Drug utilization evaluation of third generation cephalosporins in a tertiary care hospital in South India

B. Jimmy, G. Parthasarthi, J. Jose

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The purpose of the study was to evaluate the prescribing pattern of third generation cephalosporins in a tertiary care hospital and develop guidelines for its use. Antibiotic utilization evaluation of third generation cephalosporins was carried out over a period of eight months in medicine and pediatric wards by evaluation of patient case notes. A guideline for the use of third generation cephalosporins was prepared by the method of formal consensus and was implemented in the hospital. Appropriateness of use of third generation cephalosporins before and after implementation of guidelines was assessed in terms of indication for use, dose, frequency of administration, duration of therapy and change over from intravenous route to oral therapy with regard to the prepared guidelines. A total of 200 prescriptions containing third generation cephalosporins were reviewed and assessed for appropriateness, of which 100 each were before and after implementation of the guidelines. Ceftriaxone was the most commonly prescribed cephalosporin and enteric fever the most common indication for which is used in the pre and post implementation phase. The overall appropriateness of use of third generation cephalosporins before implementation of the guidelines was 91% for indication, 77% for dose,100% for frequency of administration, 81% for duration of therapy and 81% for change over from intravenous route to oral therapy. After implementation of guidelines, an improvement in appropriateness was seen for the various parameters such as indication (93%), dose (94%), duration of therapy (90%), change over from intravenous route to oral therapy (86%). This study shows that drug utilization evaluation programs and clinical practice guidelines does have the potential for making a positive contribution to health care by promoting effective use of drugs. © APTI.
Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalIndian Journal of Pharmaceutical Education and Research
Volume42
Issue number3
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Drug Utilization Review
Tertiary Healthcare
Cephalosporins
Tertiary Care Centers
India
Guidelines
Therapeutics
Ceftriaxone
Typhoid Fever
Practice Guidelines
Prescriptions
Medicine
Pediatrics
Anti-Bacterial Agents
Delivery of Health Care

Cite this

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title = "Drug utilization evaluation of third generation cephalosporins in a tertiary care hospital in South India",
abstract = "The purpose of the study was to evaluate the prescribing pattern of third generation cephalosporins in a tertiary care hospital and develop guidelines for its use. Antibiotic utilization evaluation of third generation cephalosporins was carried out over a period of eight months in medicine and pediatric wards by evaluation of patient case notes. A guideline for the use of third generation cephalosporins was prepared by the method of formal consensus and was implemented in the hospital. Appropriateness of use of third generation cephalosporins before and after implementation of guidelines was assessed in terms of indication for use, dose, frequency of administration, duration of therapy and change over from intravenous route to oral therapy with regard to the prepared guidelines. A total of 200 prescriptions containing third generation cephalosporins were reviewed and assessed for appropriateness, of which 100 each were before and after implementation of the guidelines. Ceftriaxone was the most commonly prescribed cephalosporin and enteric fever the most common indication for which is used in the pre and post implementation phase. The overall appropriateness of use of third generation cephalosporins before implementation of the guidelines was 91{\%} for indication, 77{\%} for dose,100{\%} for frequency of administration, 81{\%} for duration of therapy and 81{\%} for change over from intravenous route to oral therapy. After implementation of guidelines, an improvement in appropriateness was seen for the various parameters such as indication (93{\%}), dose (94{\%}), duration of therapy (90{\%}), change over from intravenous route to oral therapy (86{\%}). This study shows that drug utilization evaluation programs and clinical practice guidelines does have the potential for making a positive contribution to health care by promoting effective use of drugs. {\circledC} APTI.",
author = "B. Jimmy and G. Parthasarthi and J. Jose",
note = "Cited By :1 Export Date: 10 November 2017 Correspondence Address: Jimmy, B.; Department of Pharmacy Practice, Manipal College of Pharmaceutical sciences, Manipal-576104, India; email: binageorge1@yahoo.co.in Chemicals/CAS: cefixime, 79350-37-1; cefoperazone, 62893-19-0, 62893-20-3; cefotaxime, 63527-52-6, 64485-93-4; ceftazidime, 72558-82-8; ceftriaxone, 73384-59-5, 74578-69-1 References: Report calls for action on antibiotic resistance (1998) BMJ, 316, p. 1261. , Kamran Abbasi; Lindbaek, M., Berild, D., Straand, J., Hjortdahl, P., Influence of prescription patterns in general practice on anti-microbial resistance in Norway (1999) Br J Gen Pract, 49 (443), pp. 436-440; Hart, C.A., Antibiotic resistance: An increasing problem? (1998) BMJ, 316 (7140), pp. 1255-1256; Gary, M.H., Missan, H., The members of Society of Hospital Pharmacists of Australia (1998) SHPA Standards of Practice For Drug Usage Evaluation In Australian Hospitals, 2 (15), pp. 1-15. , Australia, 7; O'Hanley, P., Rodondi, L., Coleman, R., Efficacy and cost-effectiveness of antibiotic monitoring at a Veterans Administration Hospital (1991) Chemotherapy, 37, pp. 22-25; Lemire, M., Wing, L., Gardon, D.L., An audit of third generation cephalosporin prescribing in a tertiary care hospital (1996) Aust NZ J Med, 26, pp. 386-390",
year = "2008",
language = "English",
volume = "42",
pages = "295--300",
journal = "Indian Journal of Pharmaceutical Education and Research",
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Drug utilization evaluation of third generation cephalosporins in a tertiary care hospital in South India. / Jimmy, B.; Parthasarthi, G.; Jose, J.

In: Indian Journal of Pharmaceutical Education and Research, Vol. 42, No. 3, 2008, p. 295-300.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Drug utilization evaluation of third generation cephalosporins in a tertiary care hospital in South India

AU - Jimmy, B.

AU - Parthasarthi, G.

AU - Jose, J.

N1 - Cited By :1 Export Date: 10 November 2017 Correspondence Address: Jimmy, B.; Department of Pharmacy Practice, Manipal College of Pharmaceutical sciences, Manipal-576104, India; email: binageorge1@yahoo.co.in Chemicals/CAS: cefixime, 79350-37-1; cefoperazone, 62893-19-0, 62893-20-3; cefotaxime, 63527-52-6, 64485-93-4; ceftazidime, 72558-82-8; ceftriaxone, 73384-59-5, 74578-69-1 References: Report calls for action on antibiotic resistance (1998) BMJ, 316, p. 1261. , Kamran Abbasi; Lindbaek, M., Berild, D., Straand, J., Hjortdahl, P., Influence of prescription patterns in general practice on anti-microbial resistance in Norway (1999) Br J Gen Pract, 49 (443), pp. 436-440; Hart, C.A., Antibiotic resistance: An increasing problem? (1998) BMJ, 316 (7140), pp. 1255-1256; Gary, M.H., Missan, H., The members of Society of Hospital Pharmacists of Australia (1998) SHPA Standards of Practice For Drug Usage Evaluation In Australian Hospitals, 2 (15), pp. 1-15. , Australia, 7; O'Hanley, P., Rodondi, L., Coleman, R., Efficacy and cost-effectiveness of antibiotic monitoring at a Veterans Administration Hospital (1991) Chemotherapy, 37, pp. 22-25; Lemire, M., Wing, L., Gardon, D.L., An audit of third generation cephalosporin prescribing in a tertiary care hospital (1996) Aust NZ J Med, 26, pp. 386-390

PY - 2008

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N2 - The purpose of the study was to evaluate the prescribing pattern of third generation cephalosporins in a tertiary care hospital and develop guidelines for its use. Antibiotic utilization evaluation of third generation cephalosporins was carried out over a period of eight months in medicine and pediatric wards by evaluation of patient case notes. A guideline for the use of third generation cephalosporins was prepared by the method of formal consensus and was implemented in the hospital. Appropriateness of use of third generation cephalosporins before and after implementation of guidelines was assessed in terms of indication for use, dose, frequency of administration, duration of therapy and change over from intravenous route to oral therapy with regard to the prepared guidelines. A total of 200 prescriptions containing third generation cephalosporins were reviewed and assessed for appropriateness, of which 100 each were before and after implementation of the guidelines. Ceftriaxone was the most commonly prescribed cephalosporin and enteric fever the most common indication for which is used in the pre and post implementation phase. The overall appropriateness of use of third generation cephalosporins before implementation of the guidelines was 91% for indication, 77% for dose,100% for frequency of administration, 81% for duration of therapy and 81% for change over from intravenous route to oral therapy. After implementation of guidelines, an improvement in appropriateness was seen for the various parameters such as indication (93%), dose (94%), duration of therapy (90%), change over from intravenous route to oral therapy (86%). This study shows that drug utilization evaluation programs and clinical practice guidelines does have the potential for making a positive contribution to health care by promoting effective use of drugs. © APTI.

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M3 - Article

VL - 42

SP - 295

EP - 300

JO - Indian Journal of Pharmaceutical Education and Research

JF - Indian Journal of Pharmaceutical Education and Research

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