TY - JOUR
T1 - Direct-acting antiviral drugs against hepatitis C virus in renal transplant recipients
T2 - Is it the dawn of an interferon-free Era?
AU - Rangaswamy, Dharshan
AU - Nagaraju, Shankar P.
AU - Attur, Ravindra P.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Hepatitis C virus (HCV) is a significant problem among hemodialysis population, especially in India where renal transplant often gets delayed in the presence of live-related donors. An acceleration of liver cirrhosis and poor renal allograft outcomes are often witnessed in allograft recipients with high viral load. Use of interferon in the postrenal transplant setting for the treatment of hepatitis C viral infection was limited to a few grave situations, fearing the precipitation of allograft rejection and poor efficacy for sustained virological remission. However, the availability of newer direct-acting antivirals has opened a new tool box in the management of HCV in the postrenal transplant setting and in reducing the pretransplant waiting period.
AB - Hepatitis C virus (HCV) is a significant problem among hemodialysis population, especially in India where renal transplant often gets delayed in the presence of live-related donors. An acceleration of liver cirrhosis and poor renal allograft outcomes are often witnessed in allograft recipients with high viral load. Use of interferon in the postrenal transplant setting for the treatment of hepatitis C viral infection was limited to a few grave situations, fearing the precipitation of allograft rejection and poor efficacy for sustained virological remission. However, the availability of newer direct-acting antivirals has opened a new tool box in the management of HCV in the postrenal transplant setting and in reducing the pretransplant waiting period.
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U2 - 10.4103/1319-2442.215140
DO - 10.4103/1319-2442.215140
M3 - Article
C2 - 28937081
AN - SCOPUS:85066837758
SN - 1319-2442
VL - 28
SP - 1169
EP - 1174
JO - Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
JF - Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
IS - 5
ER -
