Diagnostic pitfalls in papillary lesions of the breast

Experience from a single tertiary care center

Sridevi Hanaganahalli Basavaiah, Jessica Minal, Saraswathy Sreeram, Pooja Kundapur Suresh, Hema Kini, Deepa Adiga, Kausalya Kumari Sahu, Radha R. Pai

Research output: Contribution to journalArticle

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Abstract

Introduction: Papillary neoplasms are a group of lesions that are characterized by presence of papillae supported by fibrovascular cores lined by epithelial cells with or without myoepithelial cell layer. These neoplasms may be benign, atypical or malignant. Aims: This studywas conducted toanalyse theclinicopathological characteristics of papillary lesions of the breast. Materials and Methods: A retrospective and prospective analysis of 34 cases of papillary lesions received over a period of 7 years from 2009 to 2015 was done. The patient’s clinical details were collected from medical archives and the histopathological findings were reviewed. The lesions were classified into benign, atypical and malignant categories. Results: During the study period, there were 34 cases of papillary lesions of breast. The mean age was 58 years. The central quadrant was the most common location (66.6%). The most common presenting complaint was lump (76.5% cases). Papillary lesions presented more commonly as solitary lump (82.4%) rather than multifocal disease. Benign papillary lesions were more common than the atypical and malignant lesions. The most common papillary lesion accounting for 43% of the cases was intraductal papilloma. Malignant lesions accounted for 41.2% cases with intraductal papillary carcinoma and invasive papillary carcinoma constituting 14.7% cases each. Conclusion: Diagnosis of papillary carcinoma is challenging and its classification includes different entities that have specific diagnostic criteria. Due to their heterozygosity in morphology with benign, atypical and malignant subtypes, morphological features such as type of fibrovascular core and continuity of myoepithelial layer along with immunohistochemical stains for myoepithelial cells should be considered for proper and accurate diagnosis.

Original languageEnglish
Pages (from-to)EC18-EC21
JournalJournal of Clinical and Diagnostic Research
Volume10
Issue number8
DOIs
Publication statusPublished - 01-08-2016

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Papillary Carcinoma
Tertiary Care Centers
Breast
Intraductal Papilloma
Carcinoma, Intraductal, Noninfiltrating
Coloring Agents
Cells
Neoplasms
Epithelial Cells

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

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title = "Diagnostic pitfalls in papillary lesions of the breast: Experience from a single tertiary care center",
abstract = "Introduction: Papillary neoplasms are a group of lesions that are characterized by presence of papillae supported by fibrovascular cores lined by epithelial cells with or without myoepithelial cell layer. These neoplasms may be benign, atypical or malignant. Aims: This studywas conducted toanalyse theclinicopathological characteristics of papillary lesions of the breast. Materials and Methods: A retrospective and prospective analysis of 34 cases of papillary lesions received over a period of 7 years from 2009 to 2015 was done. The patient’s clinical details were collected from medical archives and the histopathological findings were reviewed. The lesions were classified into benign, atypical and malignant categories. Results: During the study period, there were 34 cases of papillary lesions of breast. The mean age was 58 years. The central quadrant was the most common location (66.6{\%}). The most common presenting complaint was lump (76.5{\%} cases). Papillary lesions presented more commonly as solitary lump (82.4{\%}) rather than multifocal disease. Benign papillary lesions were more common than the atypical and malignant lesions. The most common papillary lesion accounting for 43{\%} of the cases was intraductal papilloma. Malignant lesions accounted for 41.2{\%} cases with intraductal papillary carcinoma and invasive papillary carcinoma constituting 14.7{\%} cases each. Conclusion: Diagnosis of papillary carcinoma is challenging and its classification includes different entities that have specific diagnostic criteria. Due to their heterozygosity in morphology with benign, atypical and malignant subtypes, morphological features such as type of fibrovascular core and continuity of myoepithelial layer along with immunohistochemical stains for myoepithelial cells should be considered for proper and accurate diagnosis.",
author = "Basavaiah, {Sridevi Hanaganahalli} and Jessica Minal and Saraswathy Sreeram and Suresh, {Pooja Kundapur} and Hema Kini and Deepa Adiga and Sahu, {Kausalya Kumari} and Pai, {Radha R.}",
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Diagnostic pitfalls in papillary lesions of the breast : Experience from a single tertiary care center. / Basavaiah, Sridevi Hanaganahalli; Minal, Jessica; Sreeram, Saraswathy; Suresh, Pooja Kundapur; Kini, Hema; Adiga, Deepa; Sahu, Kausalya Kumari; Pai, Radha R.

In: Journal of Clinical and Diagnostic Research, Vol. 10, No. 8, 01.08.2016, p. EC18-EC21.

Research output: Contribution to journalArticle

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T1 - Diagnostic pitfalls in papillary lesions of the breast

T2 - Experience from a single tertiary care center

AU - Basavaiah, Sridevi Hanaganahalli

AU - Minal, Jessica

AU - Sreeram, Saraswathy

AU - Suresh, Pooja Kundapur

AU - Kini, Hema

AU - Adiga, Deepa

AU - Sahu, Kausalya Kumari

AU - Pai, Radha R.

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Y1 - 2016/8/1

N2 - Introduction: Papillary neoplasms are a group of lesions that are characterized by presence of papillae supported by fibrovascular cores lined by epithelial cells with or without myoepithelial cell layer. These neoplasms may be benign, atypical or malignant. Aims: This studywas conducted toanalyse theclinicopathological characteristics of papillary lesions of the breast. Materials and Methods: A retrospective and prospective analysis of 34 cases of papillary lesions received over a period of 7 years from 2009 to 2015 was done. The patient’s clinical details were collected from medical archives and the histopathological findings were reviewed. The lesions were classified into benign, atypical and malignant categories. Results: During the study period, there were 34 cases of papillary lesions of breast. The mean age was 58 years. The central quadrant was the most common location (66.6%). The most common presenting complaint was lump (76.5% cases). Papillary lesions presented more commonly as solitary lump (82.4%) rather than multifocal disease. Benign papillary lesions were more common than the atypical and malignant lesions. The most common papillary lesion accounting for 43% of the cases was intraductal papilloma. Malignant lesions accounted for 41.2% cases with intraductal papillary carcinoma and invasive papillary carcinoma constituting 14.7% cases each. Conclusion: Diagnosis of papillary carcinoma is challenging and its classification includes different entities that have specific diagnostic criteria. Due to their heterozygosity in morphology with benign, atypical and malignant subtypes, morphological features such as type of fibrovascular core and continuity of myoepithelial layer along with immunohistochemical stains for myoepithelial cells should be considered for proper and accurate diagnosis.

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