Does serum Vitamin D status influence high-sensitivity c-reactive protein and gensini score in established coronary artery disease individuals

A. P. Shaheena, Poornima A. Manjrekar, Vivian D'souza, Padmanabh Kamath, M. S. Rukmini, Vinod Chandran, Durgarao Yalla, Mukund P. Srinivasan

Research output: Contribution to journalArticle

Abstract

Introduction: Over the years, the extraskeletal effects of Vitamin D (vit D) are gaining prominence. The role of vit D deficiency (VDD) in coronary artery disease (CAD) is conflicting. Hence, the present study was aimed to correlate serum vit D levels with high-sensitivity C-reactive protein (hs-CRP) and Gensini score in CAD individuals. Materials and Methods: This cross-sectional study was conducted on 70 angiographically proven CAD individuals aged between 35 and 55 years of both sexes who presented with a history of myocardial injury or ischemia for the first time. The angiographic findings were graded using Gensini score. Serum vit D and hs-CRP were estimated using enzyme-linked immunosorbent assay. Results: The average serum vit D level was 15 ng/mL, and the ratio of diabetes and nondiabetes individuals was 52:18. Among the 70 patients, 66% (n = 46) were deficient, 20% (n = 14) were insufficient, and 14% (n = 10) had normal vit D status. Although insignificant, vit D levels had negative correlation with Gensini score (r = -0.17, P = 0.14) and hs-CRP levels (r = -0.03, P = 0.77) which was not sustained after multivariate logistic regression. A significant negative correlation (r = -0.35, P = 0.01) was found between serum vit D status and duration of diabetes. Conclusion: VDD observed in diabetes individuals is inversely related to the duration of diabetes which incidentally is associated with CAD. Thus, screening for vit D status may be vital for the management of CAD particularly in diabetes individuals.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalJournal of Natural Science, Biology and Medicine
Volume10
Issue number2
DOIs
Publication statusPublished - 01-07-2019

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Vitamin D
Coronary Artery Disease
Medical problems
Serum
Proteins
C-Reactive Protein
Vitamin D Deficiency
Immunosorbents
Ischemia
Logistics
Cross-Sectional Studies
Logistic Models
Enzyme-Linked Immunosorbent Assay
Assays
Screening
Wounds and Injuries
Enzymes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Does serum Vitamin D status influence high-sensitivity c-reactive protein and gensini score in established coronary artery disease individuals",
abstract = "Introduction: Over the years, the extraskeletal effects of Vitamin D (vit D) are gaining prominence. The role of vit D deficiency (VDD) in coronary artery disease (CAD) is conflicting. Hence, the present study was aimed to correlate serum vit D levels with high-sensitivity C-reactive protein (hs-CRP) and Gensini score in CAD individuals. Materials and Methods: This cross-sectional study was conducted on 70 angiographically proven CAD individuals aged between 35 and 55 years of both sexes who presented with a history of myocardial injury or ischemia for the first time. The angiographic findings were graded using Gensini score. Serum vit D and hs-CRP were estimated using enzyme-linked immunosorbent assay. Results: The average serum vit D level was 15 ng/mL, and the ratio of diabetes and nondiabetes individuals was 52:18. Among the 70 patients, 66{\%} (n = 46) were deficient, 20{\%} (n = 14) were insufficient, and 14{\%} (n = 10) had normal vit D status. Although insignificant, vit D levels had negative correlation with Gensini score (r = -0.17, P = 0.14) and hs-CRP levels (r = -0.03, P = 0.77) which was not sustained after multivariate logistic regression. A significant negative correlation (r = -0.35, P = 0.01) was found between serum vit D status and duration of diabetes. Conclusion: VDD observed in diabetes individuals is inversely related to the duration of diabetes which incidentally is associated with CAD. Thus, screening for vit D status may be vital for the management of CAD particularly in diabetes individuals.",
author = "Shaheena, {A. P.} and Manjrekar, {Poornima A.} and Vivian D'souza and Padmanabh Kamath and Rukmini, {M. S.} and Vinod Chandran and Durgarao Yalla and Srinivasan, {Mukund P.}",
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Does serum Vitamin D status influence high-sensitivity c-reactive protein and gensini score in established coronary artery disease individuals. / Shaheena, A. P.; Manjrekar, Poornima A.; D'souza, Vivian; Kamath, Padmanabh; Rukmini, M. S.; Chandran, Vinod; Yalla, Durgarao; Srinivasan, Mukund P.

In: Journal of Natural Science, Biology and Medicine, Vol. 10, No. 2, 01.07.2019, p. 197-201.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Does serum Vitamin D status influence high-sensitivity c-reactive protein and gensini score in established coronary artery disease individuals

AU - Shaheena, A. P.

AU - Manjrekar, Poornima A.

AU - D'souza, Vivian

AU - Kamath, Padmanabh

AU - Rukmini, M. S.

AU - Chandran, Vinod

AU - Yalla, Durgarao

AU - Srinivasan, Mukund P.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Introduction: Over the years, the extraskeletal effects of Vitamin D (vit D) are gaining prominence. The role of vit D deficiency (VDD) in coronary artery disease (CAD) is conflicting. Hence, the present study was aimed to correlate serum vit D levels with high-sensitivity C-reactive protein (hs-CRP) and Gensini score in CAD individuals. Materials and Methods: This cross-sectional study was conducted on 70 angiographically proven CAD individuals aged between 35 and 55 years of both sexes who presented with a history of myocardial injury or ischemia for the first time. The angiographic findings were graded using Gensini score. Serum vit D and hs-CRP were estimated using enzyme-linked immunosorbent assay. Results: The average serum vit D level was 15 ng/mL, and the ratio of diabetes and nondiabetes individuals was 52:18. Among the 70 patients, 66% (n = 46) were deficient, 20% (n = 14) were insufficient, and 14% (n = 10) had normal vit D status. Although insignificant, vit D levels had negative correlation with Gensini score (r = -0.17, P = 0.14) and hs-CRP levels (r = -0.03, P = 0.77) which was not sustained after multivariate logistic regression. A significant negative correlation (r = -0.35, P = 0.01) was found between serum vit D status and duration of diabetes. Conclusion: VDD observed in diabetes individuals is inversely related to the duration of diabetes which incidentally is associated with CAD. Thus, screening for vit D status may be vital for the management of CAD particularly in diabetes individuals.

AB - Introduction: Over the years, the extraskeletal effects of Vitamin D (vit D) are gaining prominence. The role of vit D deficiency (VDD) in coronary artery disease (CAD) is conflicting. Hence, the present study was aimed to correlate serum vit D levels with high-sensitivity C-reactive protein (hs-CRP) and Gensini score in CAD individuals. Materials and Methods: This cross-sectional study was conducted on 70 angiographically proven CAD individuals aged between 35 and 55 years of both sexes who presented with a history of myocardial injury or ischemia for the first time. The angiographic findings were graded using Gensini score. Serum vit D and hs-CRP were estimated using enzyme-linked immunosorbent assay. Results: The average serum vit D level was 15 ng/mL, and the ratio of diabetes and nondiabetes individuals was 52:18. Among the 70 patients, 66% (n = 46) were deficient, 20% (n = 14) were insufficient, and 14% (n = 10) had normal vit D status. Although insignificant, vit D levels had negative correlation with Gensini score (r = -0.17, P = 0.14) and hs-CRP levels (r = -0.03, P = 0.77) which was not sustained after multivariate logistic regression. A significant negative correlation (r = -0.35, P = 0.01) was found between serum vit D status and duration of diabetes. Conclusion: VDD observed in diabetes individuals is inversely related to the duration of diabetes which incidentally is associated with CAD. Thus, screening for vit D status may be vital for the management of CAD particularly in diabetes individuals.

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