DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics

Dipanjan Bhattacharjee, Smita Shenoy, Kurady Laxminarayana Bairy

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Epigenetics deals with the interactions between genes and the immediate cellular environment. These interactions go a long way in shaping up each and every person's individuality. Further, reversibility of epigenetic interactions may offer a dynamic control over the expression of various critical genes. Thus, tweaking the epigenetic machinery may help cause or cure diseases, especially cancer. Therefore, cancer epigenetics, especially at a molecular level, needs to be scrutinised closely, as it could potentially serve as the future pharmaceutical goldmine against neoplastic diseases. However, in view of its rapidly enlarging scope of application, it has become difficult to keep abreast of scientific information coming out of various epigenetic studies directed against cancer. Using this review, we have attempted to shed light on two of the most important mechanisms implicated in cancer, that is, DNA (deoxyribonucleic acid) methylation and histone modifications, and their place in cancer pathogenesis. Further, we have attempted to take stock of the new epigenetic drugs that have emerged onto the market as well as those in the pipeline that offer hope in mankind's fight against cancer.

Original languageEnglish
Article number6072357
JournalScientifica
Volume2016
DOIs
Publication statusPublished - 01-01-2016

Fingerprint

Chromatin Assembly and Disassembly
methylation
Epigenomics
epigenetics
Methylation
chromatin
cancer
DNA
neoplasms
Neoplasms
Hope
drug
Histone Code
drugs
gene
histones
Individuality
Pharmaceutical Preparations
machinery
Genes

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Bhattacharjee, Dipanjan ; Shenoy, Smita ; Bairy, Kurady Laxminarayana. / DNA Methylation and Chromatin Remodeling : The Blueprint of Cancer Epigenetics. In: Scientifica. 2016 ; Vol. 2016.
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DNA Methylation and Chromatin Remodeling : The Blueprint of Cancer Epigenetics. / Bhattacharjee, Dipanjan; Shenoy, Smita; Bairy, Kurady Laxminarayana.

In: Scientifica, Vol. 2016, 6072357, 01.01.2016.

Research output: Contribution to journalReview article

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