Effect of atorvastatin on advanced oxidation protein products and malondialdehyde in dyslipidemic patients with and without diabetes

Benedicta D'Souza, Michele P. Christian, Raviraja, Ashok Prabhu, Beena V. Shetty, Vivian D'Souza

Research output: Contribution to journalArticle

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Abstract

The aim of this study was to ascertain the effect of atorvastatin on oxidative stress parameters in dyslipidemic patients with or without diabetes. Advanced oxidation of protein products(AOPP), was measured as a marker for protein oxidation, malondialdehyde was studied as a marker of lipid peroxidation and glutathione (G-SH) was estimated to study the antioxidant potential of these patients. The results were compared with normal healthy control subjects. This study suggests that there is a significant increase in both AOPP and MDA in dyslipidemic, diabetic patients with or without atorvastatin. There is no significant change in antioxidant G-SH levels in these patients, compared to the control subjects. This study indicates that atorvastatin increases the oxidative stress.

Original languageEnglish
JournalInternational Journal of Pharma and Bio Sciences
Volume4
Issue number4
Publication statusPublished - 01-10-2013

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Advanced Oxidation Protein Products
Medical problems
Malondialdehyde
Oxidative stress
Antioxidants
Oxidative Stress
Glutathione
Lipid Peroxidation
Lipids
Oxidation
Healthy Volunteers
Atorvastatin Calcium
Proteins

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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abstract = "The aim of this study was to ascertain the effect of atorvastatin on oxidative stress parameters in dyslipidemic patients with or without diabetes. Advanced oxidation of protein products(AOPP), was measured as a marker for protein oxidation, malondialdehyde was studied as a marker of lipid peroxidation and glutathione (G-SH) was estimated to study the antioxidant potential of these patients. The results were compared with normal healthy control subjects. This study suggests that there is a significant increase in both AOPP and MDA in dyslipidemic, diabetic patients with or without atorvastatin. There is no significant change in antioxidant G-SH levels in these patients, compared to the control subjects. This study indicates that atorvastatin increases the oxidative stress.",
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Effect of atorvastatin on advanced oxidation protein products and malondialdehyde in dyslipidemic patients with and without diabetes. / D'Souza, Benedicta; Christian, Michele P.; Raviraja; Prabhu, Ashok; Shetty, Beena V.; D'Souza, Vivian.

In: International Journal of Pharma and Bio Sciences, Vol. 4, No. 4, 01.10.2013.

Research output: Contribution to journalArticle

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AU - D'Souza, Benedicta

AU - Christian, Michele P.

AU - Raviraja,

AU - Prabhu, Ashok

AU - Shetty, Beena V.

AU - D'Souza, Vivian

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