E-Cadherin expression: A diagnostic utility for differentiating breast carcinomas with ductal and lobular morphologies

Kanthilatha Pai, Poornima Baliga, Bishwo Lal Shrestha

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10 Citations (Scopus)


Objectives: The objective of this study was to evaluate the diagnostic utility of the E-Cadherin (EC) expression in differentiating between an infiltrating ductal carcinoma (IDC) and an infiltrating lobular carcinoma (ILC), the two most common forms of invasive breast carcinomas. Methods: The authors evaluated the E-Cadherin expression by doing immunohistochemistical studies of all the cases of invasive lobular carcinomas (ILC) which were diagnosed in the pathology laboratory during a 3 year period and they compared the expression of E-Cadherin in an equal number of invasive ductal carcinomas (IDC) of the breast. Results: A moderate to strong inter-membranous E-Cadherin expression on immunohistochemistry was seen in all the cases of IDC, while only 1 case of ILC showed a moderate E-Cadherin expression. Hence, the E-cadherin expression can be reliably used as a marker to differentiate IDC and ILC. However, an aberrant cytoplasmic expression of E-Cadherin may be seen in some cases of ILC, which should be interpreted with caution.

Original languageEnglish
Pages (from-to)840-844
Number of pages5
JournalJournal of Clinical and Diagnostic Research
Issue number5
Publication statusPublished - 01-05-2013


All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Clinical Biochemistry

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