Disseminated Mycobacterium avium intracellulare complex (MAC) disease in a retropositive patient caused by noncompliance of HAART

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Abstract

Mycobacterium avium intracellulare complex (MAC) is the most common mycobacterial cause [after Mycobacterium tuberculosis(MTB)] of an opportunistic disease in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patients with low CD4+ cell count. We report a case of disseminated MAC disease in a 46-year-old retropositive patient, noncompliant to highly active antiretroviral therapy (HAART), with CD4+ T-lymphocyte count of 10 cells/mm3. MAC was isolated in culture from multiple specimens including bone marrow aspirate, blood culture, and bronchoalveolar lavage (BAL) fluid. The patient was successfully treated with the following second-line antitubercular therapies: clarithromycin, rifabutin, and ethambutol.

Original languageEnglish
Pages (from-to)194-196
Number of pages3
JournalAnnals of Tropical Medicine and Public Health
Volume9
Issue number3
DOIs
Publication statusPublished - 01-05-2016

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Mycobacterium avium Complex
Highly Active Antiretroviral Therapy
Patient Compliance
CD4 Lymphocyte Count
Rifabutin
Ethambutol
Clarithromycin
Bronchoalveolar Lavage Fluid
Mycobacterium tuberculosis
Acquired Immunodeficiency Syndrome
Bone Marrow
HIV
T-Lymphocytes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

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title = "Disseminated Mycobacterium avium intracellulare complex (MAC) disease in a retropositive patient caused by noncompliance of HAART",
abstract = "Mycobacterium avium intracellulare complex (MAC) is the most common mycobacterial cause [after Mycobacterium tuberculosis(MTB)] of an opportunistic disease in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patients with low CD4+ cell count. We report a case of disseminated MAC disease in a 46-year-old retropositive patient, noncompliant to highly active antiretroviral therapy (HAART), with CD4+ T-lymphocyte count of 10 cells/mm3. MAC was isolated in culture from multiple specimens including bone marrow aspirate, blood culture, and bronchoalveolar lavage (BAL) fluid. The patient was successfully treated with the following second-line antitubercular therapies: clarithromycin, rifabutin, and ethambutol.",
author = "Kingshuk Dhar and Shenoy, {Vishnu Prasad} and Shashidhar Vishwanath and Mukhyaprana Prabhu",
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AU - Dhar, Kingshuk

AU - Shenoy, Vishnu Prasad

AU - Vishwanath, Shashidhar

AU - Prabhu, Mukhyaprana

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AB - Mycobacterium avium intracellulare complex (MAC) is the most common mycobacterial cause [after Mycobacterium tuberculosis(MTB)] of an opportunistic disease in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patients with low CD4+ cell count. We report a case of disseminated MAC disease in a 46-year-old retropositive patient, noncompliant to highly active antiretroviral therapy (HAART), with CD4+ T-lymphocyte count of 10 cells/mm3. MAC was isolated in culture from multiple specimens including bone marrow aspirate, blood culture, and bronchoalveolar lavage (BAL) fluid. The patient was successfully treated with the following second-line antitubercular therapies: clarithromycin, rifabutin, and ethambutol.

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