Effect of Cassia auriculata Linn. Root extract on cisplatin and gentamicin-induced renal injury

S. Annie, P.L. Rajagopal, S. Malini

Research output: Contribution to journalArticle

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Abstract

The ethanol extract of the roots of Cassia auriculata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced renal injury in male albino rats. In the cisplatin model, the extract at doses of 300 and 600 mg/kg body wt. reduced elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen. In the gentamicin model, the ethanol extract at a dose of 600 mg/kg body wt. reduced blood urea and serum creatinine effectively in both the curative and the preventive regimen. The extract had a marked nitric oxide free-radical-scavenging effect. The findings suggest that the probable mechanism of nephroprotection by C. auriculata against cisplatin- and gentamicin-induced renal injury could be due to its antioxidant and free-radical-scavenging property. © 2005 Elsevier GmbH. All rights reserved.
Original languageEnglish
Pages (from-to)555-560
Number of pages6
JournalPhytomedicine
Volume12
Issue number8
DOIs
Publication statusPublished - 2005

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Cassia
Gentamicins
Cisplatin
Kidney
Free Radicals
Urea
Creatinine
Wounds and Injuries
Ethanol
Serum
Nitric Oxide
Antioxidants

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Annie, S. ; Rajagopal, P.L. ; Malini, S. / Effect of Cassia auriculata Linn. Root extract on cisplatin and gentamicin-induced renal injury. In: Phytomedicine. 2005 ; Vol. 12, No. 8. pp. 555-560.
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title = "Effect of Cassia auriculata Linn. Root extract on cisplatin and gentamicin-induced renal injury",
abstract = "The ethanol extract of the roots of Cassia auriculata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced renal injury in male albino rats. In the cisplatin model, the extract at doses of 300 and 600 mg/kg body wt. reduced elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen. In the gentamicin model, the ethanol extract at a dose of 600 mg/kg body wt. reduced blood urea and serum creatinine effectively in both the curative and the preventive regimen. The extract had a marked nitric oxide free-radical-scavenging effect. The findings suggest that the probable mechanism of nephroprotection by C. auriculata against cisplatin- and gentamicin-induced renal injury could be due to its antioxidant and free-radical-scavenging property. {\circledC} 2005 Elsevier GmbH. All rights reserved.",
author = "S. Annie and P.L. Rajagopal and S. Malini",
note = "Cited By :65 Export Date: 10 November 2017 CODEN: PYTOE Correspondence Address: Annie, S.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal, India; email: annie.shirwaikar@cops.manipal.edu Chemicals/CAS: alcohol, 64-17-5; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; creatinine, 19230-81-0, 60-27-5; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; nitric oxide, 10102-43-9; urea, 57-13-6; Cisplatin, 15663-27-1; Creatinine, 60-27-5; Free Radical Scavengers; Gentamicins; Plant Extracts; Protective Agents; Urea, 57-13-6 References: Akira, H., Toshiaki, N., Masahioo, Y., Role of vasoactive substances in gentamicin induced acute renal failure (1994) Asian Nephrology, Vol. 395, , K.S. Chugh Oxford University Press New Delhi; Barry, M.B., (2000) Toxic Nephropathies. The Kidney, 2, pp. 3-67. , W.B Saunders Company, Philadelphia; Devipriya, S., Shyamaladevim, C.S., Protective effect of quercetin in cisplatin induced cell injury in the rat kidney (1999) Indian J. Pharmacol., 31, p. 422; Greggi Antunes, L.M., Darin, J.D., Bianchi, M., Protective effects of Vit C against cisplatin induced nephrotoxicity and lipid peroxidation in adult rats. a dose dependent study (2000) Pharmacol. Res., 41, pp. 405-411; Harborne, J.B., (1984) Phytochemical Methods, Vol. 123, , Chapman & Hall London; Kokate, C.K., (1994) Practical Pharmacognosy, Vols. 107-111, , Vallabh Prakashan New Delhi; Lindquist, S., The heat shock response (1986) Ann. Rev. Biochem., 55, p. 1151; Rai, K.N., Dasundhi, R.A., A new flavone glycoside from the roots of Cassia auriculata (1990) J. Bangladesh Acad. Sci., 14 (1), pp. 57-61; Rao, M., Rao, M.N.A., Protective effect of selenomethionine against cisplatin induced renal toxicity in mice and rats (1998) J. Pharm. Pharmacol., 50, p. 687; Rao, G.N., Kumar, P.M., Dhendapani, V.S., Ramakrishna, T., Constituents of C. auriculata (2000) Fitoterapia, 71 (1), pp. 82-83; Varley, H., Alan, H.G., (1984) Tests in Renal Disease. In: Practical Clinical Biochemistry, Vol. 1123, , William Heinemann Medical Book Ltd. London; Vedavathi, S., Mrudula, V., Sudhakar, A., (1997) Tribal Medicine of Chittoor District, AndhraPradesh, India, Vols. 48-49, , Herbal Folklore Research Center Tirupati",
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Effect of Cassia auriculata Linn. Root extract on cisplatin and gentamicin-induced renal injury. / Annie, S.; Rajagopal, P.L.; Malini, S.

In: Phytomedicine, Vol. 12, No. 8, 2005, p. 555-560.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of Cassia auriculata Linn. Root extract on cisplatin and gentamicin-induced renal injury

AU - Annie, S.

AU - Rajagopal, P.L.

AU - Malini, S.

N1 - Cited By :65 Export Date: 10 November 2017 CODEN: PYTOE Correspondence Address: Annie, S.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal, India; email: annie.shirwaikar@cops.manipal.edu Chemicals/CAS: alcohol, 64-17-5; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; creatinine, 19230-81-0, 60-27-5; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; nitric oxide, 10102-43-9; urea, 57-13-6; Cisplatin, 15663-27-1; Creatinine, 60-27-5; Free Radical Scavengers; Gentamicins; Plant Extracts; Protective Agents; Urea, 57-13-6 References: Akira, H., Toshiaki, N., Masahioo, Y., Role of vasoactive substances in gentamicin induced acute renal failure (1994) Asian Nephrology, Vol. 395, , K.S. Chugh Oxford University Press New Delhi; Barry, M.B., (2000) Toxic Nephropathies. The Kidney, 2, pp. 3-67. , W.B Saunders Company, Philadelphia; Devipriya, S., Shyamaladevim, C.S., Protective effect of quercetin in cisplatin induced cell injury in the rat kidney (1999) Indian J. Pharmacol., 31, p. 422; Greggi Antunes, L.M., Darin, J.D., Bianchi, M., Protective effects of Vit C against cisplatin induced nephrotoxicity and lipid peroxidation in adult rats. a dose dependent study (2000) Pharmacol. Res., 41, pp. 405-411; Harborne, J.B., (1984) Phytochemical Methods, Vol. 123, , Chapman & Hall London; Kokate, C.K., (1994) Practical Pharmacognosy, Vols. 107-111, , Vallabh Prakashan New Delhi; Lindquist, S., The heat shock response (1986) Ann. Rev. Biochem., 55, p. 1151; Rai, K.N., Dasundhi, R.A., A new flavone glycoside from the roots of Cassia auriculata (1990) J. Bangladesh Acad. Sci., 14 (1), pp. 57-61; Rao, M., Rao, M.N.A., Protective effect of selenomethionine against cisplatin induced renal toxicity in mice and rats (1998) J. Pharm. Pharmacol., 50, p. 687; Rao, G.N., Kumar, P.M., Dhendapani, V.S., Ramakrishna, T., Constituents of C. auriculata (2000) Fitoterapia, 71 (1), pp. 82-83; Varley, H., Alan, H.G., (1984) Tests in Renal Disease. In: Practical Clinical Biochemistry, Vol. 1123, , William Heinemann Medical Book Ltd. London; Vedavathi, S., Mrudula, V., Sudhakar, A., (1997) Tribal Medicine of Chittoor District, AndhraPradesh, India, Vols. 48-49, , Herbal Folklore Research Center Tirupati

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AB - The ethanol extract of the roots of Cassia auriculata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced renal injury in male albino rats. In the cisplatin model, the extract at doses of 300 and 600 mg/kg body wt. reduced elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen. In the gentamicin model, the ethanol extract at a dose of 600 mg/kg body wt. reduced blood urea and serum creatinine effectively in both the curative and the preventive regimen. The extract had a marked nitric oxide free-radical-scavenging effect. The findings suggest that the probable mechanism of nephroprotection by C. auriculata against cisplatin- and gentamicin-induced renal injury could be due to its antioxidant and free-radical-scavenging property. © 2005 Elsevier GmbH. All rights reserved.

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