(E)4-[4-N,N-dimethylaminophenyl]but-3-en-2-one (DMAP) treatment inhibits the radiation-induced micronucleus formation in bone marrow of BALB/c mice

G.C. Jagetia, P.S. Jacob, M.N.A. Rao

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Abstract

The frequency of micronucleated polychromatic (MPCE) and normochromatic erythrocytes (MNCE) and polychromatic/normochromatic erythrocyte ratio (P/N ratio) was studied in the bone marrow of BALB/c mice administered with 20 mg/kg body weight of (E)4-[4-N,N-dimethylaminophenyl]but-3-en-2-one (DMAP), a phenyl-butenone derivative, 30 min before exposure to different doses of 60Co γ-radiation. A dose-dependent increase in the frequency of MPCE and MNCE was observed in double-distilled water (DDW) or oil + irradiated and DMAP + irradiated groups. The frequency of MPCE and MNCE was significantly less in the DMAP + irradiated group when compared to the DDW or oil + irradiated groups at all the irradiation doses studied. The P/N ratio declined with increasing radiation dose in DDW or oil + irradiated and DMAP + irradiated groups. The inhibitory effect of irradiation on the P/N ratio was less in the DMAP + irradiated group as compared to the DDW or oil + irradiated groups, as evidence by the higher P/N ratio in the former than the latter. The P/N ratio was significantly higher in the DMAP + irradiated group from 1 Gy irradiation onwards. The dose-response relationship was linear-quadratic for MPCE, MNCE and P/N ratio for all the groups studied. © 1994.
Original languageUndefined/Unknown
Pages (from-to)71-80
Number of pages10
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume306
Issue number1
DOIs
Publication statusPublished - 1994

Cite this

@article{02a03b0f71184c68ab4327fe932bfdfe,
title = "(E)4-[4-N,N-dimethylaminophenyl]but-3-en-2-one (DMAP) treatment inhibits the radiation-induced micronucleus formation in bone marrow of BALB/c mice",
abstract = "The frequency of micronucleated polychromatic (MPCE) and normochromatic erythrocytes (MNCE) and polychromatic/normochromatic erythrocyte ratio (P/N ratio) was studied in the bone marrow of BALB/c mice administered with 20 mg/kg body weight of (E)4-[4-N,N-dimethylaminophenyl]but-3-en-2-one (DMAP), a phenyl-butenone derivative, 30 min before exposure to different doses of 60Co γ-radiation. A dose-dependent increase in the frequency of MPCE and MNCE was observed in double-distilled water (DDW) or oil + irradiated and DMAP + irradiated groups. The frequency of MPCE and MNCE was significantly less in the DMAP + irradiated group when compared to the DDW or oil + irradiated groups at all the irradiation doses studied. The P/N ratio declined with increasing radiation dose in DDW or oil + irradiated and DMAP + irradiated groups. The inhibitory effect of irradiation on the P/N ratio was less in the DMAP + irradiated group as compared to the DDW or oil + irradiated groups, as evidence by the higher P/N ratio in the former than the latter. The P/N ratio was significantly higher in the DMAP + irradiated group from 1 Gy irradiation onwards. The dose-response relationship was linear-quadratic for MPCE, MNCE and P/N ratio for all the groups studied. {\circledC} 1994.",
author = "G.C. Jagetia and P.S. Jacob and M.N.A. Rao",
note = "cited By 9",
year = "1994",
doi = "10.1016/0027-5107(94)90168-6",
language = "Undefined/Unknown",
volume = "306",
pages = "71--80",
journal = "Mutation Research",
issn = "1386-1964",
publisher = "Elsevier",
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T1 - (E)4-[4-N,N-dimethylaminophenyl]but-3-en-2-one (DMAP) treatment inhibits the radiation-induced micronucleus formation in bone marrow of BALB/c mice

AU - Jagetia, G.C.

AU - Jacob, P.S.

AU - Rao, M.N.A.

N1 - cited By 9

PY - 1994

Y1 - 1994

N2 - The frequency of micronucleated polychromatic (MPCE) and normochromatic erythrocytes (MNCE) and polychromatic/normochromatic erythrocyte ratio (P/N ratio) was studied in the bone marrow of BALB/c mice administered with 20 mg/kg body weight of (E)4-[4-N,N-dimethylaminophenyl]but-3-en-2-one (DMAP), a phenyl-butenone derivative, 30 min before exposure to different doses of 60Co γ-radiation. A dose-dependent increase in the frequency of MPCE and MNCE was observed in double-distilled water (DDW) or oil + irradiated and DMAP + irradiated groups. The frequency of MPCE and MNCE was significantly less in the DMAP + irradiated group when compared to the DDW or oil + irradiated groups at all the irradiation doses studied. The P/N ratio declined with increasing radiation dose in DDW or oil + irradiated and DMAP + irradiated groups. The inhibitory effect of irradiation on the P/N ratio was less in the DMAP + irradiated group as compared to the DDW or oil + irradiated groups, as evidence by the higher P/N ratio in the former than the latter. The P/N ratio was significantly higher in the DMAP + irradiated group from 1 Gy irradiation onwards. The dose-response relationship was linear-quadratic for MPCE, MNCE and P/N ratio for all the groups studied. © 1994.

AB - The frequency of micronucleated polychromatic (MPCE) and normochromatic erythrocytes (MNCE) and polychromatic/normochromatic erythrocyte ratio (P/N ratio) was studied in the bone marrow of BALB/c mice administered with 20 mg/kg body weight of (E)4-[4-N,N-dimethylaminophenyl]but-3-en-2-one (DMAP), a phenyl-butenone derivative, 30 min before exposure to different doses of 60Co γ-radiation. A dose-dependent increase in the frequency of MPCE and MNCE was observed in double-distilled water (DDW) or oil + irradiated and DMAP + irradiated groups. The frequency of MPCE and MNCE was significantly less in the DMAP + irradiated group when compared to the DDW or oil + irradiated groups at all the irradiation doses studied. The P/N ratio declined with increasing radiation dose in DDW or oil + irradiated and DMAP + irradiated groups. The inhibitory effect of irradiation on the P/N ratio was less in the DMAP + irradiated group as compared to the DDW or oil + irradiated groups, as evidence by the higher P/N ratio in the former than the latter. The P/N ratio was significantly higher in the DMAP + irradiated group from 1 Gy irradiation onwards. The dose-response relationship was linear-quadratic for MPCE, MNCE and P/N ratio for all the groups studied. © 1994.

U2 - 10.1016/0027-5107(94)90168-6

DO - 10.1016/0027-5107(94)90168-6

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VL - 306

SP - 71

EP - 80

JO - Mutation Research

JF - Mutation Research

SN - 1386-1964

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