive of diastolic dysfunction. The tissue velocities E' of both the LV lateral wall (p value=0.004) and RV (right ventricle) (p value =0.003) were reduced among DM. Similarly, the peak systolic strain (p value<0.001), and strain rate (p value<0.001) were significantly reduced among diabetic subjects. DM is an independent risk factor for myocardial dysfunction even in asymptomatic normotensive subjects. The changes that occur in the myocardium due to diabetic cardiomyopathy can be detected early, as the novel tissue Doppler is a noninvasive technique for early detection of Diabetic cardiomyopathy.

Original languageEnglish
Pages (from-to)1535-1540
Number of pages6
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume7
Issue number1
Publication statusPublished - 01-01-2016

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Diabetic Cardiomyopathies
Medical problems
Diabetes Mellitus
Tissue
Imaging techniques
Heart Ventricles
Strain rate
Ventricular Septum
Exercise Test
Coronary Artery Disease
Myocardium
Heart Failure
Hypertension

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Diabetic cardiomyopathy: Tissue doppler imaging a novel insight",
abstract = "Patients with diabetes mellitus (DM) are prone to develop heart failure even in the absence of evident hypertension and coronary artery disease. This entity is difficult to detect in early stages by conventional echocardiographic techniques. 32 asymptomatic TMT (tread mill stress test) negative DM patients compared with control subjects were screened and performed LV (left ventricle) strain, strain rate and tissue Doppler imaging. Tissue Doppler imaging revealed increased E/E' of IVS (Inter ventricular septum) (p value<0.001) among DM suggestive of diastolic dysfunction. The tissue velocities E' of both the LV lateral wall (p value=0.004) and RV (right ventricle) (p value =0.003) were reduced among DM. Similarly, the peak systolic strain (p value<0.001), and strain rate (p value<0.001) were significantly reduced among diabetic subjects. DM is an independent risk factor for myocardial dysfunction even in asymptomatic normotensive subjects. The changes that occur in the myocardium due to diabetic cardiomyopathy can be detected early, as the novel tissue Doppler is a noninvasive technique for early detection of Diabetic cardiomyopathy.",
author = "Rao, {Karthik N.} and Kirthinath Ballala and Jyothi Samanth and Ranjan Shetty and Sudha Vidyasagar and Krishnananda Nayak and Maiya, {Arun G.} and Shashi Kumar and Usha Nandhini",
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Diabetic cardiomyopathy : Tissue doppler imaging a novel insight. / Rao, Karthik N.; Ballala, Kirthinath; Samanth, Jyothi; Shetty, Ranjan; Vidyasagar, Sudha; Nayak, Krishnananda; Maiya, Arun G.; Kumar, Shashi; Nandhini, Usha.

In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 7, No. 1, 01.01.2016, p. 1535-1540.

Research output: Contribution to journalArticle

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AU - Rao, Karthik N.

AU - Ballala, Kirthinath

AU - Samanth, Jyothi

AU - Shetty, Ranjan

AU - Vidyasagar, Sudha

AU - Nayak, Krishnananda

AU - Maiya, Arun G.

AU - Kumar, Shashi

AU - Nandhini, Usha

PY - 2016/1/1

Y1 - 2016/1/1

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