Differentiation of Crohn's disease from intestinal tuberculosis in India in 2010

Anna Benjamin Pulimood, Deepak Narayan Amarapurkar, Ujjala Ghoshal, Mathew Phillip, Cannanore Ganesh Pai, Duvvur Nageshwar Reddy, Birender Nagi, Balakrishna Siddhartha Ramakrishna

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Differentiating intestinal tuberculosis from Crohn's disease (CD) is an important clinical challenge of considerable therapeutic significance. The problem is of greatest magnitude in countries where tuberculosis continues to be highly prevalent, and where the incidence of CD is increasing. The final clinical diagnosis is based on a combination of the clinical history with endoscopic studies, culture and polymerase chain reaction for Mycobacterium tuberculosis, biopsy pathology, radiological investigations and response to therapy. In a subset of patients, surgery is required and intraoperative findings with pathological study of the resected bowel provide a definitive diagnosis. Awareness of the parameters useful in distinguishing these two disorders in each of the different diagnostic modalities is crucial to accurate decision making. Newer techniques, such as capsule endoscopy, small bowel enteroscopy and immunological assays for Mycobacterium tuberculosis, have a role to play in the differentiation of intestinal tuberculosis and CD. This review presents currently available evidence regarding the usefulness and limitations of all these different modalities available for the evaluation of these two disorders.

Original languageEnglish
Pages (from-to)433-443
Number of pages11
JournalWorld Journal of Gastroenterology
Volume17
Issue number4
DOIs
Publication statusPublished - 28-01-2011

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Crohn Disease
India
Tuberculosis
Mycobacterium tuberculosis
Capsule Endoscopy
Intestinal Diseases
Decision Making
Pathology
Biopsy
Polymerase Chain Reaction
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Pulimood, A. B., Amarapurkar, D. N., Ghoshal, U., Phillip, M., Pai, C. G., Reddy, D. N., ... Ramakrishna, B. S. (2011). Differentiation of Crohn's disease from intestinal tuberculosis in India in 2010. World Journal of Gastroenterology, 17(4), 433-443. https://doi.org/10.3748/wjg.v17.i4.433
Pulimood, Anna Benjamin ; Amarapurkar, Deepak Narayan ; Ghoshal, Ujjala ; Phillip, Mathew ; Pai, Cannanore Ganesh ; Reddy, Duvvur Nageshwar ; Nagi, Birender ; Ramakrishna, Balakrishna Siddhartha. / Differentiation of Crohn's disease from intestinal tuberculosis in India in 2010. In: World Journal of Gastroenterology. 2011 ; Vol. 17, No. 4. pp. 433-443.
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Pulimood, AB, Amarapurkar, DN, Ghoshal, U, Phillip, M, Pai, CG, Reddy, DN, Nagi, B & Ramakrishna, BS 2011, 'Differentiation of Crohn's disease from intestinal tuberculosis in India in 2010', World Journal of Gastroenterology, vol. 17, no. 4, pp. 433-443. https://doi.org/10.3748/wjg.v17.i4.433

Differentiation of Crohn's disease from intestinal tuberculosis in India in 2010. / Pulimood, Anna Benjamin; Amarapurkar, Deepak Narayan; Ghoshal, Ujjala; Phillip, Mathew; Pai, Cannanore Ganesh; Reddy, Duvvur Nageshwar; Nagi, Birender; Ramakrishna, Balakrishna Siddhartha.

In: World Journal of Gastroenterology, Vol. 17, No. 4, 28.01.2011, p. 433-443.

Research output: Contribution to journalArticle

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