Effect of angiotensin converting enzyme inhibitor (captopril) on gastric ulcer production in pylorus ligated rats

S. P. Rao, A. Sathiamoorthy, S. S. Sathiamoorthy

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Intraperitoneal injection of Angiotensin Converting Enzyme inhibitor, captopril, reduced significantly (P < 0.001), the production of gastric ulcers in pylorus-ligated albino rats, compared to the control groups, irrespective of the dose schedule - single or quadruple. In the light of evidence available in the literature, it is reasonable to hypothesise that the anti-ulcer effect of captopril may be mediated through prostaglandins.

Original languageEnglish
Pages (from-to)296-298
Number of pages3
JournalIndian Journal of Physiology and Pharmacology
Issue number3
Publication statusPublished - 01-01-1995
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology

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