Effect of aqueous fruit extract of Emblica officinalis on haloperidol induced catalepsy in albino mice

Sudhakar Pemminati, V. Nair, P. Dorababu, H. N. Gopalakrishna, M. R.S.M. Pai

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Neuroleptic drugs used in the treatment of schizophrenia and other affective disorders are known to produce extrapyramidal side effects. Catalepsy was induced by these drugs in animals and these have been used as models for the extrapyramidal side effects associated with antipsychotic agents in human beings. In the present study, we have attempted to evaluate the protective effect of the aqueous extract of the fruits of Emblica officinalis (EO) on haloperidol (1.0mg/kg intraperitoneal administration) induced catalepsy in mice by employing the standard bar test. Mice were allocated to seven groups, each group containing six animals. The effects of the test drug EO (0.8, 2.0 and 4.0mg/kg doses) and the standard drugs scopolamine (1.0mg/kg) and ondansetron (0.5 and 1.0mg/kg doses) were assessed after single and repeated dose administration for seven days, 30 minutes prior to the haloperidol. Mice were sacrificed on the seventh day and super oxide dismutase (SOD) activity in the brain tissue was estimated by using the Beauchamp and Fridovich method. A significant (P<0.001) reduction in the cataleptic scores was observed in all the test drug treated groups as compared to the control, with maximum reduction in the dose 4.0mg/kg group. Similarly, the maximum reduction in SOD activity (P<0.01) was observed in the dose 4.0mg/kg group. Our study suggests that EO has significantly reduced oxidative stress and the cataleptic score induced by haloperidol. It could be used to prevent drug-induced extrapyramidal side effects.

Original languageEnglish
Pages (from-to)1657-1662
Number of pages6
JournalJournal of Clinical and Diagnostic Research
Volume3
Issue number4
Publication statusPublished - 24-08-2009
Externally publishedYes

Fingerprint

Phyllanthus emblica
Catalepsy
Haloperidol
Fruits
Fruit
Pharmaceutical Preparations
Oxides
Antipsychotic Agents
Animals
Ondansetron
Oxidative stress
Scopolamine Hydrobromide
Mood Disorders
Brain
Schizophrenia
Oxidative Stress
Tissue

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Pemminati, S., Nair, V., Dorababu, P., Gopalakrishna, H. N., & Pai, M. R. S. M. (2009). Effect of aqueous fruit extract of Emblica officinalis on haloperidol induced catalepsy in albino mice. Journal of Clinical and Diagnostic Research, 3(4), 1657-1662.
Pemminati, Sudhakar ; Nair, V. ; Dorababu, P. ; Gopalakrishna, H. N. ; Pai, M. R.S.M. / Effect of aqueous fruit extract of Emblica officinalis on haloperidol induced catalepsy in albino mice. In: Journal of Clinical and Diagnostic Research. 2009 ; Vol. 3, No. 4. pp. 1657-1662.
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Pemminati, S, Nair, V, Dorababu, P, Gopalakrishna, HN & Pai, MRSM 2009, 'Effect of aqueous fruit extract of Emblica officinalis on haloperidol induced catalepsy in albino mice', Journal of Clinical and Diagnostic Research, vol. 3, no. 4, pp. 1657-1662.

Effect of aqueous fruit extract of Emblica officinalis on haloperidol induced catalepsy in albino mice. / Pemminati, Sudhakar; Nair, V.; Dorababu, P.; Gopalakrishna, H. N.; Pai, M. R.S.M.

In: Journal of Clinical and Diagnostic Research, Vol. 3, No. 4, 24.08.2009, p. 1657-1662.

Research output: Contribution to journalArticle

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AU - Pemminati, Sudhakar

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