Diminution of singlet oxygen-induced DNA damage by curcmin and related antioxidants

M. Subramanian, Sreejayan [No Value], T.P.A. Devasagayam, B.B. Singh

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

Curcumin, the natural antioxidant from turmeric, an Indian spice, and its derivatives have significant abilities to protect plasmid pBR322 against single-strand breaks induced by singlet oxygen (1O2), a reactive oxygen species with potential genotoxic/mutagenic properties. 1O2 was generated at 37°C in an aqueous buffer system by the thermal dissociation of the endoperoxide of 3,3′-(1,4-naphthylene)dipropionate (NDPO2). Among the compounds, tested, curcumin was the most effective inhibitor of DNA damage followed by desmethoxycurcumin, bisdesmethoxycurcumin and other derivatives. The observed antioxidant activity was both time-and concentration-dependent. The protectice ability of curcumin was higher than that of the well-known biological antioxidants lipoate, α-tocopherol and β-carotene. However, the highest protective ability with saturating concentrations of curcumin did not exceed 50%. The ability of curcumin and its derivatives to protect DNA against 1O2 seems to be related to their structures and may at least partly explain the therapeutic and other beneficial effects of these compounds including anticarcinogenic and antimutagenic properties. © 1994.
Original languageUndefined/Unknown
Pages (from-to)249-255
Number of pages7
JournalMutation Research
Volume311
Issue number2
DOIs
Publication statusPublished - 1994

Cite this

Subramanian, M., [No Value], S., Devasagayam, T. P. A., & Singh, B. B. (1994). Diminution of singlet oxygen-induced DNA damage by curcmin and related antioxidants. Mutation Research, 311(2), 249-255. https://doi.org/10.1016/0027-5107(94)90183-X
Subramanian, M. ; [No Value], Sreejayan ; Devasagayam, T.P.A. ; Singh, B.B. / Diminution of singlet oxygen-induced DNA damage by curcmin and related antioxidants. In: Mutation Research. 1994 ; Vol. 311, No. 2. pp. 249-255.
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abstract = "Curcumin, the natural antioxidant from turmeric, an Indian spice, and its derivatives have significant abilities to protect plasmid pBR322 against single-strand breaks induced by singlet oxygen (1O2), a reactive oxygen species with potential genotoxic/mutagenic properties. 1O2 was generated at 37°C in an aqueous buffer system by the thermal dissociation of the endoperoxide of 3,3′-(1,4-naphthylene)dipropionate (NDPO2). Among the compounds, tested, curcumin was the most effective inhibitor of DNA damage followed by desmethoxycurcumin, bisdesmethoxycurcumin and other derivatives. The observed antioxidant activity was both time-and concentration-dependent. The protectice ability of curcumin was higher than that of the well-known biological antioxidants lipoate, α-tocopherol and β-carotene. However, the highest protective ability with saturating concentrations of curcumin did not exceed 50{\%}. The ability of curcumin and its derivatives to protect DNA against 1O2 seems to be related to their structures and may at least partly explain the therapeutic and other beneficial effects of these compounds including anticarcinogenic and antimutagenic properties. {\circledC} 1994.",
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Subramanian, M, [No Value], S, Devasagayam, TPA & Singh, BB 1994, 'Diminution of singlet oxygen-induced DNA damage by curcmin and related antioxidants', Mutation Research, vol. 311, no. 2, pp. 249-255. https://doi.org/10.1016/0027-5107(94)90183-X

Diminution of singlet oxygen-induced DNA damage by curcmin and related antioxidants. / Subramanian, M.; [No Value], Sreejayan; Devasagayam, T.P.A.; Singh, B.B.

In: Mutation Research, Vol. 311, No. 2, 1994, p. 249-255.

Research output: Contribution to journalArticle

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T1 - Diminution of singlet oxygen-induced DNA damage by curcmin and related antioxidants

AU - Subramanian, M.

AU - [No Value], Sreejayan

AU - Devasagayam, T.P.A.

AU - Singh, B.B.

N1 - cited By 153

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AB - Curcumin, the natural antioxidant from turmeric, an Indian spice, and its derivatives have significant abilities to protect plasmid pBR322 against single-strand breaks induced by singlet oxygen (1O2), a reactive oxygen species with potential genotoxic/mutagenic properties. 1O2 was generated at 37°C in an aqueous buffer system by the thermal dissociation of the endoperoxide of 3,3′-(1,4-naphthylene)dipropionate (NDPO2). Among the compounds, tested, curcumin was the most effective inhibitor of DNA damage followed by desmethoxycurcumin, bisdesmethoxycurcumin and other derivatives. The observed antioxidant activity was both time-and concentration-dependent. The protectice ability of curcumin was higher than that of the well-known biological antioxidants lipoate, α-tocopherol and β-carotene. However, the highest protective ability with saturating concentrations of curcumin did not exceed 50%. The ability of curcumin and its derivatives to protect DNA against 1O2 seems to be related to their structures and may at least partly explain the therapeutic and other beneficial effects of these compounds including anticarcinogenic and antimutagenic properties. © 1994.

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