Effect of Atorvastatin on Serum Para-Oxonase-1 and C-Reactive Protein in Wistar Rats

Aradhana Marathe, B. Ganaraja, K. Ashwin Shenoy, K. Ashok Prabhu, M. Nandini

Research output: Contribution to journalArticle

Abstract

Statins have been widely used in the treatment of hypercholesterolemia and atherosclerotic disease. Atherosclerosis is an ongoing inflammatory response which is involved in mediating all stages of this multifactorial disease. The present study focuses on the long term effect of atorvastatin on the anti-atherogenic and anti-inflammatory properties with reference to para-oxonase and C-reactive protein levels in rats. Thirty six Wistar albino rats obtained from the central animal house were divided into 6 groups with 6 rats in each group. Group I and IV served as the control for male and female rats respectively. Group II and V comprised of male and female rats that received low dose of atorvastatin (10 mg/kg body weight). Group III and VI comprised of male and female rats that received high dose of atorvastatin (40 mg/kg body weight) for period of 45 days. Blood was collected by cardiac puncture. The plasma was analysed for total cholesterol, HDL cholesterol, C-reactive protein (CRP) and Paraoxonase-1, both basal Paraoxonase (BPON) & Salt stimulated Paraoxonase (SPON) by standard procedures. Results of the present study showed a reduction in TC and increase in HDL-C in both groups of rats receiving low and high dose of Atorvastatin. Both male and female rats responded similarly. The levels of CRP decreased in the male rats receiving either low or high dose of atorvastatin. Activity of SPON and BPON was increased only in the group receiving high dose of atorvastatin in both male and female rats.

Original languageEnglish
Pages (from-to)312-317
Number of pages6
JournalIndian Journal of Clinical Biochemistry
Volume34
Issue number3
DOIs
Publication statusPublished - 01-07-2019

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C-Reactive Protein
Wistar Rats
Rats
Aryldialkylphosphatase
Serum
Body Weight
Atorvastatin Calcium
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypercholesterolemia
Cholesterol
Punctures
HDL Cholesterol
Atherosclerosis
Anti-Inflammatory Agents
Salts
Animals
Blood
Plasmas

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Marathe, Aradhana ; Ganaraja, B. ; Ashwin Shenoy, K. ; Ashok Prabhu, K. ; Nandini, M. / Effect of Atorvastatin on Serum Para-Oxonase-1 and C-Reactive Protein in Wistar Rats. In: Indian Journal of Clinical Biochemistry. 2019 ; Vol. 34, No. 3. pp. 312-317.
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Effect of Atorvastatin on Serum Para-Oxonase-1 and C-Reactive Protein in Wistar Rats. / Marathe, Aradhana; Ganaraja, B.; Ashwin Shenoy, K.; Ashok Prabhu, K.; Nandini, M.

In: Indian Journal of Clinical Biochemistry, Vol. 34, No. 3, 01.07.2019, p. 312-317.

Research output: Contribution to journalArticle

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T1 - Effect of Atorvastatin on Serum Para-Oxonase-1 and C-Reactive Protein in Wistar Rats

AU - Marathe, Aradhana

AU - Ganaraja, B.

AU - Ashwin Shenoy, K.

AU - Ashok Prabhu, K.

AU - Nandini, M.

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AB - Statins have been widely used in the treatment of hypercholesterolemia and atherosclerotic disease. Atherosclerosis is an ongoing inflammatory response which is involved in mediating all stages of this multifactorial disease. The present study focuses on the long term effect of atorvastatin on the anti-atherogenic and anti-inflammatory properties with reference to para-oxonase and C-reactive protein levels in rats. Thirty six Wistar albino rats obtained from the central animal house were divided into 6 groups with 6 rats in each group. Group I and IV served as the control for male and female rats respectively. Group II and V comprised of male and female rats that received low dose of atorvastatin (10 mg/kg body weight). Group III and VI comprised of male and female rats that received high dose of atorvastatin (40 mg/kg body weight) for period of 45 days. Blood was collected by cardiac puncture. The plasma was analysed for total cholesterol, HDL cholesterol, C-reactive protein (CRP) and Paraoxonase-1, both basal Paraoxonase (BPON) & Salt stimulated Paraoxonase (SPON) by standard procedures. Results of the present study showed a reduction in TC and increase in HDL-C in both groups of rats receiving low and high dose of Atorvastatin. Both male and female rats responded similarly. The levels of CRP decreased in the male rats receiving either low or high dose of atorvastatin. Activity of SPON and BPON was increased only in the group receiving high dose of atorvastatin in both male and female rats.

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