Abstract

Valdecoxib is a nonsteroidal antiinflammatory drug, and it is listed in class 2 of biopharmaceutic classification of drugs. Valdecoxib is a poorly water-soluble and highly permeable drug. In the present study a new dissolution medium was developed, as there is no official dissolution medium available in the literature. The composition of the dissolution medium was selected on the basis of solubility data at 37°. Solubility data revealed that addition of surfactant may be suitable as dissolution medium. The concentration of 0.6% w/v sodium lauryl sulphate in water could be a suitable dissolution medium. The discriminating power of the selected dissolution medium (0.6% sodium lauryl sulphate in water) relative to the other dissolution mediums was evaluated. The selected dissolution medium was used for the evaluation of valdecoxib tablets.

Original languageEnglish
Pages (from-to)680-682
Number of pages3
JournalIndian Journal of Pharmaceutical Sciences
Volume68
Issue number5
Publication statusPublished - 01-02-2006

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Tablets
Sodium Dodecyl Sulfate
Solubility
Water
Biopharmaceutics
Pharmaceutical Preparations
Surface-Active Agents
Anti-Inflammatory Agents
valdecoxib

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Subramanian, G., Faisal, M., Karthik, A., Bhat, V., Ranjithkumar, A., & Udupa, N. (2006). Dissolution development of valdecoxib tablets. Indian Journal of Pharmaceutical Sciences, 68(5), 680-682.
Subramanian, G. ; Faisal, M. ; Karthik, A. ; Bhat, V. ; Ranjithkumar, A. ; Udupa, N. / Dissolution development of valdecoxib tablets. In: Indian Journal of Pharmaceutical Sciences. 2006 ; Vol. 68, No. 5. pp. 680-682.
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abstract = "Valdecoxib is a nonsteroidal antiinflammatory drug, and it is listed in class 2 of biopharmaceutic classification of drugs. Valdecoxib is a poorly water-soluble and highly permeable drug. In the present study a new dissolution medium was developed, as there is no official dissolution medium available in the literature. The composition of the dissolution medium was selected on the basis of solubility data at 37°. Solubility data revealed that addition of surfactant may be suitable as dissolution medium. The concentration of 0.6{\%} w/v sodium lauryl sulphate in water could be a suitable dissolution medium. The discriminating power of the selected dissolution medium (0.6{\%} sodium lauryl sulphate in water) relative to the other dissolution mediums was evaluated. The selected dissolution medium was used for the evaluation of valdecoxib tablets.",
author = "G. Subramanian and M. Faisal and A. Karthik and V. Bhat and A. Ranjithkumar and N. Udupa",
note = "Cited By :2 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Udupa, N.; Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104, India; email: n.udupa@manipal.edu Chemicals/CAS: dodecyl sulfate sodium, 151-21-3; polysorbate 80, 8050-83-7, 9005-65-6; valdecoxib, 181695-72-7; water, 7732-18-5 Tradenames: revaldo 20, Bangalore, India; valus, Glenmark, India Manufacturers: Bangalore, India; Glenmark, India; IPCA, India; Qualigens, India References: Kurumbali, R.G., Stevens, A.M., Gierse, J.K., McDonald, J.J., Stegman, R.A., Pak, J.Y., Gildehaus, D., Stalling, W.C., (1996) Nature, 384, p. 644; Peterson, W.L., Cryer, B., (1999) J. Amer. Med. Assn, 282, p. 1961; Gander, B., Ventourase, K., Gurny, R., Doelkar, E., (1985) Int. J. Pharm, 27, p. 117; Gibladi, M., Feldman, S., (1967) J. Pharm. Sci, 56, p. 1238; Shah, V.P., Konecny, J.J., Everett, R.L., McCullough, B., Skelly, J.P., (1989) Pharm. Res, 6, p. 612; United States of Pharmacopoeia 23, US Pharmacopoeia Convention, 1995, 267; Abdou, H.M., Hanna, S., Mohammad, N., (2000) Remington: The Science and Practice of Pharmacy, 1, p. 655. , Gennaro, A.R, Eds, 20th Edn, Lippncott Williams and Wilkins, Baltimore, Maryland; Schott, H., Kwan, L.C., Feldman, S., (1982) J. Pharm. Sci, 71, p. 1038; Babu, M.M.G.V., Shankar, G.V., Shankar, H.K., Seshayana, A., Kumar, K.N., Murthy, R.K.V., (2002) Indian J. Pharm. Sci, p. 588",
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Subramanian, G, Faisal, M, Karthik, A, Bhat, V, Ranjithkumar, A & Udupa, N 2006, 'Dissolution development of valdecoxib tablets', Indian Journal of Pharmaceutical Sciences, vol. 68, no. 5, pp. 680-682.

Dissolution development of valdecoxib tablets. / Subramanian, G.; Faisal, M.; Karthik, A.; Bhat, V.; Ranjithkumar, A.; Udupa, N.

In: Indian Journal of Pharmaceutical Sciences, Vol. 68, No. 5, 01.02.2006, p. 680-682.

Research output: Contribution to journalArticle

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N2 - Valdecoxib is a nonsteroidal antiinflammatory drug, and it is listed in class 2 of biopharmaceutic classification of drugs. Valdecoxib is a poorly water-soluble and highly permeable drug. In the present study a new dissolution medium was developed, as there is no official dissolution medium available in the literature. The composition of the dissolution medium was selected on the basis of solubility data at 37°. Solubility data revealed that addition of surfactant may be suitable as dissolution medium. The concentration of 0.6% w/v sodium lauryl sulphate in water could be a suitable dissolution medium. The discriminating power of the selected dissolution medium (0.6% sodium lauryl sulphate in water) relative to the other dissolution mediums was evaluated. The selected dissolution medium was used for the evaluation of valdecoxib tablets.

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Subramanian G, Faisal M, Karthik A, Bhat V, Ranjithkumar A, Udupa N. Dissolution development of valdecoxib tablets. Indian Journal of Pharmaceutical Sciences. 2006 Feb 1;68(5):680-682.