The ethanol extract of the roots of Cassia auriculata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced renal injury in male albino rats. In the cisplatin model, the extract at doses of 300 and 600 mg/kg body wt. reduced elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen. In the gentamicin model, the ethanol extract at a dose of 600 mg/kg body wt. reduced blood urea and serum creatinine effectively in both the curative and the preventive regimen. The extract had a marked nitric oxide free-radical-scavenging effect. The findings suggest that the probable mechanism of nephroprotection by C. auriculata against cisplatin- and gentamicin-induced renal injury could be due to its antioxidant and free-radical-scavenging property. © 2005 Elsevier GmbH. All rights reserved.
Annie, S., Rajagopal, P. L., & Malini, S. (2005). Effect of Cassia auriculata Linn. Root extract on cisplatin and gentamicin-induced renal injury. Phytomedicine, 12(8), 555-560. https://doi.org/10.1016/j.phymed.2003.11.010