Distribution of HLA class II antigen in renal transplant patients and donors visiting tertiary care hospital of Karnataka state in South India

Murali Adiga, Kirtana Pai, M. G.Ramesh Babu, Sivakumar

Research output: Contribution to journalArticle

Abstract

Renal transplantation is the most successful treatment option for chronic renal failure patients. But success of any transplantation depends on HLA antigen matching between the recipient and the donor. This study is the first report from Karnataka state of South India to find out distribution of HLA-class II antigens in live renal transplant recipients and donors visiting a tertiary care hospital. In this study, HLA-DR allele frequencies were studied in 314 renal transplant recipients and donors visited our hospital, during 2005–2013. HLA tissue typing was done by polymerase chain reaction using sequence specific primers. Then antigen frequencies were obtained and analyzed. A total of 32 HLA-DRB1 alleles were identified in the renal transplant recipients and donors. High frequency DRB1 alleles found in our patients and donors were DRB1 ∗ 15(25.4%), DRB1 ∗ 14(12.2%), DRB1∗ 04(11.3%), DRB1∗ 13(10.2%), DRB1∗ 07(8.3%). DRB1∗ 15 allele was the most frequent DRB1 antigen in both males and females. Also we have found that females outnumbered males among the donors. The results showed significant heterogeneity in HLA-DRB1 alleles. The most frequent HLA-DRB3, DRB4, DRB5 alleles we observed are DRB3∗ 01/02, DRB4∗ 01, DRB5∗ 01/02 respectively.

Original languageEnglish
Pages (from-to)1885-1888
Number of pages4
JournalAdvanced Science Letters
Volume23
Issue number3
DOIs
Publication statusPublished - 01-03-2017

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Transplants
Transplantation
Histocompatibility Antigens Class II
India
Tertiary Healthcare
Antigens
HLA Antigens
antigen
Tertiary Care Centers
allele
recipient
Tissue Donors
Kidney
Polymerase Chain Reaction
Alleles
HLA-DRB1 Chains
Histocompatibility Testing
transplantation
Gene Frequency
HLA-DRB4 Chains

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Computer Science(all)
  • Education
  • Mathematics(all)
  • Environmental Science(all)
  • Engineering(all)
  • Energy(all)

Cite this

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abstract = "Renal transplantation is the most successful treatment option for chronic renal failure patients. But success of any transplantation depends on HLA antigen matching between the recipient and the donor. This study is the first report from Karnataka state of South India to find out distribution of HLA-class II antigens in live renal transplant recipients and donors visiting a tertiary care hospital. In this study, HLA-DR allele frequencies were studied in 314 renal transplant recipients and donors visited our hospital, during 2005–2013. HLA tissue typing was done by polymerase chain reaction using sequence specific primers. Then antigen frequencies were obtained and analyzed. A total of 32 HLA-DRB1 alleles were identified in the renal transplant recipients and donors. High frequency DRB1 alleles found in our patients and donors were DRB1 ∗ 15(25.4{\%}), DRB1 ∗ 14(12.2{\%}), DRB1∗ 04(11.3{\%}), DRB1∗ 13(10.2{\%}), DRB1∗ 07(8.3{\%}). DRB1∗ 15 allele was the most frequent DRB1 antigen in both males and females. Also we have found that females outnumbered males among the donors. The results showed significant heterogeneity in HLA-DRB1 alleles. The most frequent HLA-DRB3, DRB4, DRB5 alleles we observed are DRB3∗ 01/02, DRB4∗ 01, DRB5∗ 01/02 respectively.",
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Distribution of HLA class II antigen in renal transplant patients and donors visiting tertiary care hospital of Karnataka state in South India. / Adiga, Murali; Pai, Kirtana; Babu, M. G.Ramesh; Sivakumar.

In: Advanced Science Letters, Vol. 23, No. 3, 01.03.2017, p. 1885-1888.

Research output: Contribution to journalArticle

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