Effect of ascorbic acid on the monosodium glutamate-induced neurobehavioral changes in periadolescent rats.

Sareesh Naduvil Narayanan, Raju Suresh Kumar, Jaijesh Paval, Satheesha Nayak

Research output: Contribution to journalArticle

Abstract

AIM: In the current study we evaluated adverse effects of monosodium glutamate (MSG) on memory formation and its retrieval as well as the role of ascorbic acid (Vitamin-C) in prevention of MSG-induced alteration of neurobehavioral performance in periadolescent rats. MATERIALS AND METHODS: Healthy male albino Wistar rats (4-6 weeks old), were randomly allotted in four groups. Group I: normal control, who remained in their homecage throughout the experimental period. Group II: vehicle control, who were orally administered with normal saline for three weeks. Group III: MSG, who were orally administered with aqueous solution of MSG (2 mg/g b.w/day), for three weeks. Group IV: MSG+AA, who were administered with aqueous solution of MSG, and subsequently by ascorbic acid (100 mg/kg b.w/day) orally for three weeks. After the experimental period, all animals from all groups were first tested for anxiety followed by passive avoidance behavior. RESULTS: MSG significantly altered the neurobehavioral performance in rats. The alteration manifested as less time spent on the open arm during the EPM test and shorter entrance latency to the dark compartment during the passive avoidance task. All behavioral changes were significantly prevented by simultaneous administration of ascorbic acid with MSG. CONCLUSION: The present data point to the neuroprotective role of ascorbic acid. The ascorbic acid can be used as a therapeutic agent in various cognitive deficits (Fig. 5, Ref. 25). Full Text (Free, PDF) www.bmj.sk.

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalBratislavské lekárske listy
Volume111
Issue number5
Publication statusPublished - 04-08-2010

Fingerprint

Sodium Glutamate
Ascorbic Acid
Avoidance Learning
Wistar Rats
Anxiety

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Narayanan, Sareesh Naduvil ; Kumar, Raju Suresh ; Paval, Jaijesh ; Nayak, Satheesha. / Effect of ascorbic acid on the monosodium glutamate-induced neurobehavioral changes in periadolescent rats. In: Bratislavské lekárske listy. 2010 ; Vol. 111, No. 5. pp. 247-252.
@article{1c7f77040c8c48e2a542d0411246e5a1,
title = "Effect of ascorbic acid on the monosodium glutamate-induced neurobehavioral changes in periadolescent rats.",
abstract = "AIM: In the current study we evaluated adverse effects of monosodium glutamate (MSG) on memory formation and its retrieval as well as the role of ascorbic acid (Vitamin-C) in prevention of MSG-induced alteration of neurobehavioral performance in periadolescent rats. MATERIALS AND METHODS: Healthy male albino Wistar rats (4-6 weeks old), were randomly allotted in four groups. Group I: normal control, who remained in their homecage throughout the experimental period. Group II: vehicle control, who were orally administered with normal saline for three weeks. Group III: MSG, who were orally administered with aqueous solution of MSG (2 mg/g b.w/day), for three weeks. Group IV: MSG+AA, who were administered with aqueous solution of MSG, and subsequently by ascorbic acid (100 mg/kg b.w/day) orally for three weeks. After the experimental period, all animals from all groups were first tested for anxiety followed by passive avoidance behavior. RESULTS: MSG significantly altered the neurobehavioral performance in rats. The alteration manifested as less time spent on the open arm during the EPM test and shorter entrance latency to the dark compartment during the passive avoidance task. All behavioral changes were significantly prevented by simultaneous administration of ascorbic acid with MSG. CONCLUSION: The present data point to the neuroprotective role of ascorbic acid. The ascorbic acid can be used as a therapeutic agent in various cognitive deficits (Fig. 5, Ref. 25). Full Text (Free, PDF) www.bmj.sk.",
author = "Narayanan, {Sareesh Naduvil} and Kumar, {Raju Suresh} and Jaijesh Paval and Satheesha Nayak",
year = "2010",
month = "8",
day = "4",
language = "English",
volume = "111",
pages = "247--252",
journal = "Bratislavske Lekarske Listy",
issn = "0006-9248",
publisher = "Comenius University",
number = "5",

}

Effect of ascorbic acid on the monosodium glutamate-induced neurobehavioral changes in periadolescent rats. / Narayanan, Sareesh Naduvil; Kumar, Raju Suresh; Paval, Jaijesh; Nayak, Satheesha.

In: Bratislavské lekárske listy, Vol. 111, No. 5, 04.08.2010, p. 247-252.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of ascorbic acid on the monosodium glutamate-induced neurobehavioral changes in periadolescent rats.

AU - Narayanan, Sareesh Naduvil

AU - Kumar, Raju Suresh

AU - Paval, Jaijesh

AU - Nayak, Satheesha

PY - 2010/8/4

Y1 - 2010/8/4

N2 - AIM: In the current study we evaluated adverse effects of monosodium glutamate (MSG) on memory formation and its retrieval as well as the role of ascorbic acid (Vitamin-C) in prevention of MSG-induced alteration of neurobehavioral performance in periadolescent rats. MATERIALS AND METHODS: Healthy male albino Wistar rats (4-6 weeks old), were randomly allotted in four groups. Group I: normal control, who remained in their homecage throughout the experimental period. Group II: vehicle control, who were orally administered with normal saline for three weeks. Group III: MSG, who were orally administered with aqueous solution of MSG (2 mg/g b.w/day), for three weeks. Group IV: MSG+AA, who were administered with aqueous solution of MSG, and subsequently by ascorbic acid (100 mg/kg b.w/day) orally for three weeks. After the experimental period, all animals from all groups were first tested for anxiety followed by passive avoidance behavior. RESULTS: MSG significantly altered the neurobehavioral performance in rats. The alteration manifested as less time spent on the open arm during the EPM test and shorter entrance latency to the dark compartment during the passive avoidance task. All behavioral changes were significantly prevented by simultaneous administration of ascorbic acid with MSG. CONCLUSION: The present data point to the neuroprotective role of ascorbic acid. The ascorbic acid can be used as a therapeutic agent in various cognitive deficits (Fig. 5, Ref. 25). Full Text (Free, PDF) www.bmj.sk.

AB - AIM: In the current study we evaluated adverse effects of monosodium glutamate (MSG) on memory formation and its retrieval as well as the role of ascorbic acid (Vitamin-C) in prevention of MSG-induced alteration of neurobehavioral performance in periadolescent rats. MATERIALS AND METHODS: Healthy male albino Wistar rats (4-6 weeks old), were randomly allotted in four groups. Group I: normal control, who remained in their homecage throughout the experimental period. Group II: vehicle control, who were orally administered with normal saline for three weeks. Group III: MSG, who were orally administered with aqueous solution of MSG (2 mg/g b.w/day), for three weeks. Group IV: MSG+AA, who were administered with aqueous solution of MSG, and subsequently by ascorbic acid (100 mg/kg b.w/day) orally for three weeks. After the experimental period, all animals from all groups were first tested for anxiety followed by passive avoidance behavior. RESULTS: MSG significantly altered the neurobehavioral performance in rats. The alteration manifested as less time spent on the open arm during the EPM test and shorter entrance latency to the dark compartment during the passive avoidance task. All behavioral changes were significantly prevented by simultaneous administration of ascorbic acid with MSG. CONCLUSION: The present data point to the neuroprotective role of ascorbic acid. The ascorbic acid can be used as a therapeutic agent in various cognitive deficits (Fig. 5, Ref. 25). Full Text (Free, PDF) www.bmj.sk.

UR - http://www.scopus.com/inward/record.url?scp=77955084530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955084530&partnerID=8YFLogxK

M3 - Article

VL - 111

SP - 247

EP - 252

JO - Bratislavske Lekarske Listy

JF - Bratislavske Lekarske Listy

SN - 0006-9248

IS - 5

ER -