Diagnostic strategies for subclinical hypothyroidism

Shruti Mohanty, W. Amruthlal, G. C. Reddy, G. Kusumanjali, A. S. Kanagasabapathy, Pragna Rao

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are clinically symptomatic but may have a normal thyroid profile. Tri - iodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74 % of study subjects had elevated anti-TPO levels.61 % patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels (73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk of developing overt hypothyroidism.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalIndian Journal of Clinical Biochemistry
Volume23
Issue number3
DOIs
Publication statusPublished - 2008

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Iodide Peroxidase
Hypothyroidism
Antibodies
Thyroxine
Thyroid Gland
Thyrotropin
Blood
Fasting

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Mohanty, S., Amruthlal, W., Reddy, G. C., Kusumanjali, G., Kanagasabapathy, A. S., & Rao, P. (2008). Diagnostic strategies for subclinical hypothyroidism. Indian Journal of Clinical Biochemistry, 23(3), 279-282. https://doi.org/10.1007/s12291-008-0062-y
Mohanty, Shruti ; Amruthlal, W. ; Reddy, G. C. ; Kusumanjali, G. ; Kanagasabapathy, A. S. ; Rao, Pragna. / Diagnostic strategies for subclinical hypothyroidism. In: Indian Journal of Clinical Biochemistry. 2008 ; Vol. 23, No. 3. pp. 279-282.
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Mohanty, S, Amruthlal, W, Reddy, GC, Kusumanjali, G, Kanagasabapathy, AS & Rao, P 2008, 'Diagnostic strategies for subclinical hypothyroidism', Indian Journal of Clinical Biochemistry, vol. 23, no. 3, pp. 279-282. https://doi.org/10.1007/s12291-008-0062-y

Diagnostic strategies for subclinical hypothyroidism. / Mohanty, Shruti; Amruthlal, W.; Reddy, G. C.; Kusumanjali, G.; Kanagasabapathy, A. S.; Rao, Pragna.

In: Indian Journal of Clinical Biochemistry, Vol. 23, No. 3, 2008, p. 279-282.

Research output: Contribution to journalArticle

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AU - Reddy, G. C.

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Mohanty S, Amruthlal W, Reddy GC, Kusumanjali G, Kanagasabapathy AS, Rao P. Diagnostic strategies for subclinical hypothyroidism. Indian Journal of Clinical Biochemistry. 2008;23(3):279-282. https://doi.org/10.1007/s12291-008-0062-y