Effect of acute and chronic administration of losartan, atorvastatin and their combination on animal models of epilepsy

Sanjeev Kumar, M. Megha, Bharti Chogtu, K. L. Bairy

Research output: Contribution to journalArticle

Abstract

To study and compare the antiepileptic effect of losartan, atorvastatin and their combination in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy. The study was divided into acute and chronic stages. In acute study, 60 rats were taken and divided into 30 in each MES & PTZ model. Seizure was induced using maximum electroshock (MES) and pentylenetetrazole (PTZ). In each model, animals were further divided into five groups (n=6). Rats from group I to group V were treated with gum acacia 2% (1ml/kg), phenytoin (25mg/kg) in MES model or sodium valproate (200mg/kg) in PTZ model, Losartan (50mg/kg), Atorvastatin (10mg/kg) and Losartan + Atorvastatin (50mg+10mg/kg) respectively. Chronic study was performed in a similar way as acute study after dosing same drugs and dose for duration of six weeks. Hind limb extension time was noted in MES model whereas latency for myoclonic jerk, seizure and mortality in in PTZ model. In acute study, losartan showed significant anti-seizure activity in both the models while atorvastatin and combination did not show any effect. In chronic treatment losartan showed significant effect in both MES and PTZ model whereas 83.33% of survival rate was observed in atorvastatin group. Losartan has broad spectrum activity against seizure while atorvastatin is efficacious only on chronic treatment. Combination of these two drugs offers no advantage against seizure.

Original languageEnglish
Pages (from-to)1795-1801
Number of pages7
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume6
Issue number4
Publication statusPublished - 01-01-2015

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Electroshock
Pentylenetetrazole
Losartan
Epilepsy
Animals
Animal Models
Seizures
Rats
Gum Arabic
Myoclonus
Valproic Acid
Phenytoin
Drug Combinations
Anticonvulsants
Atorvastatin Calcium
Survival Rate
Extremities
Pharmaceutical Preparations
Mortality

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "To study and compare the antiepileptic effect of losartan, atorvastatin and their combination in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy. The study was divided into acute and chronic stages. In acute study, 60 rats were taken and divided into 30 in each MES & PTZ model. Seizure was induced using maximum electroshock (MES) and pentylenetetrazole (PTZ). In each model, animals were further divided into five groups (n=6). Rats from group I to group V were treated with gum acacia 2{\%} (1ml/kg), phenytoin (25mg/kg) in MES model or sodium valproate (200mg/kg) in PTZ model, Losartan (50mg/kg), Atorvastatin (10mg/kg) and Losartan + Atorvastatin (50mg+10mg/kg) respectively. Chronic study was performed in a similar way as acute study after dosing same drugs and dose for duration of six weeks. Hind limb extension time was noted in MES model whereas latency for myoclonic jerk, seizure and mortality in in PTZ model. In acute study, losartan showed significant anti-seizure activity in both the models while atorvastatin and combination did not show any effect. In chronic treatment losartan showed significant effect in both MES and PTZ model whereas 83.33{\%} of survival rate was observed in atorvastatin group. Losartan has broad spectrum activity against seizure while atorvastatin is efficacious only on chronic treatment. Combination of these two drugs offers no advantage against seizure.",
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Effect of acute and chronic administration of losartan, atorvastatin and their combination on animal models of epilepsy. / Kumar, Sanjeev; Megha, M.; Chogtu, Bharti; Bairy, K. L.

In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 6, No. 4, 01.01.2015, p. 1795-1801.

Research output: Contribution to journalArticle

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