Dose-dependent increase in the frequency of micronuclei and chromosomal aberrations by misonidazole in mouse bone marrow

Kheem Singh Bisht, Pathirissery Uma Devi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cytogenetic effects produced in bone marrow of mice by various doses of misonidazole (MISO, 100 to 1000 mg/kg bodyweight) were studied by assaying the induction of micronuclei (MN) and chromosomal aberrations. Misonidazole increased the frequency of both micronuclei and chromosomal aberrations over normal at 24 h after treatment, however, the values were statistically significant from normal only at drug doses above 250 mg/kg. The increase was proportional to the drug dose with a best fit to linear quadratic model for MN induction. For chromosomal aberrations the data fitted eqully well to linear as well as linear quadratic models.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalMutation Research Letters
Volume325
Issue number2-3
DOIs
Publication statusPublished - 01-01-1994
Externally publishedYes

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Misonidazole
Chromosome Aberrations
Bone Marrow
Linear Models
Cytogenetics
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Cytogenetic effects produced in bone marrow of mice by various doses of misonidazole (MISO, 100 to 1000 mg/kg bodyweight) were studied by assaying the induction of micronuclei (MN) and chromosomal aberrations. Misonidazole increased the frequency of both micronuclei and chromosomal aberrations over normal at 24 h after treatment, however, the values were statistically significant from normal only at drug doses above 250 mg/kg. The increase was proportional to the drug dose with a best fit to linear quadratic model for MN induction. For chromosomal aberrations the data fitted eqully well to linear as well as linear quadratic models.",
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Dose-dependent increase in the frequency of micronuclei and chromosomal aberrations by misonidazole in mouse bone marrow. / Bisht, Kheem Singh; Uma Devi, Pathirissery.

In: Mutation Research Letters, Vol. 325, No. 2-3, 01.01.1994, p. 57-63.

Research output: Contribution to journalArticle

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