TY - JOUR
T1 - Diagnostic strategies for subclinical hypothyroidism
AU - Mohanty, Shruti
AU - Amruthlal, W.
AU - Reddy, G. C.
AU - Kusumanjali, G.
AU - Kanagasabapathy, A. S.
AU - Rao, Pragna
PY - 2008
Y1 - 2008
N2 - The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are clinically symptomatic but may have a normal thyroid profile. Tri - iodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74 % of study subjects had elevated anti-TPO levels.61 % patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels (73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk of developing overt hypothyroidism.
AB - The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are clinically symptomatic but may have a normal thyroid profile. Tri - iodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74 % of study subjects had elevated anti-TPO levels.61 % patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels (73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk of developing overt hypothyroidism.
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U2 - 10.1007/s12291-008-0062-y
DO - 10.1007/s12291-008-0062-y
M3 - Article
AN - SCOPUS:56749185744
SN - 0970-1915
VL - 23
SP - 279
EP - 282
JO - Indian Journal of Clinical Biochemistry
JF - Indian Journal of Clinical Biochemistry
IS - 3
ER -