Effect of Cassia auriculata Linn. Root extract on cisplatin and gentamicin-induced renal injury

S. Annie, P.L. Rajagopal, S. Malini

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Abstract

The ethanol extract of the roots of Cassia auriculata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced renal injury in male albino rats. In the cisplatin model, the extract at doses of 300 and 600 mg/kg body wt. reduced elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen. In the gentamicin model, the ethanol extract at a dose of 600 mg/kg body wt. reduced blood urea and serum creatinine effectively in both the curative and the preventive regimen. The extract had a marked nitric oxide free-radical-scavenging effect. The findings suggest that the probable mechanism of nephroprotection by C. auriculata against cisplatin- and gentamicin-induced renal injury could be due to its antioxidant and free-radical-scavenging property. © 2005 Elsevier GmbH. All rights reserved.
Original languageEnglish
Pages (from-to)555-560
Number of pages6
JournalPhytomedicine
Volume12
Issue number8
DOIs
Publication statusPublished - 2005

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