Effect of Berberis aristata on type I and II diabetes mellitus models in albino rats

Naresh Kumar Rameshwar, Rekha Raghuveer Shenoy, Arun Theerthahalli Sudheendra, Chamalamudi Mallikarjuna Rao

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: To explore the anti-diabetic potential of Berberis aristata in rodents. Materials and methods: Albino rats of Wistar strain were treated with the aqueous and ethanolic extracts of BA. Blood glucose level, liver glycogen level, thio- barbituric acid reactive substance (TBARS) and protein in pancreas were estimated. Results: Both the extracts of BA produced significant hypoglycemic effect in Streptozotocin (type I) and Streptozotocin- Nicotinamide (type II) induced diabetic models. Significant (p< 0.05) reversal in liver glycogen depletion was observed. The oxidative stress caused by streptozotocin-induced diabetes was not significantly altered by the extracts. The extracts showed more hypoglycemic effect than glibenclamide in the Streptozotocin (STZ) - Nicotinamide induced diabetic model. Conclusion: Berberis aristata can be a promising candidate for the treatment of type II diabetes mellitus.

Original languageEnglish
Pages (from-to)89-96
Number of pages8
JournalPharmacologyonline
Volume1
Publication statusPublished - 2009

Fingerprint

Berberis
Streptozocin
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Liver Glycogen
Niacinamide
Hypoglycemic Agents
Experimental Diabetes Mellitus
Glyburide
Blood Glucose
Wistar Rats
Pancreas
Rodentia
Oxidative Stress
Proteins

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

@article{f06a1db2296f40c9a69beabaa4276ae3,
title = "Effect of Berberis aristata on type I and II diabetes mellitus models in albino rats",
abstract = "Aim: To explore the anti-diabetic potential of Berberis aristata in rodents. Materials and methods: Albino rats of Wistar strain were treated with the aqueous and ethanolic extracts of BA. Blood glucose level, liver glycogen level, thio- barbituric acid reactive substance (TBARS) and protein in pancreas were estimated. Results: Both the extracts of BA produced significant hypoglycemic effect in Streptozotocin (type I) and Streptozotocin- Nicotinamide (type II) induced diabetic models. Significant (p< 0.05) reversal in liver glycogen depletion was observed. The oxidative stress caused by streptozotocin-induced diabetes was not significantly altered by the extracts. The extracts showed more hypoglycemic effect than glibenclamide in the Streptozotocin (STZ) - Nicotinamide induced diabetic model. Conclusion: Berberis aristata can be a promising candidate for the treatment of type II diabetes mellitus.",
author = "Rameshwar, {Naresh Kumar} and Shenoy, {Rekha Raghuveer} and Sudheendra, {Arun Theerthahalli} and Rao, {Chamalamudi Mallikarjuna}",
year = "2009",
language = "English",
volume = "1",
pages = "89--96",
journal = "Pharmacologyonline",
issn = "1827-8620",
publisher = "SILAE (Italo-Latin American Society of Ethnomedicine)",

}

Effect of Berberis aristata on type I and II diabetes mellitus models in albino rats. / Rameshwar, Naresh Kumar; Shenoy, Rekha Raghuveer; Sudheendra, Arun Theerthahalli; Rao, Chamalamudi Mallikarjuna.

In: Pharmacologyonline, Vol. 1, 2009, p. 89-96.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of Berberis aristata on type I and II diabetes mellitus models in albino rats

AU - Rameshwar, Naresh Kumar

AU - Shenoy, Rekha Raghuveer

AU - Sudheendra, Arun Theerthahalli

AU - Rao, Chamalamudi Mallikarjuna

PY - 2009

Y1 - 2009

N2 - Aim: To explore the anti-diabetic potential of Berberis aristata in rodents. Materials and methods: Albino rats of Wistar strain were treated with the aqueous and ethanolic extracts of BA. Blood glucose level, liver glycogen level, thio- barbituric acid reactive substance (TBARS) and protein in pancreas were estimated. Results: Both the extracts of BA produced significant hypoglycemic effect in Streptozotocin (type I) and Streptozotocin- Nicotinamide (type II) induced diabetic models. Significant (p< 0.05) reversal in liver glycogen depletion was observed. The oxidative stress caused by streptozotocin-induced diabetes was not significantly altered by the extracts. The extracts showed more hypoglycemic effect than glibenclamide in the Streptozotocin (STZ) - Nicotinamide induced diabetic model. Conclusion: Berberis aristata can be a promising candidate for the treatment of type II diabetes mellitus.

AB - Aim: To explore the anti-diabetic potential of Berberis aristata in rodents. Materials and methods: Albino rats of Wistar strain were treated with the aqueous and ethanolic extracts of BA. Blood glucose level, liver glycogen level, thio- barbituric acid reactive substance (TBARS) and protein in pancreas were estimated. Results: Both the extracts of BA produced significant hypoglycemic effect in Streptozotocin (type I) and Streptozotocin- Nicotinamide (type II) induced diabetic models. Significant (p< 0.05) reversal in liver glycogen depletion was observed. The oxidative stress caused by streptozotocin-induced diabetes was not significantly altered by the extracts. The extracts showed more hypoglycemic effect than glibenclamide in the Streptozotocin (STZ) - Nicotinamide induced diabetic model. Conclusion: Berberis aristata can be a promising candidate for the treatment of type II diabetes mellitus.

UR - http://www.scopus.com/inward/record.url?scp=65449128066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65449128066&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:65449128066

VL - 1

SP - 89

EP - 96

JO - Pharmacologyonline

JF - Pharmacologyonline

SN - 1827-8620

ER -