Diagnostic strategies for subclinical hypothyroidism

Shruti Mohanty, W. Amruthlal, G. C. Reddy, G. Kusumanjali, A. S. Kanagasabapathy, Pragna Rao

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are clinically symptomatic but may have a normal thyroid profile. Tri - iodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74 % of study subjects had elevated anti-TPO levels.61 % patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels (73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk of developing overt hypothyroidism.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalIndian Journal of Clinical Biochemistry
Issue number3
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry


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