Diverse clinical spectrum of stress-induced cardiomyopathy

Yian Ping Lee, Kian Keong Poh, Chi Hang Lee, Huay Cheem Tan, Abdul Razak, Boon Lock Chia, Adrian F. Low

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Stress-induced cardiomyopathy or Takotsubo cardiomyopathy is an uncommon disorder characterized by apical ballooning. The etiology and pathophysiology of this syndrome has not been fully evaluated. This case series examined the clinical characteristics and outcomes of 10 patients with confirmed stress-induced cardiomyopathy. We identified 10 cases of stress-induced cardiomyopathy. All exhibit characteristic apical ballooning and basal hyperkinesia except one with an "inverted Takotsubo" pattern. Coronary angiography excluded coronary artery stenoses as a cause of cardiomyopathy. Patient characteristics, cardiac function, follow-up echocardiography and outcomes were determined. 60% of cases were female and 70% of cases had ST-segment elevations. Identified precipitants included severe emotional stress, subarachnoid haemorrhage and sepsis. None of the cases had angiographically significant coronary stenosis. One patient had an "inverted Takotsubo" pattern with mid-ventricular ballooning. Stress-induced cardiomyopathy is a clinical spectrum which can present with a classical "Takotsubo" or "inverted Takotsubo" pattern. Presentation is varied but characterized by recovery to normal cardiac systolic function. Study of this syndrome may enhance further understanding of the "brain-heart" relationship.

Original languageEnglish
Pages (from-to)272-275
Number of pages4
JournalInternational Journal of Cardiology
Volume133
Issue number2
DOIs
Publication statusPublished - 03-04-2009

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Takotsubo Cardiomyopathy
Coronary Stenosis
Hyperkinesis
Subarachnoid Hemorrhage
Coronary Angiography
Cardiomyopathies
Psychological Stress
Echocardiography
Sepsis
Brain

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Lee, Y. P., Poh, K. K., Lee, C. H., Tan, H. C., Razak, A., Chia, B. L., & Low, A. F. (2009). Diverse clinical spectrum of stress-induced cardiomyopathy. International Journal of Cardiology, 133(2), 272-275. https://doi.org/10.1016/j.ijcard.2007.11.039
Lee, Yian Ping ; Poh, Kian Keong ; Lee, Chi Hang ; Tan, Huay Cheem ; Razak, Abdul ; Chia, Boon Lock ; Low, Adrian F. / Diverse clinical spectrum of stress-induced cardiomyopathy. In: International Journal of Cardiology. 2009 ; Vol. 133, No. 2. pp. 272-275.
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Diverse clinical spectrum of stress-induced cardiomyopathy. / Lee, Yian Ping; Poh, Kian Keong; Lee, Chi Hang; Tan, Huay Cheem; Razak, Abdul; Chia, Boon Lock; Low, Adrian F.

In: International Journal of Cardiology, Vol. 133, No. 2, 03.04.2009, p. 272-275.

Research output: Contribution to journalArticle

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