Abstract

Background: DOC2B promoter hypermethylation is an early and frequent event in cervical cancer. Results: DOC2B hypermethylation induces transcriptional repression, reactivated by demethylation; ectopic expression increases Ca 2+ flux and inhibits key characteristics of tumorigenesis including proliferation, motility, and invasion. Conclusion: DOC2B gene is epigenetically regulated and inhibits cervical cancer growth. Significance: DNA methylation regulates DOC2B gene expression in cervical cancer.

Original languageEnglish
Pages (from-to)10637-10649
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number15
DOIs
Publication statusPublished - 11-04-2014

Fingerprint

DNA Methylation
Transcription
Gene expression
Uterine Cervical Neoplasms
Tumors
Genes
Fluxes
Growth
Neoplasms
Carcinogenesis
Gene Expression
C2 Domains

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

@article{2e155abea3994607aa7d9da0342e675f,
title = "DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer",
abstract = "Background: DOC2B promoter hypermethylation is an early and frequent event in cervical cancer. Results: DOC2B hypermethylation induces transcriptional repression, reactivated by demethylation; ectopic expression increases Ca 2+ flux and inhibits key characteristics of tumorigenesis including proliferation, motility, and invasion. Conclusion: DOC2B gene is epigenetically regulated and inhibits cervical cancer growth. Significance: DNA methylation regulates DOC2B gene expression in cervical cancer.",
author = "Kabekkodu, {Shama Prasada} and Samatha Bhat and Raghu Radhakrishnan and Abhijit Aithal and Roshan Mascarenhas and Deeksha Pandey and Lavanya Rai and Pralhad Kushtagi and Mundyat, {Gopinath Puthiya} and Kapaettu Satyamoorthy",
year = "2014",
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day = "11",
doi = "10.1074/jbc.M113.491506",
language = "English",
volume = "289",
pages = "10637--10649",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "15",

}

DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer. / Kabekkodu, Shama Prasada; Bhat, Samatha; Radhakrishnan, Raghu; Aithal, Abhijit; Mascarenhas, Roshan; Pandey, Deeksha; Rai, Lavanya; Kushtagi, Pralhad; Mundyat, Gopinath Puthiya; Satyamoorthy, Kapaettu.

In: Journal of Biological Chemistry, Vol. 289, No. 15, 11.04.2014, p. 10637-10649.

Research output: Contribution to journalArticle

TY - JOUR

T1 - DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer

AU - Kabekkodu, Shama Prasada

AU - Bhat, Samatha

AU - Radhakrishnan, Raghu

AU - Aithal, Abhijit

AU - Mascarenhas, Roshan

AU - Pandey, Deeksha

AU - Rai, Lavanya

AU - Kushtagi, Pralhad

AU - Mundyat, Gopinath Puthiya

AU - Satyamoorthy, Kapaettu

PY - 2014/4/11

Y1 - 2014/4/11

N2 - Background: DOC2B promoter hypermethylation is an early and frequent event in cervical cancer. Results: DOC2B hypermethylation induces transcriptional repression, reactivated by demethylation; ectopic expression increases Ca 2+ flux and inhibits key characteristics of tumorigenesis including proliferation, motility, and invasion. Conclusion: DOC2B gene is epigenetically regulated and inhibits cervical cancer growth. Significance: DNA methylation regulates DOC2B gene expression in cervical cancer.

AB - Background: DOC2B promoter hypermethylation is an early and frequent event in cervical cancer. Results: DOC2B hypermethylation induces transcriptional repression, reactivated by demethylation; ectopic expression increases Ca 2+ flux and inhibits key characteristics of tumorigenesis including proliferation, motility, and invasion. Conclusion: DOC2B gene is epigenetically regulated and inhibits cervical cancer growth. Significance: DNA methylation regulates DOC2B gene expression in cervical cancer.

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