Effect of azidothymidine on the radiation-induced LDH release in HeLa cells

G. C. Jagetia, R. Aruna, B. S. Nayak

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Abstract

Treatment of HeLa cells with various concentrations of 0, 0.01, 0.1, 1, 10, and 100 μM AZT resulted in a concentration dependent elevation in the LDH release at 0, 0.5, 1, 2 and 4 h post-treatment. An elevation of 1.7 to 9.2 fold in LDH content was observed at 1 h post-treatment depending on the drug concentration. Similarly, treatment of HeLa cells with 0.1 μM AZT before irradiation caused an irradiation dose dependent increase in the LDH release in AZT + irradiation groups. This increase in LDH release was approximately two fold greater at 0 h post-irradiation in AZT + irradiation group, when compared with the PBS + irradiation group. This trend of elevation in LDH release continued up to 2 h, except 2 and 3 Gy, where it was 1.7 fold in the former group when compared with the latter. However, a peak level of LDH release was observed at 0 h post-irradiation.

Original languageEnglish
Pages (from-to)837-840
Number of pages4
JournalPharmazie
Volume55
Issue number11
Publication statusPublished - 05-12-2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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    Jagetia, G. C., Aruna, R., & Nayak, B. S. (2000). Effect of azidothymidine on the radiation-induced LDH release in HeLa cells. Pharmazie, 55(11), 837-840.