Effect of acyclovir on the sperm parameters of albino mice

K. L. Bairy, Ganesh Kumar, Yeshwanth Karkal Rao

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A number of animal studies as well as human epidemiological studies have demonstrated that exposure of males to various agents could result in abnormal reproductive toxicity. Acyclovir (ACV) is known to be toxic to gonads, but fails to provide the in-depth analyses of timing of damage, the types of germ cells affected, dose and the duration of damage and timing of reversal of fertility. Hence this study on sperm morphology, sperm count and sperm motility. Doses of 4 mg, 16 mg, 32 mg and 48 mg/kg body weight of ACV were administered to 9-12 weeks old male swiss albino mice by intraperitoneal route for 15 days continuously. One hundred and eighty animals were segregated into 30 groups (N=6). Twenty four groups were injected with acyclovir (4 mg, 8 mg, 16 mg and 32 mg/kg bodyweight) and the rest six groups served as control. After the last treatment, the animals were sacrificed on 7, 14, 21, 28, 35 and 70 days sample times and the sperm parameters were estimated. ACV causes increased incidence of abnormal sperms on most of the dose ranges from day 21 to 35 indicating the effect on spermatocytes and spermatogonial cells. ACV is cytotoxic to the testis. It causes oligospermia from day 7 to day 35 after the last exposure. It also decreased the sperm motility on same time points. All these effects were reversible by day 70. ACV exerts reversible genotoxic and cytotoxic effect on germ cells. ACV does not affect stem cell lines of spermatogenesis since all sperm parameters return to control level on day 70.

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalIndian Journal of Physiology and Pharmacology
Volume53
Issue number4
Publication statusPublished - 01-10-2009

Fingerprint

Acyclovir
Spermatozoa
Sperm Motility
Germ Cells
Oligospermia
Spermatocytes
Sperm Count
Poisons
Gonads
Spermatogenesis
Fertility
Testis
Epidemiologic Studies
Stem Cells
Body Weight
Cell Line
Incidence

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

@article{aed13e39db0547c7991d99085729b7e7,
title = "Effect of acyclovir on the sperm parameters of albino mice",
abstract = "A number of animal studies as well as human epidemiological studies have demonstrated that exposure of males to various agents could result in abnormal reproductive toxicity. Acyclovir (ACV) is known to be toxic to gonads, but fails to provide the in-depth analyses of timing of damage, the types of germ cells affected, dose and the duration of damage and timing of reversal of fertility. Hence this study on sperm morphology, sperm count and sperm motility. Doses of 4 mg, 16 mg, 32 mg and 48 mg/kg body weight of ACV were administered to 9-12 weeks old male swiss albino mice by intraperitoneal route for 15 days continuously. One hundred and eighty animals were segregated into 30 groups (N=6). Twenty four groups were injected with acyclovir (4 mg, 8 mg, 16 mg and 32 mg/kg bodyweight) and the rest six groups served as control. After the last treatment, the animals were sacrificed on 7, 14, 21, 28, 35 and 70 days sample times and the sperm parameters were estimated. ACV causes increased incidence of abnormal sperms on most of the dose ranges from day 21 to 35 indicating the effect on spermatocytes and spermatogonial cells. ACV is cytotoxic to the testis. It causes oligospermia from day 7 to day 35 after the last exposure. It also decreased the sperm motility on same time points. All these effects were reversible by day 70. ACV exerts reversible genotoxic and cytotoxic effect on germ cells. ACV does not affect stem cell lines of spermatogenesis since all sperm parameters return to control level on day 70.",
author = "Bairy, {K. L.} and Ganesh Kumar and Rao, {Yeshwanth Karkal}",
year = "2009",
month = "10",
day = "1",
language = "English",
volume = "53",
pages = "327--333",
journal = "Indian Journal of Physiology and Pharmacology",
issn = "0019-5499",
publisher = "Association of Physiologists and Pharmacologists of India",
number = "4",

}

Effect of acyclovir on the sperm parameters of albino mice. / Bairy, K. L.; Kumar, Ganesh; Rao, Yeshwanth Karkal.

In: Indian Journal of Physiology and Pharmacology, Vol. 53, No. 4, 01.10.2009, p. 327-333.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of acyclovir on the sperm parameters of albino mice

AU - Bairy, K. L.

AU - Kumar, Ganesh

AU - Rao, Yeshwanth Karkal

PY - 2009/10/1

Y1 - 2009/10/1

N2 - A number of animal studies as well as human epidemiological studies have demonstrated that exposure of males to various agents could result in abnormal reproductive toxicity. Acyclovir (ACV) is known to be toxic to gonads, but fails to provide the in-depth analyses of timing of damage, the types of germ cells affected, dose and the duration of damage and timing of reversal of fertility. Hence this study on sperm morphology, sperm count and sperm motility. Doses of 4 mg, 16 mg, 32 mg and 48 mg/kg body weight of ACV were administered to 9-12 weeks old male swiss albino mice by intraperitoneal route for 15 days continuously. One hundred and eighty animals were segregated into 30 groups (N=6). Twenty four groups were injected with acyclovir (4 mg, 8 mg, 16 mg and 32 mg/kg bodyweight) and the rest six groups served as control. After the last treatment, the animals were sacrificed on 7, 14, 21, 28, 35 and 70 days sample times and the sperm parameters were estimated. ACV causes increased incidence of abnormal sperms on most of the dose ranges from day 21 to 35 indicating the effect on spermatocytes and spermatogonial cells. ACV is cytotoxic to the testis. It causes oligospermia from day 7 to day 35 after the last exposure. It also decreased the sperm motility on same time points. All these effects were reversible by day 70. ACV exerts reversible genotoxic and cytotoxic effect on germ cells. ACV does not affect stem cell lines of spermatogenesis since all sperm parameters return to control level on day 70.

AB - A number of animal studies as well as human epidemiological studies have demonstrated that exposure of males to various agents could result in abnormal reproductive toxicity. Acyclovir (ACV) is known to be toxic to gonads, but fails to provide the in-depth analyses of timing of damage, the types of germ cells affected, dose and the duration of damage and timing of reversal of fertility. Hence this study on sperm morphology, sperm count and sperm motility. Doses of 4 mg, 16 mg, 32 mg and 48 mg/kg body weight of ACV were administered to 9-12 weeks old male swiss albino mice by intraperitoneal route for 15 days continuously. One hundred and eighty animals were segregated into 30 groups (N=6). Twenty four groups were injected with acyclovir (4 mg, 8 mg, 16 mg and 32 mg/kg bodyweight) and the rest six groups served as control. After the last treatment, the animals were sacrificed on 7, 14, 21, 28, 35 and 70 days sample times and the sperm parameters were estimated. ACV causes increased incidence of abnormal sperms on most of the dose ranges from day 21 to 35 indicating the effect on spermatocytes and spermatogonial cells. ACV is cytotoxic to the testis. It causes oligospermia from day 7 to day 35 after the last exposure. It also decreased the sperm motility on same time points. All these effects were reversible by day 70. ACV exerts reversible genotoxic and cytotoxic effect on germ cells. ACV does not affect stem cell lines of spermatogenesis since all sperm parameters return to control level on day 70.

UR - http://www.scopus.com/inward/record.url?scp=77953629644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953629644&partnerID=8YFLogxK

M3 - Article

VL - 53

SP - 327

EP - 333

JO - Indian Journal of Physiology and Pharmacology

JF - Indian Journal of Physiology and Pharmacology

SN - 0019-5499

IS - 4

ER -