Aim: To explore the anti-diabetic potential of Berberis aristata in rodents. Materials and methods: Albino rats of Wistar strain were treated with the aqueous and ethanolic extracts of BA. Blood glucose level, liver glycogen level, thio- barbituric acid reactive substance (TBARS) and protein in pancreas were estimated. Results: Both the extracts of BA produced significant hypoglycemic effect in Streptozotocin (type I) and Streptozotocin- Nicotinamide (type II) induced diabetic models. Significant (p< 0.05) reversal in liver glycogen depletion was observed. The oxidative stress caused by streptozotocin-induced diabetes was not significantly altered by the extracts. The extracts showed more hypoglycemic effect than glibenclamide in the Streptozotocin (STZ) - Nicotinamide induced diabetic model. Conclusion: Berberis aristata can be a promising candidate for the treatment of type II diabetes mellitus.
|Number of pages||8|
|Publication status||Published - 2009|
All Science Journal Classification (ASJC) codes
- Drug Discovery