Ecogenetics of lead toxicity and its influence on risk assessment

M. S. Mani, S. P. Kabekkodu, M. B. Joshi, H. S. Dsouza

Research output: Contribution to journalArticle

Abstract

Lead (Pb) toxicity is a public health problem affecting millions worldwide. Advances in ‘omic’ technology have paved the way to toxico-genomics which is currently revolutionizing the understanding of interindividual variations in susceptibility to Pb toxicity and its functional consequences to exposure. Our objective was to identify, comprehensively analyze, and curate all the potential genetic and epigenetic biomarkers studied to date in relation to Pb toxicity and its association with diseases. We screened a volume of research articles that focused on Pb toxicity and its association with genetic and epigenetic signatures in the perspective of occupational and environmental Pb exposure. Due to wide variations in population size, ethnicity, age-groups, and source of exposure in different studies, researchers continue to be skeptical on the topic of the influence of genetic variations in Pb toxicity. However, surface knowledge of the underlying genetic factors will aid in elucidating the mechanism of action of Pb. Moreover, in recent years, the application of epigenetics in Pb toxicity has become a promising area in toxicology to understand the influence of epigenetic mechanisms such as DNA methylation, chromatin remodeling, and small RNAs for the regulation of genes in response to Pb exposure during early life. Growing evidences of ecogenetic understanding (both genetic and epigenetic processes) in a dose-dependent manner may help uncover the mechanism of action of Pb and in the identification of susceptible groups. Such studies will further help in refining uncertainty factors and in addressing risk assessment of Pb poisoning.

Original languageEnglish
Pages (from-to)1031-1059
Number of pages29
JournalHuman and Experimental Toxicology
Volume38
Issue number9
DOIs
Publication statusPublished - 01-09-2019

Fingerprint

Epigenomics
Risk assessment
Toxicity
Genetic Epigenesis
Genetic Phenomena
Social Identification
Chromatin Assembly and Disassembly
Environmental Exposure
DNA Methylation
Population Density
Genomics
Association reactions
Toxicology
Poisoning
Uncertainty
Public Health
Age Groups
Biomarkers
Research Personnel
Public health

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

@article{56a53f6896e74f72812fb36a9c436e57,
title = "Ecogenetics of lead toxicity and its influence on risk assessment",
abstract = "Lead (Pb) toxicity is a public health problem affecting millions worldwide. Advances in ‘omic’ technology have paved the way to toxico-genomics which is currently revolutionizing the understanding of interindividual variations in susceptibility to Pb toxicity and its functional consequences to exposure. Our objective was to identify, comprehensively analyze, and curate all the potential genetic and epigenetic biomarkers studied to date in relation to Pb toxicity and its association with diseases. We screened a volume of research articles that focused on Pb toxicity and its association with genetic and epigenetic signatures in the perspective of occupational and environmental Pb exposure. Due to wide variations in population size, ethnicity, age-groups, and source of exposure in different studies, researchers continue to be skeptical on the topic of the influence of genetic variations in Pb toxicity. However, surface knowledge of the underlying genetic factors will aid in elucidating the mechanism of action of Pb. Moreover, in recent years, the application of epigenetics in Pb toxicity has become a promising area in toxicology to understand the influence of epigenetic mechanisms such as DNA methylation, chromatin remodeling, and small RNAs for the regulation of genes in response to Pb exposure during early life. Growing evidences of ecogenetic understanding (both genetic and epigenetic processes) in a dose-dependent manner may help uncover the mechanism of action of Pb and in the identification of susceptible groups. Such studies will further help in refining uncertainty factors and in addressing risk assessment of Pb poisoning.",
author = "Mani, {M. S.} and Kabekkodu, {S. P.} and Joshi, {M. B.} and Dsouza, {H. S.}",
year = "2019",
month = "9",
day = "1",
doi = "10.1177/0960327119851253",
language = "English",
volume = "38",
pages = "1031--1059",
journal = "Human and Experimental Toxicology",
issn = "0960-3271",
publisher = "SAGE Publications Inc.",
number = "9",

}

Ecogenetics of lead toxicity and its influence on risk assessment. / Mani, M. S.; Kabekkodu, S. P.; Joshi, M. B.; Dsouza, H. S.

In: Human and Experimental Toxicology, Vol. 38, No. 9, 01.09.2019, p. 1031-1059.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ecogenetics of lead toxicity and its influence on risk assessment

AU - Mani, M. S.

AU - Kabekkodu, S. P.

AU - Joshi, M. B.

AU - Dsouza, H. S.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Lead (Pb) toxicity is a public health problem affecting millions worldwide. Advances in ‘omic’ technology have paved the way to toxico-genomics which is currently revolutionizing the understanding of interindividual variations in susceptibility to Pb toxicity and its functional consequences to exposure. Our objective was to identify, comprehensively analyze, and curate all the potential genetic and epigenetic biomarkers studied to date in relation to Pb toxicity and its association with diseases. We screened a volume of research articles that focused on Pb toxicity and its association with genetic and epigenetic signatures in the perspective of occupational and environmental Pb exposure. Due to wide variations in population size, ethnicity, age-groups, and source of exposure in different studies, researchers continue to be skeptical on the topic of the influence of genetic variations in Pb toxicity. However, surface knowledge of the underlying genetic factors will aid in elucidating the mechanism of action of Pb. Moreover, in recent years, the application of epigenetics in Pb toxicity has become a promising area in toxicology to understand the influence of epigenetic mechanisms such as DNA methylation, chromatin remodeling, and small RNAs for the regulation of genes in response to Pb exposure during early life. Growing evidences of ecogenetic understanding (both genetic and epigenetic processes) in a dose-dependent manner may help uncover the mechanism of action of Pb and in the identification of susceptible groups. Such studies will further help in refining uncertainty factors and in addressing risk assessment of Pb poisoning.

AB - Lead (Pb) toxicity is a public health problem affecting millions worldwide. Advances in ‘omic’ technology have paved the way to toxico-genomics which is currently revolutionizing the understanding of interindividual variations in susceptibility to Pb toxicity and its functional consequences to exposure. Our objective was to identify, comprehensively analyze, and curate all the potential genetic and epigenetic biomarkers studied to date in relation to Pb toxicity and its association with diseases. We screened a volume of research articles that focused on Pb toxicity and its association with genetic and epigenetic signatures in the perspective of occupational and environmental Pb exposure. Due to wide variations in population size, ethnicity, age-groups, and source of exposure in different studies, researchers continue to be skeptical on the topic of the influence of genetic variations in Pb toxicity. However, surface knowledge of the underlying genetic factors will aid in elucidating the mechanism of action of Pb. Moreover, in recent years, the application of epigenetics in Pb toxicity has become a promising area in toxicology to understand the influence of epigenetic mechanisms such as DNA methylation, chromatin remodeling, and small RNAs for the regulation of genes in response to Pb exposure during early life. Growing evidences of ecogenetic understanding (both genetic and epigenetic processes) in a dose-dependent manner may help uncover the mechanism of action of Pb and in the identification of susceptible groups. Such studies will further help in refining uncertainty factors and in addressing risk assessment of Pb poisoning.

UR - http://www.scopus.com/inward/record.url?scp=85066855040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066855040&partnerID=8YFLogxK

U2 - 10.1177/0960327119851253

DO - 10.1177/0960327119851253

M3 - Article

VL - 38

SP - 1031

EP - 1059

JO - Human and Experimental Toxicology

JF - Human and Experimental Toxicology

SN - 0960-3271

IS - 9

ER -