Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke: A clinical practice guideline

Kameshwar Prasad, Reed Siemieniuk, Qiukui Hao, Gordon Guyatt, Martin O'Donnell, Lyubov Lytvyn, Anja Fog Heen, Thomas Agoritsas, Per Olav Vandvik, Sankar Prasad Gorthi, Loraine Fisch, Mirza Jusufovic, Jennifer Muller, Brenda Booth, Eleanor Horton, Auxiliadora Fraiz, Jillian Siemieniuk, Awah Cletus Fobuzi, Neelima Katragunta, Bram Rochwerg

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Abstract

What is the role of dual antiplatelet therapy after high risk transient ischaemic attack or minor stroke? Specifically, does dual antiplatelet therapy with a combination of aspirin and clopidogrel lead to a greater reduction in recurrent stroke and death over the use of aspirin alone when given in the first 24 hours after a high risk transient ischaemic attack or minor ischaemic stroke? An expert panel produced a strong recommendation for initiating dual antiplatelet therapy within 24 hours of the onset of symptoms, and for continuing it for 10-21 days. Current practice is typically to use a single drug.

Original languageEnglish
Article numberk5130
JournalBMJ (Online)
Volume363
DOIs
Publication statusPublished - 01-01-2018

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Prasad, K., Siemieniuk, R., Hao, Q., Guyatt, G., O'Donnell, M., Lytvyn, L., Heen, A. F., Agoritsas, T., Vandvik, P. O., Gorthi, S. P., Fisch, L., Jusufovic, M., Muller, J., Booth, B., Horton, E., Fraiz, A., Siemieniuk, J., Fobuzi, A. C., Katragunta, N., & Rochwerg, B. (2018). Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke: A clinical practice guideline. BMJ (Online), 363, [k5130]. https://doi.org/10.1136/bmj.k5130