Differential diagnosis of lung lesion in breast carcinoma: A metachronous neoplasm or metastasis?

Raja Naga Mahesh Maddala, Karthik Udupa, Joseph Thomas, Kanthilatha Pai

Research output: Contribution to journalArticle

Abstract

A 34-year-old woman-a diagnosed case of pT1N1MO, stage IIa, estrogen and progesterone receptor positive (ER, PR) positive, Her2 negative carcinoma of the left breast-was managed with modified radical mastectomy and adjuvant chemotherapy. While planning for radiotherapy, she was found to have a well-defined enhancing lesion with spiculated margins in the superior segment of the right lower lobe along with a heterogeneously enhancing right hilar lymph node on CT. Histopathological evaluation of the lesion was suggestive of adenocarcinoma. The lesion was negative for ER, PR receptors, mammoglobin and gross cystic disease fluid protein. Thyroid transcription factor 1 (TTF-1) was positive, suggesting a primary lung adenocarcinoma rather than metastatic lesion from the breast. This case clearly signifies the importance of histopathological diagnosis of suspicious metastatic lesions in the setting of early breast cancer. We would also like to highlight the importance of TTF-1 in differentiating primary lung malignancy from metastasis.

Original languageEnglish
Article number215125
JournalBMJ Case Reports
Volume2016
DOIs
Publication statusPublished - 11-05-2016

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Second Primary Neoplasms
Progesterone Receptors
Estrogen Receptors
Differential Diagnosis
Breast Neoplasms
Neoplasm Metastasis
Modified Radical Mastectomy
Lung
Adjuvant Chemotherapy
Adenocarcinoma
Breast
Radiotherapy
Lymph Nodes
Neoplasms
Proteins
thyroid nuclear factor 1
Adenocarcinoma of lung

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Differential diagnosis of lung lesion in breast carcinoma: A metachronous neoplasm or metastasis?",
abstract = "A 34-year-old woman-a diagnosed case of pT1N1MO, stage IIa, estrogen and progesterone receptor positive (ER, PR) positive, Her2 negative carcinoma of the left breast-was managed with modified radical mastectomy and adjuvant chemotherapy. While planning for radiotherapy, she was found to have a well-defined enhancing lesion with spiculated margins in the superior segment of the right lower lobe along with a heterogeneously enhancing right hilar lymph node on CT. Histopathological evaluation of the lesion was suggestive of adenocarcinoma. The lesion was negative for ER, PR receptors, mammoglobin and gross cystic disease fluid protein. Thyroid transcription factor 1 (TTF-1) was positive, suggesting a primary lung adenocarcinoma rather than metastatic lesion from the breast. This case clearly signifies the importance of histopathological diagnosis of suspicious metastatic lesions in the setting of early breast cancer. We would also like to highlight the importance of TTF-1 in differentiating primary lung malignancy from metastasis.",
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Differential diagnosis of lung lesion in breast carcinoma : A metachronous neoplasm or metastasis? / Maddala, Raja Naga Mahesh; Udupa, Karthik; Thomas, Joseph; Pai, Kanthilatha.

In: BMJ Case Reports, Vol. 2016, 215125, 11.05.2016.

Research output: Contribution to journalArticle

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AU - Maddala, Raja Naga Mahesh

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AU - Thomas, Joseph

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