Does the glycated hemoglobin have an impact on atherogenic cholesterol in type 2 diabetes patients?

R. N. Devaki, B. K. Manjunatha Goud, Oinam Sarsina Devi, K. Deepa, Bhavna Nayal, Asha Prabhu, Naureen Anwar

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Abstract

Diabetes mellitus is a group of metabolic disease characterized by hyperglycemia resulting from defective insulin secretion, insulin action or both. Studies on chronic complications of diabetes established the role of glycosylated hemoglobin (HbA1c) as a marker of evaluation of long term glycemic control and risk for chronic complications. This is a cross sectional study carried out on 40 diabetic patients and 50 normal individuals, between the age group of 40-60 years attending medicine OPD were included as study subjects. Diabetes was diagonsed based on laboratory and clinincal co-relation. 5ml of fasting venous sample was taken from study sujects and following parameters were estimated LDL, FPG and glycatedhemoglobin. The values of HbA1c and FPG were statistically significant in diabetic subjects when compared to controls (p< 0.001). The levels of LDL-C were increased in diabetic subjects but were not statistically significant. In conclusion, significant co-relation between HbA1c and LDL-C levels can be used as a potential biomarker for predicting dyslipidemia in type 2 diabetic patients in addition to long term glycemic control.

Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume3
Issue number1
Publication statusPublished - 01-01-2012

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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