Drug induced hepatitis with anti-tubercular chemotherapy: Challenges and difficulties in treatment

P. V. Kishore, S. Palaian, R. Paudel, P. Mishra, M. Prabhu, P. R. Shankar

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Tuberculosis is a major health burden worldwide. In Nepal, it is a significant cause of morbidity and mortality. Although better drugs are available for managing tuberculosis, treatment failure is one of the common problems encountered. Among the various causes which can cause treatment interruption, drug induced hepatotoxicity is a common cause. Isoniazid and Pyrazinamide are the common drugs causing hepatotoxicity. Upon occurrence of hepatotoxicity, the hepatotoxic drugs should be stopped and reintroduced as per the available guidelines. The healthcare professional should also counsel the patients for recognizing the early symptoms due to hepatotoxicity which could prevent morbidity.

Original languageEnglish
Pages (from-to)256-260
Number of pages5
JournalKathmandu University Medical Journal
Volume5
Issue number18
Publication statusPublished - 01-12-2007

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kishore, P. V., Palaian, S., Paudel, R., Mishra, P., Prabhu, M., & Shankar, P. R. (2007). Drug induced hepatitis with anti-tubercular chemotherapy: Challenges and difficulties in treatment. Kathmandu University Medical Journal, 5(18), 256-260.