Effect of alpha-tocopherol supplementation on renal oxidative stress and Na+/K+-adenosine triphosphatase in ethanol treated wistar rats

Maneesh Mailankot, H. Jayalekshmi, Amit Chakrabarti, Neha Alang, D. M. Vasudevan

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6 Citations (Scopus)

Abstract

Ethanol intoxication resulted in high extent of lipid peroxidation, and reduction in antioxidant defenses (decreased GSH, GSH/GSSG ratio, and catalase, SOD and GPx activities) and (Na+/K+)-ATPase activity in kidney. Alpha-tocopherol treatment effectively protected kidney from ethanol induced oxidative challenge and improved renal (Na+/K+)-ATPase activity. Ethanol induced oxidative stress in the kidney and decreased (Na+/K+)-ATPase activity could be reversed by treatment with ascorbic acid.

Original languageEnglish
Pages (from-to)608-610
Number of pages3
JournalIndian Journal of Experimental Biology
Volume47
Issue number7
Publication statusPublished - 01-07-2009
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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