Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke

A clinical practice guideline

Kameshwar Prasad, Reed Siemieniuk, Qiukui Hao, Gordon Guyatt, Martin O'Donnell, Lyubov Lytvyn, Anja Fog Heen, Thomas Agoritsas, Per Olav Vandvik, Sankar Prasad Gorthi, Loraine Fisch, Mirza Jusufovic, Jennifer Muller, Brenda Booth, Eleanor Horton, Auxiliadora Fraiz, Jillian Siemieniuk, Awah Cletus Fobuzi, Neelima Katragunta, Bram Rochwerg

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

What is the role of dual antiplatelet therapy after high risk transient ischaemic attack or minor stroke? Specifically, does dual antiplatelet therapy with a combination of aspirin and clopidogrel lead to a greater reduction in recurrent stroke and death over the use of aspirin alone when given in the first 24 hours after a high risk transient ischaemic attack or minor ischaemic stroke? An expert panel produced a strong recommendation for initiating dual antiplatelet therapy within 24 hours of the onset of symptoms, and for continuing it for 10-21 days. Current practice is typically to use a single drug.

Original languageEnglish
Article numberk5130
JournalBMJ (Online)
Volume363
DOIs
Publication statusPublished - 01-01-2018

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clopidogrel
Transient Ischemic Attack
Practice Guidelines
Aspirin
Stroke
Therapeutics
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Prasad, Kameshwar ; Siemieniuk, Reed ; Hao, Qiukui ; Guyatt, Gordon ; O'Donnell, Martin ; Lytvyn, Lyubov ; Heen, Anja Fog ; Agoritsas, Thomas ; Vandvik, Per Olav ; Gorthi, Sankar Prasad ; Fisch, Loraine ; Jusufovic, Mirza ; Muller, Jennifer ; Booth, Brenda ; Horton, Eleanor ; Fraiz, Auxiliadora ; Siemieniuk, Jillian ; Fobuzi, Awah Cletus ; Katragunta, Neelima ; Rochwerg, Bram. / Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke : A clinical practice guideline. In: BMJ (Online). 2018 ; Vol. 363.
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Prasad, K, Siemieniuk, R, Hao, Q, Guyatt, G, O'Donnell, M, Lytvyn, L, Heen, AF, Agoritsas, T, Vandvik, PO, Gorthi, SP, Fisch, L, Jusufovic, M, Muller, J, Booth, B, Horton, E, Fraiz, A, Siemieniuk, J, Fobuzi, AC, Katragunta, N & Rochwerg, B 2018, 'Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke: A clinical practice guideline', BMJ (Online), vol. 363, k5130. https://doi.org/10.1136/bmj.k5130

Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke : A clinical practice guideline. / Prasad, Kameshwar; Siemieniuk, Reed; Hao, Qiukui; Guyatt, Gordon; O'Donnell, Martin; Lytvyn, Lyubov; Heen, Anja Fog; Agoritsas, Thomas; Vandvik, Per Olav; Gorthi, Sankar Prasad; Fisch, Loraine; Jusufovic, Mirza; Muller, Jennifer; Booth, Brenda; Horton, Eleanor; Fraiz, Auxiliadora; Siemieniuk, Jillian; Fobuzi, Awah Cletus; Katragunta, Neelima; Rochwerg, Bram.

In: BMJ (Online), Vol. 363, k5130, 01.01.2018.

Research output: Contribution to journalArticle

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T2 - A clinical practice guideline

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AU - Siemieniuk, Reed

AU - Hao, Qiukui

AU - Guyatt, Gordon

AU - O'Donnell, Martin

AU - Lytvyn, Lyubov

AU - Heen, Anja Fog

AU - Agoritsas, Thomas

AU - Vandvik, Per Olav

AU - Gorthi, Sankar Prasad

AU - Fisch, Loraine

AU - Jusufovic, Mirza

AU - Muller, Jennifer

AU - Booth, Brenda

AU - Horton, Eleanor

AU - Fraiz, Auxiliadora

AU - Siemieniuk, Jillian

AU - Fobuzi, Awah Cletus

AU - Katragunta, Neelima

AU - Rochwerg, Bram

PY - 2018/1/1

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