Effect of alpha-tocopherol supplementation on renal oxidative stress and Na+/K+-adenosine triphosphatase in ethanol treated wistar rats

Maneesh Mailankot, H. Jayalekshmi, Amit Chakrabarti, Neha Alang, D. M. Vasudevan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Ethanol intoxication resulted in high extent of lipid peroxidation, and reduction in antioxidant defenses (decreased GSH, GSH/GSSG ratio, and catalase, SOD and GPx activities) and (Na+/K+)-ATPase activity in kidney. Alpha-tocopherol treatment effectively protected kidney from ethanol induced oxidative challenge and improved renal (Na+/K+)-ATPase activity. Ethanol induced oxidative stress in the kidney and decreased (Na+/K+)-ATPase activity could be reversed by treatment with ascorbic acid.

Original languageEnglish
Pages (from-to)608-610
Number of pages3
JournalIndian Journal of Experimental Biology
Volume47
Issue number7
Publication statusPublished - 01-07-2009
Externally publishedYes

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alpha-Tocopherol
Adenosine Triphosphatases
Wistar Rats
Oxidative Stress
Ethanol
Kidney
Glutathione Disulfide
Catalase
Lipid Peroxidation
Ascorbic Acid
Antioxidants
sodium-translocating ATPase

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Biology
  • Cell Biology

Cite this

Mailankot, Maneesh ; Jayalekshmi, H. ; Chakrabarti, Amit ; Alang, Neha ; Vasudevan, D. M. / Effect of alpha-tocopherol supplementation on renal oxidative stress and Na+/K+-adenosine triphosphatase in ethanol treated wistar rats. In: Indian Journal of Experimental Biology. 2009 ; Vol. 47, No. 7. pp. 608-610.
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Effect of alpha-tocopherol supplementation on renal oxidative stress and Na+/K+-adenosine triphosphatase in ethanol treated wistar rats. / Mailankot, Maneesh; Jayalekshmi, H.; Chakrabarti, Amit; Alang, Neha; Vasudevan, D. M.

In: Indian Journal of Experimental Biology, Vol. 47, No. 7, 01.07.2009, p. 608-610.

Research output: Contribution to journalArticle

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