Drug utilization pattern in urinary tract infections

A retrospective study

Dhananjay Kumar Pandey, Hardeep, Mujawar Jahir Rauf, Rakesh Kumar, Mohd Faheem Mubeen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Urinary tract infections (UTI) are a frequent problem in primary care; consequently most cases are considered uncomplicated UTI. Etiology is influenced by factors such as age, diabetes, spinal cord injury, urinary catheterization, and other factors. Escherichia coli cause 80-85% of acute episodes of uncomplicated cystitis. Staphylococcus saprophyticus, proteus mirabilis, streptococcus agalactiae and klebsiella species are responsible for most of the remaining episodes. The empirical treatment of UTI requires constant updating of the antibiotic sensitivity of the main uropathogens of the area, country or institution. The study was designed as a retrospective study in 300 patients of mild to moderate Urinary Tract Infection. The case record files were retrieved from the medical records department based on the ICD-10 disease coding. The demographic were recorded. Total admissions, first admission and readmissions were identified and medication status of all patients at admission and at discharge was ascertained. Comparison of various groups of drugs prescribed in 4 major groups (1-20 years, 21-40 years, 41-60 years, >60 years) of patients on admission and on discharge. A total of 300 patients were included in the study, out of which 147 were males and 153 were females. The mean duration of hospital stay was 4.3 days and with a minimum duration of two days hospitalization and maximum of 10 days hospitalization. 30 % admitted patients receive combination of two antibiotics (cephalosporin+ aminoglycoside) as a part of treatment and 17 % received a combination of 3 antibiotic(cephalosporin + aminoglycoside + penicillin) while, 53 % patient managed with mono therapy (cephalosporin). 60 % of patients received cephalosporin at discharge, 28% patients were asked to continue with aminoglycoside. The study shows that though use of cephalosporin as first line therapy recommendations may change, clinical practice may still be affected by factors other than the decision of ability to diagnose UTI. There is an increased use of cephalosporin as first line drugs, Irrespective of the causative agent for UTI, which is an unhealthy practice. The use of cephalosporin for all types of UTI is also on the increased. These results should inform education of health professionals and rational drug use policies to reduce poly-pharmacy.

Original languageEnglish
Pages (from-to)1231-1235
Number of pages5
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume3
Issue number4
Publication statusPublished - 01-10-2012
Externally publishedYes

Fingerprint

Drug Utilization
Cephalosporins
Urinary Tract Infections
Retrospective Studies
Pharmaceutical Preparations
Aminoglycosides
Patient Admission
Hospitalization
Hospital Medical Records Department
Staphylococcus saprophyticus
Urinary Catheterization
Proteus mirabilis
Professional Education
Streptococcus agalactiae
Cystitis
Klebsiella
Patient Discharge
International Classification of Diseases
Therapeutics
Medical problems

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Pandey, Dhananjay Kumar ; Hardeep ; Rauf, Mujawar Jahir ; Kumar, Rakesh ; Mubeen, Mohd Faheem. / Drug utilization pattern in urinary tract infections : A retrospective study. In: Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2012 ; Vol. 3, No. 4. pp. 1231-1235.
@article{d486c4f44c73407fa9682664198cce22,
title = "Drug utilization pattern in urinary tract infections: A retrospective study",
abstract = "Urinary tract infections (UTI) are a frequent problem in primary care; consequently most cases are considered uncomplicated UTI. Etiology is influenced by factors such as age, diabetes, spinal cord injury, urinary catheterization, and other factors. Escherichia coli cause 80-85{\%} of acute episodes of uncomplicated cystitis. Staphylococcus saprophyticus, proteus mirabilis, streptococcus agalactiae and klebsiella species are responsible for most of the remaining episodes. The empirical treatment of UTI requires constant updating of the antibiotic sensitivity of the main uropathogens of the area, country or institution. The study was designed as a retrospective study in 300 patients of mild to moderate Urinary Tract Infection. The case record files were retrieved from the medical records department based on the ICD-10 disease coding. The demographic were recorded. Total admissions, first admission and readmissions were identified and medication status of all patients at admission and at discharge was ascertained. Comparison of various groups of drugs prescribed in 4 major groups (1-20 years, 21-40 years, 41-60 years, >60 years) of patients on admission and on discharge. A total of 300 patients were included in the study, out of which 147 were males and 153 were females. The mean duration of hospital stay was 4.3 days and with a minimum duration of two days hospitalization and maximum of 10 days hospitalization. 30 {\%} admitted patients receive combination of two antibiotics (cephalosporin+ aminoglycoside) as a part of treatment and 17 {\%} received a combination of 3 antibiotic(cephalosporin + aminoglycoside + penicillin) while, 53 {\%} patient managed with mono therapy (cephalosporin). 60 {\%} of patients received cephalosporin at discharge, 28{\%} patients were asked to continue with aminoglycoside. The study shows that though use of cephalosporin as first line therapy recommendations may change, clinical practice may still be affected by factors other than the decision of ability to diagnose UTI. There is an increased use of cephalosporin as first line drugs, Irrespective of the causative agent for UTI, which is an unhealthy practice. The use of cephalosporin for all types of UTI is also on the increased. These results should inform education of health professionals and rational drug use policies to reduce poly-pharmacy.",
author = "Pandey, {Dhananjay Kumar} and Hardeep and Rauf, {Mujawar Jahir} and Rakesh Kumar and Mubeen, {Mohd Faheem}",
year = "2012",
month = "10",
day = "1",
language = "English",
volume = "3",
pages = "1231--1235",
journal = "Research Journal of Pharmaceutical, Biological and Chemical Sciences",
issn = "0975-8585",
publisher = "RJPBCS",
number = "4",

}

Drug utilization pattern in urinary tract infections : A retrospective study. / Pandey, Dhananjay Kumar; Hardeep; Rauf, Mujawar Jahir; Kumar, Rakesh; Mubeen, Mohd Faheem.

In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 3, No. 4, 01.10.2012, p. 1231-1235.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Drug utilization pattern in urinary tract infections

T2 - A retrospective study

AU - Pandey, Dhananjay Kumar

AU - Hardeep,

AU - Rauf, Mujawar Jahir

AU - Kumar, Rakesh

AU - Mubeen, Mohd Faheem

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Urinary tract infections (UTI) are a frequent problem in primary care; consequently most cases are considered uncomplicated UTI. Etiology is influenced by factors such as age, diabetes, spinal cord injury, urinary catheterization, and other factors. Escherichia coli cause 80-85% of acute episodes of uncomplicated cystitis. Staphylococcus saprophyticus, proteus mirabilis, streptococcus agalactiae and klebsiella species are responsible for most of the remaining episodes. The empirical treatment of UTI requires constant updating of the antibiotic sensitivity of the main uropathogens of the area, country or institution. The study was designed as a retrospective study in 300 patients of mild to moderate Urinary Tract Infection. The case record files were retrieved from the medical records department based on the ICD-10 disease coding. The demographic were recorded. Total admissions, first admission and readmissions were identified and medication status of all patients at admission and at discharge was ascertained. Comparison of various groups of drugs prescribed in 4 major groups (1-20 years, 21-40 years, 41-60 years, >60 years) of patients on admission and on discharge. A total of 300 patients were included in the study, out of which 147 were males and 153 were females. The mean duration of hospital stay was 4.3 days and with a minimum duration of two days hospitalization and maximum of 10 days hospitalization. 30 % admitted patients receive combination of two antibiotics (cephalosporin+ aminoglycoside) as a part of treatment and 17 % received a combination of 3 antibiotic(cephalosporin + aminoglycoside + penicillin) while, 53 % patient managed with mono therapy (cephalosporin). 60 % of patients received cephalosporin at discharge, 28% patients were asked to continue with aminoglycoside. The study shows that though use of cephalosporin as first line therapy recommendations may change, clinical practice may still be affected by factors other than the decision of ability to diagnose UTI. There is an increased use of cephalosporin as first line drugs, Irrespective of the causative agent for UTI, which is an unhealthy practice. The use of cephalosporin for all types of UTI is also on the increased. These results should inform education of health professionals and rational drug use policies to reduce poly-pharmacy.

AB - Urinary tract infections (UTI) are a frequent problem in primary care; consequently most cases are considered uncomplicated UTI. Etiology is influenced by factors such as age, diabetes, spinal cord injury, urinary catheterization, and other factors. Escherichia coli cause 80-85% of acute episodes of uncomplicated cystitis. Staphylococcus saprophyticus, proteus mirabilis, streptococcus agalactiae and klebsiella species are responsible for most of the remaining episodes. The empirical treatment of UTI requires constant updating of the antibiotic sensitivity of the main uropathogens of the area, country or institution. The study was designed as a retrospective study in 300 patients of mild to moderate Urinary Tract Infection. The case record files were retrieved from the medical records department based on the ICD-10 disease coding. The demographic were recorded. Total admissions, first admission and readmissions were identified and medication status of all patients at admission and at discharge was ascertained. Comparison of various groups of drugs prescribed in 4 major groups (1-20 years, 21-40 years, 41-60 years, >60 years) of patients on admission and on discharge. A total of 300 patients were included in the study, out of which 147 were males and 153 were females. The mean duration of hospital stay was 4.3 days and with a minimum duration of two days hospitalization and maximum of 10 days hospitalization. 30 % admitted patients receive combination of two antibiotics (cephalosporin+ aminoglycoside) as a part of treatment and 17 % received a combination of 3 antibiotic(cephalosporin + aminoglycoside + penicillin) while, 53 % patient managed with mono therapy (cephalosporin). 60 % of patients received cephalosporin at discharge, 28% patients were asked to continue with aminoglycoside. The study shows that though use of cephalosporin as first line therapy recommendations may change, clinical practice may still be affected by factors other than the decision of ability to diagnose UTI. There is an increased use of cephalosporin as first line drugs, Irrespective of the causative agent for UTI, which is an unhealthy practice. The use of cephalosporin for all types of UTI is also on the increased. These results should inform education of health professionals and rational drug use policies to reduce poly-pharmacy.

UR - http://www.scopus.com/inward/record.url?scp=84874533789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874533789&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 1231

EP - 1235

JO - Research Journal of Pharmaceutical, Biological and Chemical Sciences

JF - Research Journal of Pharmaceutical, Biological and Chemical Sciences

SN - 0975-8585

IS - 4

ER -