Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure

A. Shirwaikar, D. Issac, S. Malini

Research output: Contribution to journalArticle

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Abstract

The ethanol extract of the entire plant of Aerva lanata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced acute renal injury in albino rats of either sex. In the curative regimen, the extract at dose levels of 75, 150 and 300mg/kg showed dose-dependent reduction in the elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen . In the gentamicin model the rats in the preventive regimen also showed good response to the ethanol extract at 300mg/kg. The findings suggest that the ethanol extract of Aerva lanata possesses marked nephroprotective activity with minimal toxicity and could offer a promising role in the treatment of acute renal injury caused by nephrotoxins like cisplatin and gentamicin. © 2003 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalJournal of Ethnopharmacology
Volume90
Issue number1
DOIs
Publication statusPublished - 2004

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Amaranthaceae
Gentamicins
Acute Kidney Injury
Cisplatin
Ethanol
Plant Extracts
Ireland
Urea
Creatinine
Serum

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Shirwaikar, A. ; Issac, D. ; Malini, S. / Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure. In: Journal of Ethnopharmacology. 2004 ; Vol. 90, No. 1. pp. 81-86.
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abstract = "The ethanol extract of the entire plant of Aerva lanata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced acute renal injury in albino rats of either sex. In the curative regimen, the extract at dose levels of 75, 150 and 300mg/kg showed dose-dependent reduction in the elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen . In the gentamicin model the rats in the preventive regimen also showed good response to the ethanol extract at 300mg/kg. The findings suggest that the ethanol extract of Aerva lanata possesses marked nephroprotective activity with minimal toxicity and could offer a promising role in the treatment of acute renal injury caused by nephrotoxins like cisplatin and gentamicin. {\circledC} 2003 Elsevier Ireland Ltd. All rights reserved.",
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note = "Cited By :69 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576119, Karnataka, India; email: annie.shirwaikar@cops.manipal.edu Chemicals/CAS: alcohol, 64-17-5; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0 References: Afaq, S.H., Tajuddin, S., Afridi, R., Bisheri Booti (Aerva lanata) some lesser known uses and pharmacognosy (1991) Ethnobotany, 5, pp. 37-40; Amin, K.M.Y., Ahmed, S., Khan, N.A., Antinephrotic syndrome of ethnodrug Bisheri Booti (Aerva lanata) - Experimental study of relevant pharmacological action (1994) Fourth International Congress on Ethnobiology NBRI, Lucknow, 94, pp. 17-21; Barry, M., Brenner, C., (2000) The Kidney, pp. 3-67. , WB Saunders Company, Philadelphia; Chandra, S., Sastry, M.S., Chemical constituents of Aerva lanata (1990) Fitoterapia, 61, p. 188; Ghosh, M.N., 1984. Fundamentals of Experimental Pharmacology. Scientific Book Agency, Calcutta, p. 153; Greggi, A.L.M., Darin, J.D., Bianchi, M.D., Protective effects of Vitamin C against cisplatin induced nephrotoxicity and lipid peroxidation in adult rats: A dose dependent study (2000) Pharmacological Research, 41, pp. 405-411; Harold, V., 1980. Practical Clinical Biochemistry. William Heinemann Medical Books, 5th ed., vol. 1. pp. 451-596; Hayden, P.J., Stevens, J.L., 1990. Cysteine conjugate toxicity, metabolism and macromolecules in isolated rat kidney mitochondria. Molecular Pharmacology 437-468; Laurent, G., Kishore, B.K., Tulkens, P.M., Aminoglycoside-induced renal phospholipidosis and nephrotoxicity (1990) Biochemical Pharmacology, 40, p. 2383; Lindquist, S., The heat shock response (1986) Annual Review of Biochemistry, 55, p. 1151; Sivarajan, V.V., Balachandran, I., 1994. Ayurvedic Drugs and Their Plant Sources. Oxford and IBH Publisher, New Delhi, p. 27; Sreejayan, N., Rao, M.N.A., Nitric oxide scavenging by curcuminoids (1996) Journal of Pharmacy and Pharmacology, 49, pp. 105-107; Ulluwisheva, R.K., Modernisation versus sustainability (1991) Environmental Conservation, 18, pp. 103-109; Vedavathy, S., Rao, K.N., 1990. Ancient Science of Life, vol. IX. pp. 164-167; Vedavathy, S., Mrudula, V.G., Sudhakar, A., 1997. Tribal Medicines of Chitboor District, Andhra Pradesh, India Tirupati Herbal Folklore, 19-20; Zapesochnaya, G., Kurkin, V., Okhavov, V., Hiroshnikov, A., Canthin-6-one and β-carboline alkaloids from Aerva lanata (1992) Planta Medica, 37, pp. 192-196",
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Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure. / Shirwaikar, A.; Issac, D.; Malini, S.

In: Journal of Ethnopharmacology, Vol. 90, No. 1, 2004, p. 81-86.

Research output: Contribution to journalArticle

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T1 - Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure

AU - Shirwaikar, A.

AU - Issac, D.

AU - Malini, S.

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AB - The ethanol extract of the entire plant of Aerva lanata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced acute renal injury in albino rats of either sex. In the curative regimen, the extract at dose levels of 75, 150 and 300mg/kg showed dose-dependent reduction in the elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen . In the gentamicin model the rats in the preventive regimen also showed good response to the ethanol extract at 300mg/kg. The findings suggest that the ethanol extract of Aerva lanata possesses marked nephroprotective activity with minimal toxicity and could offer a promising role in the treatment of acute renal injury caused by nephrotoxins like cisplatin and gentamicin. © 2003 Elsevier Ireland Ltd. All rights reserved.

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