TY - JOUR
T1 - DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer
AU - Kabekkodu, Shama Prasada
AU - Bhat, Samatha
AU - Radhakrishnan, Raghu
AU - Aithal, Abhijit
AU - Mascarenhas, Roshan
AU - Pandey, Deeksha
AU - Rai, Lavanya
AU - Kushtagi, Pralhad
AU - Mundyat, Gopinath Puthiya
AU - Satyamoorthy, Kapaettu
PY - 2014/4/11
Y1 - 2014/4/11
N2 - Background: DOC2B promoter hypermethylation is an early and frequent event in cervical cancer. Results: DOC2B hypermethylation induces transcriptional repression, reactivated by demethylation; ectopic expression increases Ca 2+ flux and inhibits key characteristics of tumorigenesis including proliferation, motility, and invasion. Conclusion: DOC2B gene is epigenetically regulated and inhibits cervical cancer growth. Significance: DNA methylation regulates DOC2B gene expression in cervical cancer.
AB - Background: DOC2B promoter hypermethylation is an early and frequent event in cervical cancer. Results: DOC2B hypermethylation induces transcriptional repression, reactivated by demethylation; ectopic expression increases Ca 2+ flux and inhibits key characteristics of tumorigenesis including proliferation, motility, and invasion. Conclusion: DOC2B gene is epigenetically regulated and inhibits cervical cancer growth. Significance: DNA methylation regulates DOC2B gene expression in cervical cancer.
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U2 - 10.1074/jbc.M113.491506
DO - 10.1074/jbc.M113.491506
M3 - Article
C2 - 24570007
AN - SCOPUS:84898670676
SN - 0021-9258
VL - 289
SP - 10637
EP - 10649
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 15
ER -
